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HPF1 histone PARylation factor 1 [ Homo sapiens (human) ]

Gene ID: 54969, updated on 3-Jan-2019

Summary

Official Symbol
HPF1provided by HGNC
Official Full Name
histone PARylation factor 1provided by HGNC
Primary source
HGNC:HGNC:26051
See related
Ensembl:ENSG00000056050 MIM:616614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf27
Expression
Ubiquitous expression in brain (RPKM 6.3), endometrium (RPKM 6.0) and 25 other tissues See more
Orthologs

Genomic context

See HPF1 in Genome Data Viewer
Location:
4q33
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (169729468..169757942, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (170650619..170679093, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene NIMA related kinase 1 Neighboring gene chloride voltage-gated channel 3 Neighboring gene uncharacterized LOC107986240 Neighboring gene prostaglandin E synthase 3 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20534, FLJ33423, FLJ42042

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
poly-ADP-D-ribose binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein ADP-ribosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein ADP-ribosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
histone PARylation factor 1
Names
UPF0609 protein C4orf27

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017867.3NP_060337.2  histone PARylation factor 1

    See identical proteins and their annotated locations for NP_060337.2

    Status: VALIDATED

    Source sequence(s)
    AC106878, AK000541, BM905677, CB141427, DN990093
    Consensus CDS
    CCDS3813.1
    UniProtKB/Swiss-Prot
    Q9NWY4
    Related
    ENSP00000406598.1, ENST00000393381.2
    Conserved Domains (1) summary
    pfam10228
    Location:79328
    DUF2228; uncharacterized conserved protein (DUF2228)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    169729468..169757942 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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