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TIPIN TIMELESS interacting protein [ Homo sapiens (human) ]

Gene ID: 54962, updated on 10-Oct-2024

Summary

Official Symbol
TIPINprovided by HGNC
Official Full Name
TIMELESS interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:30750
See related
Ensembl:ENSG00000075131 MIM:610716; AllianceGenome:HGNC:30750
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression
Broad expression in testis (RPKM 3.8), lymph node (RPKM 1.8) and 24 other tissues See more
Orthologs
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Genomic context

See TIPIN in Genome Data Viewer
Location:
15q22.31
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (66336191..66386717, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (64157927..64208168, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (66628529..66679055, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene multiple EGF like domains 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66340493-66341368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66349054-66349554 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66357857-66358057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66358200-66358762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66365553-66366053 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:66371850-66372818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:66372819-66373785 Neighboring gene microRNA 4311 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66388655-66389435 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66408056-66408295 Neighboring gene Sharpr-MPRA regulatory region 9514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66435333-66436223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66460026-66460820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66461585-66462085 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr15:66472833-66473489 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66591355-66591855 Neighboring gene DIS3L antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66630872-66631107 Neighboring gene DIS3 like exosome 3'-5' exoribonuclease Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9611 Neighboring gene small Cajal body-specific RNA 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9612 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6564 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:66681899-66682075 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6565 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr15:66696135-66696928 Neighboring gene ribosomal protein L9 pseudogene 25 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:66720755-66721254 Neighboring gene mitogen-activated protein kinase kinase 1 Neighboring gene ATP synthase membrane subunit f pseudogene 6 Neighboring gene ribosomal protein L35a pseudogene 32

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ20516

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA replication checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic intra-S DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of nuclear cell cycle DNA replication TAS
Traceable Author Statement
more info
PubMed 
involved_in replication fork arrest IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in replication fork processing IEA
Inferred from Electronic Annotation
more info
 
involved_in response to UV IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of replication fork protection complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
TIMELESS-interacting protein
Names
CSM3 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289986.2NP_001276915.1  TIMELESS-interacting protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC055855
    UniProtKB/TrEMBL
    B4DRF3
    Conserved Domains (1) summary
    pfam07962
    Location:247
    Swi3; Replication Fork Protection Component Swi3
  2. NM_001398281.1NP_001385210.1  TIMELESS-interacting protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Consensus CDS
    CCDS10215.1
    UniProtKB/Swiss-Prot
    B2CW64, Q9BVW5, Q9NWZ6
    Conserved Domains (1) summary
    pfam07962
    Location:66148
    Swi3; Replication Fork Protection Component Swi3
  3. NM_001398282.1NP_001385211.1  TIMELESS-interacting protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Consensus CDS
    CCDS10215.1
    UniProtKB/Swiss-Prot
    B2CW64, Q9BVW5, Q9NWZ6
    Conserved Domains (1) summary
    pfam07962
    Location:66148
    Swi3; Replication Fork Protection Component Swi3
  4. NM_001398283.1NP_001385212.1  TIMELESS-interacting protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Consensus CDS
    CCDS10215.1
    UniProtKB/Swiss-Prot
    B2CW64, Q9BVW5, Q9NWZ6
    Related
    ENSP00000457406.1, ENST00000562124.5
    Conserved Domains (1) summary
    pfam07962
    Location:66148
    Swi3; Replication Fork Protection Component Swi3
  5. NM_001398284.1NP_001385213.1  TIMELESS-interacting protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Consensus CDS
    CCDS10215.1
    UniProtKB/Swiss-Prot
    B2CW64, Q9BVW5, Q9NWZ6
    Conserved Domains (1) summary
    pfam07962
    Location:66148
    Swi3; Replication Fork Protection Component Swi3
  6. NM_001398285.1NP_001385214.1  TIMELESS-interacting protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Conserved Domains (1) summary
    pfam07962
    Location:247
    Swi3; Replication Fork Protection Component Swi3
  7. NM_001398286.1NP_001385215.1  TIMELESS-interacting protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Conserved Domains (1) summary
    pfam07962
    Location:247
    Swi3; Replication Fork Protection Component Swi3
  8. NM_001398287.1NP_001385216.1  TIMELESS-interacting protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Conserved Domains (1) summary
    pfam07962
    Location:247
    Swi3; Replication Fork Protection Component Swi3
  9. NM_017858.3NP_060328.3  TIMELESS-interacting protein isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC055855
    Consensus CDS
    CCDS10215.1
    UniProtKB/Swiss-Prot
    B2CW64, Q9BVW5, Q9NWZ6
    UniProtKB/TrEMBL
    H3BU04
    Related
    ENSP00000261881.4, ENST00000261881.9
    Conserved Domains (1) summary
    pfam07962
    Location:66148
    Swi3; Replication Fork Protection Component Swi3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    66336191..66386717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022390.2XP_016877879.1  TIMELESS-interacting protein isoform X1

    UniProtKB/Swiss-Prot
    B2CW64, Q9BVW5, Q9NWZ6
    UniProtKB/TrEMBL
    H3BU04
    Conserved Domains (1) summary
    pfam07962
    Location:66148
    Swi3; Replication Fork Protection Component Swi3
  2. XM_024449971.2XP_024305739.1  TIMELESS-interacting protein isoform X1

    UniProtKB/Swiss-Prot
    B2CW64, Q9BVW5, Q9NWZ6
    UniProtKB/TrEMBL
    H3BU04
    Conserved Domains (1) summary
    pfam07962
    Location:66148
    Swi3; Replication Fork Protection Component Swi3
  3. XM_047432779.1XP_047288735.1  TIMELESS-interacting protein isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    64157927..64208168 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378343.1XP_054234318.1  TIMELESS-interacting protein isoform X1

  2. XM_054378344.1XP_054234319.1  TIMELESS-interacting protein isoform X1

  3. XM_054378345.1XP_054234320.1  TIMELESS-interacting protein isoform X2