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PPM1A protein phosphatase, Mg2+/Mn2+ dependent 1A [ Homo sapiens (human) ]

Gene ID: 5494, updated on 9-Dec-2018

Summary

Official Symbol
PPM1Aprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1Aprovided by HGNC
Primary source
HGNC:HGNC:9275
See related
Ensembl:ENSG00000100614 MIM:606108
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP2CA; PP2Calpha; PP2C-ALPHA
Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 10.2), brain (RPKM 9.4) and 25 other tissues See more
Orthologs

Genomic context

See PPM1A in Genome Data Viewer
Location:
14q23.1
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (60245752..60299087)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (60712470..60765805)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 2 Neighboring gene uncharacterized LOC101927702 Neighboring gene long intergenic non-protein coding RNA 2322 Neighboring gene GNRHR2 pseudogene 1 Neighboring gene RNA binding motif protein 8B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein phosphatase, Mg2+/Mn2+ dependent, 1A (PPM1A) by siRNA ehnahces HIV-1 gene expression in resting CD4+ T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • BMP receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    BMP receptor signaling, organism-specific biosystem
    BMP receptor signaling
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystem (from REACTOME)
    Downregulation of SMAD2/3:SMAD4 transcriptional activity, organism-specific biosystemTranscriptional activity of SMAD2/3:SMAD4 heterotrimer can be inhibited by formation of a complex with SKI or SKIL (SNO), where SKI or SKIL recruit NCOR and possibly other transcriptional repressors ...
  • Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem (from REACTOME)
    Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystemUpon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. This phosphorylation is immediately removed in basal conditions by PP2C, but if the cellular AMP:ATP rati...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
    IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
  • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
    IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
  • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
    IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
  • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
    Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • PI3K Cascade, organism-specific biosystem (from REACTOME)
    PI3K Cascade, organism-specific biosystem
    PI3K Cascade
  • PKB-mediated events, organism-specific biosystem (from REACTOME)
    PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
  • Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling, organism-specific biosystem
    Regulation of cytoplasmic and nuclear SMAD2/3 signaling
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by TGF-beta Receptor Complex, organism-specific biosystem (from REACTOME)
    Signaling by TGF-beta Receptor Complex, organism-specific biosystemThe TGF-beta/BMP pathway incorporates several signaling pathways that share most, but not all, components of a central signal transduction engine. The general signaling scheme is rather simple: upon ...
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
  • Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystem (from REACTOME)
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer, organism-specific biosystemIn the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcrip...
  • mTOR signalling, organism-specific biosystem (from REACTOME)
    mTOR signalling, organism-specific biosystemTarget of rapamycin (mTOR) is a highly-conserved serine/threonine kinase that regulates cell growth and division in response to energy levels, growth signals, and nutrients (Zoncu et al. 2011). Contr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9201, FLJ42306

Gene Ontology Provided by GOA

Function Evidence Code Pubs
R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
calmodulin-dependent protein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
magnesium-dependent protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
manganese ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine phosphatase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
N-terminal protein myristoylation ISS
Inferred from Sequence or Structural Similarity
more info
 
cell cycle arrest TAS
Traceable Author Statement
more info
 
cellular response to transforming growth factor beta stimulus IEA
Inferred from Electronic Annotation
more info
 
dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of NIK/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of SMAD protein complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein export from nucleus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein phosphatase 1A
Names
protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
NP_066283.1
NP_808820.1
NP_808821.2
XP_005267836.1
XP_005267838.1
XP_011535174.1
XP_011535178.1
XP_011535179.1
XP_011535180.1
XP_011535181.1
XP_011535182.1
XP_011535183.1
XP_011535184.1
XP_011535185.1
XP_016876870.1
XP_016876871.1
XP_016876872.1
XP_016876873.1
XP_016876874.1
XP_016876875.1
XP_016876876.1
XP_024305405.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029698.1 RefSeqGene

    Range
    5001..58336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021003.5NP_066283.1  protein phosphatase 1A isoform 1

    See identical proteins and their annotated locations for NP_066283.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes isoform 1.
    Source sequence(s)
    AI076736, AL132778, AL157756, BC063243, DA439296
    Consensus CDS
    CCDS9744.1
    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Related
    ENSP00000378514.4, ENST00000395076.8
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  2. NM_177951.2NP_808820.1  protein phosphatase 1A isoform 2

    See identical proteins and their annotated locations for NP_808820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon within the 5' UTR and lacks a few of 3' exons but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AF070670, AL157756, CB156710, DA439296
    Consensus CDS
    CCDS9745.1
    UniProtKB/Swiss-Prot
    P35813
    Related
    ENSP00000314850.3, ENST00000325658.3
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285317
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  3. NM_177952.2NP_808821.2  protein phosphatase 1A isoform 3

    See identical proteins and their annotated locations for NP_808821.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon, as compared to variant 1. It encodes isoform 3, which has a distinct and longer N-terminus, as compared to isoform 1.
    Source sequence(s)
    AI076736, AK097843, AK313337, AL132778, BC063243
    Consensus CDS
    CCDS45120.1
    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    B2R8E4
    Related
    ENSP00000327255.3, ENST00000325642.7
    Conserved Domains (2) summary
    cd00143
    Location:96364
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:358433
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    60245752..60299087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267779.1XP_005267836.1  protein phosphatase 1A isoform X4

    See identical proteins and their annotated locations for XP_005267836.1

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  2. XM_005267781.1XP_005267838.1  protein phosphatase 1A isoform X4

    See identical proteins and their annotated locations for XP_005267838.1

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  3. XM_017021383.1XP_016876872.1  protein phosphatase 1A isoform X3

  4. XM_017021382.1XP_016876871.1  protein phosphatase 1A isoform X2

    Conserved Domains (2) summary
    cd00143
    Location:77345
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:339414
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  5. XM_011536877.1XP_011535179.1  protein phosphatase 1A isoform X2

    See identical proteins and their annotated locations for XP_011535179.1

    Conserved Domains (2) summary
    cd00143
    Location:77345
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:339414
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  6. XM_017021387.1XP_016876876.1  protein phosphatase 1A isoform X4

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  7. XM_024449637.1XP_024305405.1  protein phosphatase 1A isoform X4

    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  8. XM_017021381.1XP_016876870.1  protein phosphatase 1A isoform X1

    Conserved Domains (2) summary
    cd00143
    Location:100368
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:362437
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  9. XM_011536872.1XP_011535174.1  protein phosphatase 1A isoform X2

    See identical proteins and their annotated locations for XP_011535174.1

    Conserved Domains (2) summary
    cd00143
    Location:77345
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:339414
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  10. XM_011536876.1XP_011535178.1  protein phosphatase 1A isoform X2

    See identical proteins and their annotated locations for XP_011535178.1

    Conserved Domains (2) summary
    cd00143
    Location:77345
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:339414
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  11. XM_017021385.1XP_016876874.1  protein phosphatase 1A isoform X4

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  12. XM_011536878.1XP_011535180.1  protein phosphatase 1A isoform X4

    See identical proteins and their annotated locations for XP_011535180.1

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  13. XM_011536883.1XP_011535185.1  protein phosphatase 1A isoform X4

    See identical proteins and their annotated locations for XP_011535185.1

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  14. XM_017021386.1XP_016876875.1  protein phosphatase 1A isoform X4

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  15. XM_017021384.1XP_016876873.1  protein phosphatase 1A isoform X4

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  16. XM_011536880.3XP_011535182.1  protein phosphatase 1A isoform X4

    See identical proteins and their annotated locations for XP_011535182.1

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  17. XM_011536879.3XP_011535181.1  protein phosphatase 1A isoform X4

    See identical proteins and their annotated locations for XP_011535181.1

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  18. XM_011536881.3XP_011535183.1  protein phosphatase 1A isoform X4

    See identical proteins and their annotated locations for XP_011535183.1

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
  19. XM_011536882.2XP_011535184.1  protein phosphatase 1A isoform X4

    See identical proteins and their annotated locations for XP_011535184.1

    UniProtKB/Swiss-Prot
    P35813
    UniProtKB/TrEMBL
    A0A024R6A5
    Conserved Domains (2) summary
    cd00143
    Location:23291
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
    pfam07830
    Location:285360
    PP2C_C; Protein serine/threonine phosphatase 2C, C-terminal domain
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