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HPF1 histone PARylation factor 1 [ Homo sapiens (human) ]

Gene ID: 54969, updated on 6-Nov-2022

Summary

Official Symbol
HPF1provided by HGNC
Official Full Name
histone PARylation factor 1provided by HGNC
Primary source
HGNC:HGNC:26051
See related
Ensembl:ENSG00000056050 MIM:616614; AllianceGenome:HGNC:26051
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf27
Summary
Enables chromatin binding activity and histone binding activity. Involved in double-strand break repair; peptidyl-serine ADP-ribosylation; and regulation of protein modification process. Located in chromatin; nucleus; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 6.3), endometrium (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

See HPF1 in Genome Data Viewer
Location:
4q33
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (169729470..169757944, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (173089586..173118075, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (170650621..170679095, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NIMA related kinase 1 Neighboring gene chloride voltage-gated channel 3 Neighboring gene Sharpr-MPRA regulatory region 12659 Neighboring gene uncharacterized LOC107986240 Neighboring gene prostaglandin E synthase 3 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20534, FLJ33423, FLJ42042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables poly-ADP-D-ribose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein ADP-ribosyltransferase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of DNA damage IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone PARylation factor 1
Names
UPF0609 protein C4orf27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017867.3NP_060337.2  histone PARylation factor 1

    See identical proteins and their annotated locations for NP_060337.2

    Status: VALIDATED

    Source sequence(s)
    AC106878, AK000541, BM905677, CB141427, DN990093
    Consensus CDS
    CCDS3813.1
    UniProtKB/Swiss-Prot
    Q9NWY4
    Related
    ENSP00000406598.1, ENST00000393381.3
    Conserved Domains (1) summary
    pfam10228
    Location:78328
    DUF2228; Uncharacterized conserved protein (DUF2228)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    169729470..169757944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    173089586..173118075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)