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SLC41A3 solute carrier family 41 member 3 [ Homo sapiens (human) ]

Gene ID: 54946, updated on 7-Jun-2020

Summary

Official Symbol
SLC41A3provided by HGNC
Official Full Name
solute carrier family 41 member 3provided by HGNC
Primary source
HGNC:HGNC:31046
See related
Ensembl:ENSG00000114544 MIM:610803
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC41A1-L2
Expression
Ubiquitous expression in testis (RPKM 23.3), ovary (RPKM 19.3) and 25 other tissues See more
Orthologs

Genomic context

See SLC41A3 in Genome Data Viewer
Location:
3q21.2-q21.3
Exon count:
14
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (126006357..126101550, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (125725200..125820398, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase like Neighboring gene fibrosin like 1 pseudogene Neighboring gene rhophilin associated tail protein 1B Neighboring gene uncharacterized LOC105374085 Neighboring gene uncharacterized LOC112267887 Neighboring gene ALDH1L1 antisense RNA 1 Neighboring gene aldehyde dehydrogenase 1 family member L1 Neighboring gene uncharacterized LOC105374083 Neighboring gene RNA, U1 small nuclear 30, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20473

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
solute carrier family 41 member 3
Names
SLC41A1-like 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008485.2NP_001008485.2  solute carrier family 41 member 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC079848, AC092903, AC117422
    Consensus CDS
    CCDS33843.1
    Related
    ENSP00000326070.6, ENST00000315891.10
  2. NM_001008486.2NP_001008486.2  solute carrier family 41 member 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon and uses alternate splicing in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 3) with a unique C-terminus.
    Source sequence(s)
    AC079848, AC092903, AC117422
    Consensus CDS
    CCDS33842.1
    Related
    ENSP00000264471.6, ENST00000346785.9
  3. NM_001008487.2NP_001008487.1  solute carrier family 41 member 3 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) utilizes an alternate 5' coding exon, compared to variant 1, resulting in the shortest protein (isoform 4) that has a unique N-terminus compared to isoform 1.
    Source sequence(s)
    AC092903, AC117422
    Consensus CDS
    CCDS33844.1
    UniProtKB/Swiss-Prot
    Q96GZ6
    Related
    ENSP00000373092.2, ENST00000383598.6
    Conserved Domains (1) summary
    pfam01769
    Location:80211
    MgtE; Divalent cation transporter
  4. NM_001164475.2NP_001157947.1  solute carrier family 41 member 3 isoform 5

    See identical proteins and their annotated locations for NP_001157947.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and coding sequences compared to variant 1. The resulting isoform (5) is shorter at the N-terminus and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079848, AC092903, AC117422
    Consensus CDS
    CCDS54635.1
    UniProtKB/Swiss-Prot
    Q96GZ6
    Related
    ENSP00000427409.1, ENST00000508835.5
    Conserved Domains (1) summary
    pfam01769
    Location:1121
    MgtE; Divalent cation transporter
  5. NM_017836.4NP_060306.4  solute carrier family 41 member 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splicing in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2) with a unique C-terminus.
    Source sequence(s)
    AC079848, AC092903, AC117422
    Consensus CDS
    CCDS43144.1
    Related
    ENSP00000353533.4, ENST00000360370.8

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    126006357..126101550 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005247563.2XP_005247620.1  solute carrier family 41 member 3 isoform X2

    See identical proteins and their annotated locations for XP_005247620.1

    UniProtKB/Swiss-Prot
    Q96GZ6
    Conserved Domains (1) summary
    pfam01769
    Location:319456
    MgtE; Divalent cation transporter
  2. XM_017006707.1XP_016862196.1  solute carrier family 41 member 3 isoform X5

    UniProtKB/Swiss-Prot
    Q96GZ6
    Conserved Domains (1) summary
    pfam01769
    Location:106238
    MgtE; Divalent cation transporter
  3. XM_017006708.1XP_016862197.1  solute carrier family 41 member 3 isoform X8

  4. XM_005247559.1XP_005247616.1  solute carrier family 41 member 3 isoform X1

    See identical proteins and their annotated locations for XP_005247616.1

    Conserved Domains (1) summary
    pfam01769
    Location:334471
    MgtE; Divalent cation transporter
  5. XM_005247564.1XP_005247621.1  solute carrier family 41 member 3 isoform X3

    Conserved Domains (1) summary
    pfam01769
    Location:106252
    MgtE; Divalent cation transporter
  6. XM_006713681.3XP_006713744.1  solute carrier family 41 member 3 isoform X2

    See identical proteins and their annotated locations for XP_006713744.1

    UniProtKB/Swiss-Prot
    Q96GZ6
    Conserved Domains (1) summary
    pfam01769
    Location:319456
    MgtE; Divalent cation transporter
  7. XM_024453609.1XP_024309377.1  solute carrier family 41 member 3 isoform X5

    Conserved Domains (1) summary
    pfam01769
    Location:106238
    MgtE; Divalent cation transporter
  8. XM_005247562.1XP_005247619.1  solute carrier family 41 member 3 isoform X2

    See identical proteins and their annotated locations for XP_005247619.1

    UniProtKB/Swiss-Prot
    Q96GZ6
    Conserved Domains (1) summary
    pfam01769
    Location:319456
    MgtE; Divalent cation transporter
  9. XM_017006706.1XP_016862195.1  solute carrier family 41 member 3 isoform X5

    UniProtKB/Swiss-Prot
    Q96GZ6
    Conserved Domains (1) summary
    pfam01769
    Location:106238
    MgtE; Divalent cation transporter
  10. XM_024453610.1XP_024309378.1  solute carrier family 41 member 3 isoform X7

    Conserved Domains (1) summary
    pfam01769
    Location:283420
    MgtE; Divalent cation transporter
  11. XM_017006709.1XP_016862198.1  solute carrier family 41 member 3 isoform X8

  12. XM_017006705.1XP_016862194.1  solute carrier family 41 member 3 isoform X1

    Conserved Domains (1) summary
    pfam01769
    Location:334471
    MgtE; Divalent cation transporter
  13. XM_005247565.2XP_005247622.1  solute carrier family 41 member 3 isoform X6

    Conserved Domains (1) summary
    pfam01769
    Location:293430
    MgtE; Divalent cation transporter
  14. XM_011512945.1XP_011511247.1  solute carrier family 41 member 3 isoform X4

    Conserved Domains (1) summary
    pfam01769
    Location:308445
    MgtE; Divalent cation transporter
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