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LPCAT2 lysophosphatidylcholine acyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 54947, updated on 3-May-2020

Summary

Official Symbol
LPCAT2provided by HGNC
Official Full Name
lysophosphatidylcholine acyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:26032
See related
Ensembl:ENSG00000087253 MIM:612040
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AYTL1; AGPAT11; LysoPAFAT
Summary
This gene encodes a member of the lysophospholipid acyltransferase family. The encoded enzyme may function in two ways: to catalyze the biosynthesis of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) from 1-O-alkyl-sn-glycero-3-phosphocholine, and to catalyze the synthesis of glycerophospholipid precursors from arachidonyl-CoA and lysophosphatidylcholine. The encoded protein may function in membrane biogenesis and production of platelet-activating factor in inflammatory cells. The enzyme may localize to the endoplasmic reticulum and the Golgi. [provided by RefSeq, Feb 2009]
Expression
Broad expression in thyroid (RPKM 50.3), bone marrow (RPKM 11.0) and 19 other tissues See more
Orthologs

Genomic context

See LPCAT2 in Genome Data Viewer
Location:
16q12.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (55509055..55586666)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (55542913..55620582)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MMP2 antisense RNA 1 Neighboring gene matrix metallopeptidase 2 Neighboring gene calpain small subunit 2 Neighboring gene solute carrier family 6 member 2 Neighboring gene uncharacterized LOC105371280

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20481, DKFZp686H22112

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-acylglycerol-3-phosphate O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
1-acylglycerophosphocholine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
1-acylglycerophosphocholine O-acyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
1-alkylglycerophosphocholine O-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
membrane organization ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylcholine acyl-chain remodeling IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine acyl-chain remodeling TAS
Traceable Author Statement
more info
 
platelet activating factor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi stack ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lysophosphatidylcholine acyltransferase 2
Names
1-AGP acyltransferase 11
1-AGPAT 11
1-acylglycerol-3-phosphate O-acyltransferase 11
1-acylglycerophosphocholine O-acyltransferase
1-alkylglycerophosphocholine O-acetyltransferase
LPAAT-alpha
LPC acyltransferase 2
LPCAT-2
acetyl-CoA:lyso-PAF acetyltransferase
acetyl-CoA:lyso-platelet-activating factor acetyltransferase
acyl-CoA:lysophosphatidylcholine acyltransferase 2
acyltransferase-like 1
lyso-PAF acetyltransferase
lyso-platelet-activating factor (PAF) acetyltransferase
lysoPC acyltransferase 2
lysophosphatidic acid acyltransferase alpha
NP_060309.2
XP_005256063.1
XP_011521471.1
XP_016878865.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017839.5NP_060309.2  lysophosphatidylcholine acyltransferase 2

    See identical proteins and their annotated locations for NP_060309.2

    Status: REVIEWED

    Source sequence(s)
    AI915099, AW366682, BC002472, BC005981, BX641069
    Consensus CDS
    CCDS10753.1
    UniProtKB/Swiss-Prot
    Q7L5N7
    Related
    ENSP00000262134.5, ENST00000262134.10
    Conserved Domains (2) summary
    cd07991
    Location:116327
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    cl25352
    Location:374494
    EFh_PEF; The penta-EF hand (PEF) family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    55509055..55586666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256006.3XP_005256063.1  lysophosphatidylcholine acyltransferase 2 isoform X2

    Conserved Domains (2) summary
    cd07991
    Location:116287
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:103254
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
  2. XM_017023376.1XP_016878865.1  lysophosphatidylcholine acyltransferase 2 isoform X1

    Conserved Domains (4) summary
    cd07991
    Location:60271
    LPLAT_LPCAT1-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like
    COG0204
    Location:47198
    PlsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]
    cd00051
    Location:340402
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:340401
    EF-hand_7; EF-hand domain pair
  3. XM_011523169.3XP_011521471.1  lysophosphatidylcholine acyltransferase 2 isoform X3

    UniProtKB/Swiss-Prot
    Q7L5N7
    Conserved Domains (3) summary
    cd00051
    Location:126188
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:126187
    EF-hand_7; EF-hand domain pair
    cl17185
    Location:257
    LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
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