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DUSP23 dual specificity phosphatase 23 [ Homo sapiens (human) ]

Gene ID: 54935, updated on 11-Jun-2021

Summary

Official Symbol
DUSP23provided by HGNC
Official Full Name
dual specificity phosphatase 23provided by HGNC
Primary source
HGNC:HGNC:21480
See related
Ensembl:ENSG00000158716 MIM:618361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VHZ; LDP3; MOSP; LDP-3; DUSP25
Expression
Ubiquitous expression in kidney (RPKM 18.6), liver (RPKM 13.3) and 25 other tissues See more
Orthologs
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Genomic context

See DUSP23 in Genome Data Viewer
Location:
1q23.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (159780962..159782543)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159750752..159752333)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27 pseudogene 2 Neighboring gene uncharacterized LOC101928264 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9322 Neighboring gene uncharacterized LOC105371464 Neighboring gene Fc receptor like 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
GeneReviews: Not available
Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ20442

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
dual specificity protein phosphatase 23
Names
VH1-like member Z
VH1-like phosphatase Z
low-molecular-mass dual-specificity phosphatase 3
testicular tissue protein Li 59
NP_001306587.1
NP_001306588.1
NP_060293.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001319658.2NP_001306587.1  dual specificity protein phosphatase 23

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AB164404, AL590560, BG823348, DA428735
    Consensus CDS
    CCDS1187.1
    UniProtKB/Swiss-Prot
    Q9BVJ7
    UniProtKB/TrEMBL
    A0A140VJI5
    Related
    ENSP00000357087.1, ENST00000368107.2
    Conserved Domains (1) summary
    cd14504
    Location:8148
    DUSP23; dual specificity phosphatase 23
  2. NM_001319659.2NP_001306588.1  dual specificity protein phosphatase 23

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BQ679163
    Consensus CDS
    CCDS1187.1
    UniProtKB/Swiss-Prot
    Q9BVJ7
    UniProtKB/TrEMBL
    A0A140VJI5
    Related
    ENSP00000357089.1, ENST00000368109.5
    Conserved Domains (1) summary
    cd14504
    Location:8148
    DUSP23; dual specificity phosphatase 23
  3. NM_017823.5NP_060293.2  dual specificity protein phosphatase 23

    See identical proteins and their annotated locations for NP_060293.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC001140, BQ679163
    Consensus CDS
    CCDS1187.1
    UniProtKB/Swiss-Prot
    Q9BVJ7
    UniProtKB/TrEMBL
    A0A140VJI5
    Related
    ENSP00000357088.3, ENST00000368108.7
    Conserved Domains (1) summary
    cd14504
    Location:8148
    DUSP23; dual specificity phosphatase 23

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    159780962..159782543
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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