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slc25a12 solute carrier family 25 member 12 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 549674, updated on 4-Jan-2025

Summary

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Official Symbol
slc25a12provided by Xenbase
Official Full Name
solute carrier family 25 member 12provided by Xenbase
Primary source
Xenbase:XB-GENE-1002100
See related
Ensembl:ENSXETG00000018810 AllianceGenome:Xenbase:XB-GENE-1002100
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
aralar; aralar1; slc25a13
Summary
Predicted to enable L-aspartate transmembrane transporter activity and L-glutamate transmembrane transporter activity. Predicted to be involved in L-glutamate transmembrane transport; aspartate transmembrane transport; and malate-aspartate shuttle. Predicted to act upstream of or within transmembrane transport. Predicted to be located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Asperger syndrome; autistic disorder; and developmental and epileptic encephalopathy 39. Orthologous to human SLC25A12 (solute carrier family 25 member 12). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See slc25a12 in Genome Data Viewer
Location:
chromosome: 9
Exon count:
19
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 9 NC_030685.2 (67614641..67708497)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 9 NC_030685.1 (62477981..62572399)

Chromosome 9 - NC_030685.2Genomic Context describing neighboring genes Neighboring gene methionyl aminopeptidase type 1D (mitochondrial) Neighboring gene histone acetyltransferase 1 Neighboring gene dynein, cytoplasmic 1, intermediate chain 2 Neighboring gene cytochrome b reductase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in malate-aspartate shuttle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within malate-aspartate shuttle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial; calcium-binding mitochondrial carrier protein Aralar1
Names
solute carrier family 25 (aspartate/glutamate carrier), member 12
solute carrier family 25 (mitochondrial carrier, Aralar), member 12
solute carrier family 25, member 13 (citrin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001016920.2 → NP_001016920.1  electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

    See identical proteins and their annotated locations for NP_001016920.1

    Status: PROVISIONAL

    Source sequence(s)
    CR848162
    UniProtKB/TrEMBL
    Q05B08, Q28EN1
    Conserved Domains (1) summary
    pfam00153
    Location:338 → 430
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030685.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    67614641..67708497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012970445.2 → XP_012825899.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X2

    UniProtKB/TrEMBL
    B2GUQ3, F6X4X7
    Related
    ENSXETP00000040789.3, ENSXETT00000040789.5
    Conserved Domains (4) summary
    cd15897
    Location:13 → 46
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:13 → 184
    EFh_PEF; The penta-EF hand (PEF) family
    pfam00153
    Location:513 → 603
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:13 → 78
    EF-hand_7; EF-hand domain pair

  2. XM_012970444.3 → XP_012825898.1  calcium-binding mitochondrial carrier protein Aralar1 isoform X1

    UniProtKB/TrEMBL
    A0A6I8RUY3, B2GUQ3
    Related
    ENSXETP00000088672.2, ENSXETT00000070621.2
    Conserved Domains (4) summary
    cd15897
    Location:13 → 46
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:13 → 184
    EFh_PEF; The penta-EF hand (PEF) family
    pfam00153
    Location:513 → 603
    Mito_carr; Mitochondrial carrier protein
    pfam13499
    Location:13 → 78
    EF-hand_7; EF-hand domain pair
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut