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RNF125 ring finger protein 125 [ Homo sapiens (human) ]

Gene ID: 54941, updated on 1-Aug-2020

Summary

Official Symbol
RNF125provided by HGNC
Official Full Name
ring finger protein 125provided by HGNC
Primary source
HGNC:HGNC:21150
See related
Ensembl:ENSG00000101695 MIM:610432
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNORS; TRAC1; TRAC-1
Summary
This gene encodes a novel E3 ubiquitin ligase that contains a RING finger domain in the N-terminus and three zinc-binding and one ubiquitin-interacting motif in the C-terminus. As a result of myristoylation, this protein associates with membranes and is primarily localized to intracellular membrane systems. The encoded protein may function as a positive regulator in the T-cell receptor signaling pathway. [provided by RefSeq, Mar 2012]
Expression
Ubiquitous expression in fat (RPKM 4.1), bone marrow (RPKM 4.0) and 25 other tissues See more
Orthologs

Genomic context

See RNF125 in Genome Data Viewer
Location:
18q12.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (32018585..32090756)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (29598445..29653154)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene epsin 2 pseudogene Neighboring gene phosphogluconate dehydrogenase pseudogene 1 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 44 Neighboring gene ribosomal protein S15a pseudogene 35 Neighboring gene ring finger protein 138 Neighboring gene RNA, 5S ribosomal pseudogene 453

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cells expressing RNF125/TRAC1 downregulate the levels of HIV-1 gp120 expression PubMed
Tat tat HIV-1 Tat 47-59 peptide upregulates gene expression of ring finger protein 125, E3 ubiquitin protein ligase (RNF125) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20456, MGC21737

Gene Ontology Provided by GOA

Function Evidence Code Pubs
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin conjugating enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of RIG-I signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
VCP-NPL4-UFD1 AAA ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
VCP-NPL4-UFD1 AAA ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF125
Names
T-cell RING activation protein 1
T-cell ring protein identified in activation screen
ring finger protein 125, E3 ubiquitin protein ligase
NP_060301.2
XP_011524347.1
XP_011524348.1
XP_011524349.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042056.1 RefSeqGene

    Range
    5344..59738
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017831.4NP_060301.2  E3 ubiquitin-protein ligase RNF125

    See identical proteins and their annotated locations for NP_060301.2

    Status: REVIEWED

    Source sequence(s)
    AC011825, AK000463, BC012021, BI666910
    Consensus CDS
    CCDS11902.1
    UniProtKB/Swiss-Prot
    Q96EQ8
    Related
    ENSP00000217740.3, ENST00000217740.4
    Conserved Domains (2) summary
    cd00162
    Location:3677
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam05605
    Location:141173
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    32018585..32090756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526047.3XP_011524349.1  E3 ubiquitin-protein ligase RNF125 isoform X3

    Conserved Domains (1) summary
    cd00162
    Location:3677
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_011526045.3XP_011524347.1  E3 ubiquitin-protein ligase RNF125 isoform X1

    Conserved Domains (2) summary
    cd00162
    Location:3677
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam05605
    Location:141173
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
  3. XM_011526046.3XP_011524348.1  E3 ubiquitin-protein ligase RNF125 isoform X2

    Conserved Domains (2) summary
    cd00162
    Location:3677
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam05605
    Location:141168
    zf-Di19; Drought induced 19 protein (Di19), zinc-binding
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