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COMMD8 COMM domain containing 8 [ Homo sapiens (human) ]

Gene ID: 54951, updated on 10-Oct-2019

Summary

Official Symbol
COMMD8provided by HGNC
Official Full Name
COMM domain containing 8provided by HGNC
Primary source
HGNC:HGNC:26036
See related
Ensembl:ENSG00000169019 MIM:616656
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. [provided by RefSeq, Jul 2016]
Expression
Ubiquitous expression in kidney (RPKM 8.5), testis (RPKM 8.1) and 25 other tissues See more
Orthologs

Genomic context

See COMMD8 in Genome Data Viewer
Location:
4p12
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (47450787..47463730, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (47452815..47465676, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid type A receptor subunit beta1 Neighboring gene uncharacterized LOC105374442 Neighboring gene uncharacterized LOC107986276 Neighboring gene uncharacterized LOC107986277 Neighboring gene ribosomal protein L21 pseudogene 52 Neighboring gene ATPase phospholipid transporting 10D (putative)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20502

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
COMM domain-containing protein 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329668.1NP_001316597.1  COMM domain-containing protein 8 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC107398, BC015145
    UniProtKB/Swiss-Prot
    Q9NX08
    Conserved Domains (1) summary
    cd04756
    Location:7180
    Commd8; COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  2. NM_017845.5NP_060315.1  COMM domain-containing protein 8 isoform 1

    See identical proteins and their annotated locations for NP_060315.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC107398
    Consensus CDS
    CCDS3475.1
    UniProtKB/Swiss-Prot
    Q9NX08
    Related
    ENSP00000370984.4, ENST00000381571.6
    Conserved Domains (1) summary
    cd04756
    Location:7182
    Commd8; COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    47450787..47463730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008330.1XP_016863819.1  COMM domain-containing protein 8 isoform X1

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