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SSH3 slingshot protein phosphatase 3 [ Homo sapiens (human) ]

Gene ID: 54961, updated on 5-Sep-2021

Summary

Official Symbol
SSH3provided by HGNC
Official Full Name
slingshot protein phosphatase 3provided by HGNC
Primary source
HGNC:HGNC:30581
See related
Ensembl:ENSG00000172830 MIM:606780
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSH3L
Summary
The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in urinary bladder (RPKM 17.7), prostate (RPKM 14.2) and 25 other tissues See more
Orthologs
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Genomic context

See SSH3 in Genome Data Viewer
Location:
11q13.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (67303478..67312607)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67071001..67080063)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor kinase 2 Neighboring gene ankyrin repeat domain 13D Neighboring gene uncharacterized LOC100130987 Neighboring gene DNA polymerase delta 4, accessory subunit Neighboring gene RN7SK pseudogene 239

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10928, FLJ20515, FLJ42240

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase Slingshot homolog 3
Names
SSH-3L
SSH-like protein 3
hSSH-3L
slingshot 3
slingshot homolog 3
NP_060327.3
XP_016873431.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017857.4NP_060327.3  protein phosphatase Slingshot homolog 3

    See identical proteins and their annotated locations for NP_060327.3

    Status: VALIDATED

    Source sequence(s)
    AK074432, AP001885, BU689839
    Consensus CDS
    CCDS8157.1
    UniProtKB/Swiss-Prot
    Q8TE77
    UniProtKB/TrEMBL
    A0A024R5J4
    Related
    ENSP00000312081.4, ENST00000308127.9
    Conserved Domains (3) summary
    cd11652
    Location:3259
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:329464
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:272320
    DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    67303478..67312607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017942.1XP_016873431.1  protein phosphatase Slingshot homolog 3 isoform X1

    Related
    ENSP00000365948.6, ENST00000376757.9
    Conserved Domains (3) summary
    cd11652
    Location:1159
    SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases
    cd00127
    Location:229364
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    pfam08766
    Location:172220
    DEK_C; DEK C terminal domain

RNA

  1. XR_001747913.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_018276.2: Suppressed sequence

    Description
    NM_018276.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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