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BANP BTG3 associated nuclear protein [ Homo sapiens (human) ]

Gene ID: 54971, updated on 12-May-2019

Summary

Official Symbol
BANPprovided by HGNC
Official Full Name
BTG3 associated nuclear proteinprovided by HGNC
Primary source
HGNC:HGNC:13450
See related
Ensembl:ENSG00000172530 MIM:611564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BEND1; SMAR1; SMARBP1
Summary
This gene encodes a protein that binds to matrix attachment regions. The protein forms a complex with p53 and negatively regulates p53 transcription, and functions as a tumor suppressor and cell cycle regulator. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
Expression
Ubiquitous expression in testis (RPKM 1.3), spleen (RPKM 1.1) and 25 other tissues See more
Orthologs

Genomic context

See BANP in Genome Data Viewer
Location:
16q24.2
Exon count:
28
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (87949216..88077318)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (87984231..88110924)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene carbonic anhydrase 5A Neighboring gene small EDRK-rich factor 1 pseudogene Neighboring gene uncharacterized LOC105369246 Neighboring gene uncharacterized LOC400553

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
NHGRI GWA Catalog
Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
NHGRI GWA Catalog
New loci associated with central cornea thickness include COL5A1, AKAP13 and AVGR8.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat SMAR1 recruits HDAC1-Sin3 corepressor complex to remodel chromatin structure at HIV-1 LTR. Overexpression of SMAR1 leads to reduction in LTR-mediated transcription in a Tat dependent and independent manner, resulting in a decreased virion production PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Association with Co-factors, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Association with Co-factors, organism-specific biosystemAssociation of TP53 (p53) with various transcriptional co-factors can promote, inhibit or provide specificity towards either transcription of cell cycle arrest genes or transcription of cell death ge...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10177, FLJ20538, DKFZp761H172

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
chromatin organization IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
protein localization to nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein BANP
Names
BEN domain-containing protein 1
scaffold/matrix-associated region-1-binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029918.1 RefSeqGene

    Range
    5001..130887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001173539.1NP_001167010.1  protein BANP isoform c

    See identical proteins and their annotated locations for NP_001167010.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and 5' UTR, uses one alternate in-frame splices site, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (c) differs at two internal regions, compared to isoform g.
    Source sequence(s)
    AK001039, AK125232, AK293472, AL157429
    UniProtKB/Swiss-Prot
    Q8N9N5
    UniProtKB/TrEMBL
    B3KM38, B4DE54, Q9NSS6
    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  2. NM_001173540.1NP_001167011.1  protein BANP isoform d

    See identical proteins and their annotated locations for NP_001167011.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and 5' UTR, uses three alternate in-frame splices sites, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (d) differs at four internal regions, compared to isoform g.
    Source sequence(s)
    AK001039, AK125232, AK297945, AL157429
    Consensus CDS
    CCDS54055.1
    UniProtKB/Swiss-Prot
    Q8N9N5
    UniProtKB/TrEMBL
    B3KM38, Q9NSS6
    Related
    ENSP00000487304.1, ENST00000626016.2
    Conserved Domains (1) summary
    smart01025
    Location:224297
    BEN; The BEN domain is found in diverse animal proteins
  3. NM_001173541.1NP_001167012.1  protein BANP isoform e

    See identical proteins and their annotated locations for NP_001167012.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and 5' UTR, uses one alternate in-frame splices site, and lacks two alternate in-frame exons in the coding region, compared to variant 7. The resulting isoform (e) differs at three internal regions, compared to isoform g.
    Source sequence(s)
    AK001039, AK297945, AK315089, AL157429
    Consensus CDS
    CCDS54053.1
    UniProtKB/Swiss-Prot
    Q8N9N5
    UniProtKB/TrEMBL
    B3KM38, Q9NSS6
    Related
    ENSP00000432508.1, ENST00000479780.6
    Conserved Domains (1) summary
    smart01025
    Location:218291
    BEN; The BEN domain is found in diverse animal proteins
  4. NM_001173542.1NP_001167013.1  protein BANP isoform f

    See identical proteins and their annotated locations for NP_001167013.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and 5' UTR, uses two alternate in-frame splices site, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (f) differs at three internal regions, compared to isoform g.
    Source sequence(s)
    AK293472, AK297945, AK315535, AL157429
    Consensus CDS
    CCDS54052.1
    UniProtKB/Swiss-Prot
    Q8N9N5
    UniProtKB/TrEMBL
    A0A0S2Z5M2, B4DE54, Q9NSS6
    Related
    ENSP00000444352.1, ENST00000538234.5
    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  5. NM_001173543.1NP_001167014.1  protein BANP isoform g

    See identical proteins and their annotated locations for NP_001167014.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents the longest transcript and encodes the longest isoform (g).
    Source sequence(s)
    AC127455, AK001039, AK094158, AK125232, AL157429
    Consensus CDS
    CCDS54054.1
    UniProtKB/Swiss-Prot
    Q8N9N5
    UniProtKB/TrEMBL
    B3KM38, Q9NSS6
    Related
    ENSP00000376902.1, ENST00000393207.5
    Conserved Domains (1) summary
    smart01025
    Location:249322
    BEN; The BEN domain is found in diverse animal proteins
  6. NM_017869.3NP_060339.2  protein BANP isoform a

    See identical proteins and their annotated locations for NP_060339.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, uses two alternate in-frame splices sites, and lacks two alternate in-frame exons in the coding region, compared to variant 7. The resulting isoform (a) differs at four internal regions, compared to isoform g.
    Source sequence(s)
    AK000545, AK001039, AL157429, BC009424, CN289917, DA632793, T49823
    Consensus CDS
    CCDS42215.1
    UniProtKB/Swiss-Prot
    Q8N9N5
    UniProtKB/TrEMBL
    A0A0S2Z5C2, B3KM38, Q9NSS6
    Related
    ENSP00000347125.4, ENST00000355022.8
    Conserved Domains (1) summary
    smart01025
    Location:218291
    BEN; The BEN domain is found in diverse animal proteins
  7. NM_079837.2NP_524576.2  protein BANP isoform b

    See identical proteins and their annotated locations for NP_524576.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, uses two alternate in-frame splices sites, and lacks one alternate in-frame exon in the coding region, compared to variant 7. The resulting isoform (b) differs at three internal regions, compared to isoform g.
    Source sequence(s)
    AK001039, AK125232, AL157429, CN289917, DA632793
    Consensus CDS
    CCDS10966.2
    UniProtKB/Swiss-Prot
    Q8N9N5
    UniProtKB/TrEMBL
    B3KM38, Q9NSS6
    Related
    ENSP00000376903.2, ENST00000393208.6
    Conserved Domains (1) summary
    smart01025
    Location:218291
    BEN; The BEN domain is found in diverse animal proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    87949216..88077318
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523176.2XP_011521478.1  protein BANP isoform X1

    See identical proteins and their annotated locations for XP_011521478.1

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  2. XM_017023379.2XP_016878868.1  protein BANP isoform X4

    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  3. XM_011523175.3XP_011521477.1  protein BANP isoform X1

    See identical proteins and their annotated locations for XP_011521477.1

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  4. XM_024450331.1XP_024306099.1  protein BANP isoform X19

    Conserved Domains (1) summary
    smart01025
    Location:2396
    BEN; The BEN domain is found in diverse animal proteins
  5. XM_024450334.1XP_024306102.1  protein BANP isoform X20

    Conserved Domains (1) summary
    smart01025
    Location:2396
    BEN; The BEN domain is found in diverse animal proteins
  6. XM_011523172.2XP_011521474.1  protein BANP isoform X1

    See identical proteins and their annotated locations for XP_011521474.1

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  7. XM_024450323.1XP_024306091.1  protein BANP isoform X7

    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  8. XM_024450322.1XP_024306090.1  protein BANP isoform X4

    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  9. XM_024450324.1XP_024306092.1  protein BANP isoform X8

    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  10. XM_024450326.1XP_024306094.1  protein BANP isoform X12

    Conserved Domains (1) summary
    smart01025
    Location:218291
    BEN; The BEN domain is found in diverse animal proteins
  11. XM_017023378.1XP_016878867.1  protein BANP isoform X1

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  12. XM_024450328.1XP_024306096.1  protein BANP isoform X15

    Conserved Domains (1) summary
    smart01025
    Location:142215
    BEN; The BEN domain is found in diverse animal proteins
  13. XM_024450332.1XP_024306100.1  protein BANP isoform X19

    Conserved Domains (1) summary
    smart01025
    Location:2396
    BEN; The BEN domain is found in diverse animal proteins
  14. XM_024450327.1XP_024306095.1  protein BANP isoform X14

    Conserved Domains (1) summary
    smart01025
    Location:154227
    BEN; The BEN domain is found in diverse animal proteins
  15. XM_017023381.1XP_016878870.1  protein BANP isoform X11

  16. XM_011523179.3XP_011521481.1  protein BANP isoform X3

    See identical proteins and their annotated locations for XP_011521481.1

    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  17. XM_005256009.4XP_005256066.1  protein BANP isoform X7

    See identical proteins and their annotated locations for XP_005256066.1

    UniProtKB/TrEMBL
    A0A0S2Z5M2
    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  18. XM_024450320.1XP_024306088.1  protein BANP isoform X4

    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  19. XM_011523170.2XP_011521472.1  protein BANP isoform X1

    See identical proteins and their annotated locations for XP_011521472.1

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  20. XM_005256008.3XP_005256065.1  protein BANP isoform X5

    See identical proteins and their annotated locations for XP_005256065.1

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  21. XM_011523178.2XP_011521480.1  protein BANP isoform X2

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  22. XM_011523181.2XP_011521483.1  protein BANP isoform X6

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  23. XM_017023380.2XP_016878869.1  protein BANP isoform X9

    UniProtKB/TrEMBL
    A0A0S2Z5G4
    Conserved Domains (1) summary
    smart01025
    Location:218291
    BEN; The BEN domain is found in diverse animal proteins
  24. XM_011523182.1XP_011521484.1  protein BANP isoform X13

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  25. XM_011523180.2XP_011521482.1  protein BANP isoform X3

    See identical proteins and their annotated locations for XP_011521482.1

    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  26. XM_017023383.2XP_016878872.1  protein BANP isoform X20

    Conserved Domains (1) summary
    smart01025
    Location:2396
    BEN; The BEN domain is found in diverse animal proteins
  27. XM_011523183.2XP_011521485.1  protein BANP isoform X14

    Conserved Domains (1) summary
    smart01025
    Location:154227
    BEN; The BEN domain is found in diverse animal proteins
  28. XM_024450329.1XP_024306097.1  protein BANP isoform X16

    Conserved Domains (1) summary
    smart01025
    Location:115188
    BEN; The BEN domain is found in diverse animal proteins
  29. XM_024450330.1XP_024306098.1  protein BANP isoform X17

    Conserved Domains (1) summary
    smart01025
    Location:115188
    BEN; The BEN domain is found in diverse animal proteins
  30. XM_024450325.1XP_024306093.1  protein BANP isoform X10

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  31. XM_011523184.2XP_011521486.1  protein BANP isoform X15

    Conserved Domains (1) summary
    smart01025
    Location:142215
    BEN; The BEN domain is found in diverse animal proteins
  32. XM_011523174.2XP_011521476.1  protein BANP isoform X1

    See identical proteins and their annotated locations for XP_011521476.1

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  33. XM_011523177.2XP_011521479.1  protein BANP isoform X1

    See identical proteins and their annotated locations for XP_011521479.1

    Conserved Domains (1) summary
    smart01025
    Location:263336
    BEN; The BEN domain is found in diverse animal proteins
  34. XM_024450321.1XP_024306089.1  protein BANP isoform X4

    Conserved Domains (1) summary
    smart01025
    Location:257330
    BEN; The BEN domain is found in diverse animal proteins
  35. XM_024450333.1XP_024306101.1  protein BANP isoform X19

    Conserved Domains (1) summary
    smart01025
    Location:2396
    BEN; The BEN domain is found in diverse animal proteins
  36. XM_017023382.1XP_016878871.1  protein BANP isoform X18

RNA

  1. XR_933350.2 RNA Sequence

  2. XR_933352.2 RNA Sequence

  3. XR_001751945.1 RNA Sequence

  4. XR_933353.2 RNA Sequence

  5. XR_001751946.1 RNA Sequence

  6. XR_001751947.1 RNA Sequence

  7. XR_001751948.1 RNA Sequence

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