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PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A [ Homo sapiens (human) ]

Gene ID: 5494, updated on 6-Nov-2022

Summary

Official Symbol
PPM1Aprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1Aprovided by HGNC
Primary source
HGNC:HGNC:9275
See related
Ensembl:ENSG00000100614 MIM:606108; AllianceGenome:HGNC:9275
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP2CA; PP2Calpha; PP2C-ALPHA
Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 10.2), brain (RPKM 9.4) and 25 other tissues See more
Orthologs
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Genomic context

See PPM1A in Genome Data Viewer
Location:
14q23.1
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (60245750..60299087)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (54452043..54505381)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (60712468..60765805)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 2 Neighboring gene uncharacterized LOC101927702 Neighboring gene long intergenic non-protein coding RNA 2322 Neighboring gene GNRHR2 pseudogene 1 Neighboring gene RNA binding motif protein 8B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A) by siRNA ehnahces HIV-1 gene expression in resting CD4+ T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9201, FLJ42306

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in N-terminal protein myristoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of SMAD protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-threonine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein phosphatase 1A
NP_066283.1
NP_808820.1
NP_808821.2
XP_011535183.1
XP_011535185.1
XP_016876872.1
XP_024305405.1
XP_047287455.1
XP_047287456.1
XP_047287457.1
XP_047287458.1
XP_047287459.1
XP_047287460.1
XP_047287461.1
XP_047287462.1
XP_047287463.1
XP_047287464.1
XP_047287465.1
XP_047287466.1
XP_047287467.1
XP_047287468.1
XP_047287469.1
XP_047287470.1
XP_047287471.1
XP_047287472.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029698.1 RefSeqGene

    Range
    8470..58336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021003.5NP_066283.1  protein phosphatase 1A isoform 1

    See identical proteins and their annotated locations for NP_066283.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes isoform 1.
    Source sequence(s)
    AI076736, AL132778, AL157756, BC063243, DA439296
    Consensus CDS
    CCDS9744.1
    UniProtKB/Swiss-Prot
    O75551, P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Related
    ENSP00000378514.4, ENST00000395076.9
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285363
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  2. NM_177951.3NP_808820.1  protein phosphatase 1A isoform 2

    See identical proteins and their annotated locations for NP_808820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon within the 5' UTR and lacks a few of 3' exons but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AF070670, AL157756, CB156710, DA439296
    Consensus CDS
    CCDS9745.1
    UniProtKB/Swiss-Prot
    P35813
    Related
    ENSP00000314850.3, ENST00000325658.3
    Conserved Domains (2) summary
    pfam00481
    Location:22284
    PP2C; Protein phosphatase 2C
    cl29762
    Location:285317
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  3. NM_177952.3NP_808821.2  protein phosphatase 1A isoform 3

    See identical proteins and their annotated locations for NP_808821.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, as compared to variant 1. It encodes isoform 3, which has a distinct and longer N-terminus, as compared to isoform 1.
    Source sequence(s)
    AI076736, AK097843, AK313337, AL132778, AL157756, BC063243
    Consensus CDS
    CCDS45120.1
    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    B2R8E4
    Related
    ENSP00000327255.3, ENST00000325642.7
    Conserved Domains (2) summary
    pfam00481
    Location:95357
    PP2C; Protein phosphatase 2C
    pfam07830
    Location:358433
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    60245750..60299087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431505.1XP_047287461.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  2. XM_047431508.1XP_047287464.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  3. XM_047431511.1XP_047287467.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  4. XM_047431512.1XP_047287468.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  5. XM_047431516.1XP_047287472.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  6. XM_047431499.1XP_047287455.1  protein phosphatase 1A isoform X1

  7. XM_047431501.1XP_047287457.1  protein phosphatase 1A isoform X1

  8. XM_017021383.2XP_016876872.1  protein phosphatase 1A isoform X1

  9. XM_047431507.1XP_047287463.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  10. XM_047431513.1XP_047287469.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  11. XM_047431515.1XP_047287471.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  12. XM_024449637.2XP_024305405.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285363
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  13. XM_047431500.1XP_047287456.1  protein phosphatase 1A isoform X1

  14. XM_047431510.1XP_047287466.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  15. XM_047431506.1XP_047287462.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  16. XM_047431514.1XP_047287470.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  17. XM_011536883.2XP_011535185.1  protein phosphatase 1A isoform X3

    See identical proteins and their annotated locations for XP_011535185.1

    UniProtKB/Swiss-Prot
    O75551, P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285363
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  18. XM_047431509.1XP_047287465.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  19. XM_047431503.1XP_047287459.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  20. XM_047431504.1XP_047287460.1  protein phosphatase 1A isoform X3

    UniProtKB/Swiss-Prot
    O75551
    UniProtKB/TrEMBL
    A0A024R6A5
  21. XM_011536881.4XP_011535183.1  protein phosphatase 1A isoform X3

    See identical proteins and their annotated locations for XP_011535183.1

    UniProtKB/Swiss-Prot
    O75551, P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285363
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  22. XM_047431502.1XP_047287458.1  protein phosphatase 1A isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    54452043..54505381
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)