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COMMD4 COMM domain containing 4 [ Homo sapiens (human) ]

Gene ID: 54939, updated on 24-Nov-2020

Summary

Official Symbol
COMMD4provided by HGNC
Official Full Name
COMM domain containing 4provided by HGNC
Primary source
HGNC:HGNC:26027
See related
Ensembl:ENSG00000140365 MIM:616701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in testis (RPKM 15.5), adrenal (RPKM 11.9) and 25 other tissues See more
Orthologs

Genomic context

See COMMD4 in Genome Data Viewer
Location:
15q24.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (75336035..75343227)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75628352..75634268)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene dynamin 1 pseudogene 34 Neighboring gene acidic nuclear phosphoprotein 32 family member B pseudogene 1 Neighboring gene nei like DNA glycosylase 1 Neighboring gene microRNA 631 Neighboring gene mannosidase alpha class 2C member 1 Neighboring gene Sharpr-MPRA regulatory region 58

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
COMM domain-containing protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284377.2NP_001271306.1  COMM domain-containing protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001271306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK000459
    Consensus CDS
    CCDS66834.1
    UniProtKB/Swiss-Prot
    Q9H0A8
    Related
    ENSP00000340867.6, ENST00000338995.10
    Conserved Domains (1) summary
    cl06336
    Location:25127
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  2. NM_001284378.2NP_001271307.1  COMM domain-containing protein 4 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AW117823, BI829264
    Consensus CDS
    CCDS66835.1
    UniProtKB/Swiss-Prot
    Q9H0A8
    Related
    ENSP00000457693.1, ENST00000567195.5
    Conserved Domains (1) summary
    cl06336
    Location:25101
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  3. NM_001284379.2NP_001271308.1  COMM domain-containing protein 4 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, contains multiple differences in the coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC068338, AW117823, BQ233598, DB524201, HY162014
    Consensus CDS
    CCDS73764.1
    UniProtKB/TrEMBL
    H3BQF2
    Related
    ENSP00000455750.1, ENST00000562789.5
    Conserved Domains (1) summary
    cl06336
    Location:31133
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  4. NM_001321844.2NP_001308773.1  COMM domain-containing protein 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC068338
    Conserved Domains (1) summary
    cd04752
    Location:1174
    Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  5. NM_001321845.2NP_001308774.1  COMM domain-containing protein 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC068338
    Conserved Domains (1) summary
    cl06336
    Location:2152
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  6. NM_001321846.2NP_001308775.1  COMM domain-containing protein 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC068338
    Conserved Domains (1) summary
    cl06336
    Location:26105
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  7. NM_001321847.2NP_001308776.1  COMM domain-containing protein 4 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC068338
    Consensus CDS
    CCDS81909.1
    UniProtKB/TrEMBL
    A0A0B4J287
    Related
    ENSP00000455249.1, ENST00000564815.5
    Conserved Domains (1) summary
    cl06336
    Location:26176
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  8. NM_001321848.2NP_001308777.1  COMM domain-containing protein 4 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC068338
    Conserved Domains (1) summary
    cd04752
    Location:31204
    Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  9. NM_017828.5NP_060298.2  COMM domain-containing protein 4 isoform 1

    See identical proteins and their annotated locations for NP_060298.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    BC068998, BI829484
    Consensus CDS
    CCDS10277.1
    UniProtKB/Swiss-Prot
    Q9H0A8
    Related
    ENSP00000267935.8, ENST00000267935.13
    Conserved Domains (1) summary
    cd04752
    Location:25198
    Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...

RNA

  1. NR_104312.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC068338, AL136872, BI829484
  2. NR_104313.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AW117823, BU540913, DB524201
    Related
    ENST00000562610.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    75336035..75343227
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449968.1XP_024305736.1  COMM domain-containing protein 4 isoform X1

    Conserved Domains (1) summary
    cd04752
    Location:25251
    Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  2. XM_011521739.2XP_011520041.1  COMM domain-containing protein 4 isoform X2

    Conserved Domains (1) summary
    cd04752
    Location:55228
    Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  3. XM_011521741.2XP_011520043.1  COMM domain-containing protein 4 isoform X6

    Conserved Domains (1) summary
    cl06336
    Location:55157
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  4. XM_011521740.1XP_011520042.1  COMM domain-containing protein 4 isoform X4

    Conserved Domains (1) summary
    cl06336
    Location:56206
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
  5. XM_017022385.1XP_016877874.1  COMM domain-containing protein 4 isoform X7

  6. XM_005254509.3XP_005254566.1  COMM domain-containing protein 4 isoform X3

    Related
    ENSP00000454283.1, ENST00000568301.1
    Conserved Domains (1) summary
    cd04752
    Location:52225
    Commd4; COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...
  7. XM_005254510.3XP_005254567.1  COMM domain-containing protein 4 isoform X5

    Conserved Domains (1) summary
    cl06336
    Location:53203
    Commd; COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in ...
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