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TXNL4B thioredoxin like 4B [ Homo sapiens (human) ]

Gene ID: 54957, updated on 7-Dec-2018

Summary

Official Symbol
TXNL4Bprovided by HGNC
Official Full Name
thioredoxin like 4Bprovided by HGNC
Primary source
HGNC:HGNC:26041
See related
Ensembl:ENSG00000140830 MIM:617722
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLP; Dim2
Expression
Ubiquitous expression in ovary (RPKM 7.1), testis (RPKM 6.7) and 25 other tissues See more
Orthologs

Genomic context

See TXNL4B in Genome Data Viewer
Location:
16q22.2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (72044261..72094316, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (72118756..72128215, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATP synthase F1 subunit alpha pseudogene 3 Neighboring gene dihydroorotate dehydrogenase (quinone) Neighboring gene haptoglobin Neighboring gene haptoglobin-related protein Neighboring gene DEAH-box helicase 38 Neighboring gene polyamine modulated factor 1 binding protein 1 Neighboring gene uncharacterized LOC105371341

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.
NHGRI GWA Catalog
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of thioredoxin-like 4B (TXNL4B) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20511

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
thioredoxin-like protein 4B
Names
Dim1-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142317.1NP_001135789.1  thioredoxin-like protein 4B isoform 1

    See identical proteins and their annotated locations for NP_001135789.1

    Status: VALIDATED

    Source sequence(s)
    AC009087, BC009646, DA499499
    Consensus CDS
    CCDS10906.1
    UniProtKB/Swiss-Prot
    Q9NX01
    Related
    ENSP00000408130.1, ENST00000423037.5
    Conserved Domains (1) summary
    cd02986
    Location:10123
    DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...
  2. NM_001142318.1NP_001135790.1  thioredoxin-like protein 4B isoform 1

    See identical proteins and their annotated locations for NP_001135790.1

    Status: VALIDATED

    Source sequence(s)
    AC009087, BC009646, CD517462
    Consensus CDS
    CCDS10906.1
    UniProtKB/Swiss-Prot
    Q9NX01
    Related
    ENSP00000392310.2, ENST00000426362.6
    Conserved Domains (1) summary
    cd02986
    Location:10123
    DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...
  3. NM_001324354.1NP_001311283.1  thioredoxin-like protein 4B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009087
    Related
    ENSP00000457699.1, ENST00000569767.1
  4. NM_001324355.1NP_001311284.1  thioredoxin-like protein 4B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009087, BM849401
  5. NM_017853.3NP_060323.1  thioredoxin-like protein 4B isoform 1

    See identical proteins and their annotated locations for NP_060323.1

    Status: VALIDATED

    Source sequence(s)
    AC009087, BC009646, BP355646
    Consensus CDS
    CCDS10906.1
    UniProtKB/Swiss-Prot
    Q9NX01
    Related
    ENSP00000268483.3, ENST00000268483.7
    Conserved Domains (1) summary
    cd02986
    Location:10123
    DLP; Dim1 family, Dim1-like protein (DLP) subfamily; DLP is a novel protein which shares 38% sequence identity to Dim1. Like Dim1, it is also implicated in pre-mRNA splicing and cell cycle progression. DLP is located in the nucleus and has been shown to ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    72044261..72094316 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017023377.2XP_016878866.1  thioredoxin-like protein 4B isoform X1

    Related
    ENSP00000454635.1, ENST00000562153.5
    Conserved Domains (1) summary
    cl00388
    Location:1098
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
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