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TRMT10C tRNA methyltransferase 10C, mitochondrial RNase P subunit [ Homo sapiens (human) ]

Gene ID: 54931, updated on 5-Sep-2021

Summary

Official Symbol
TRMT10Cprovided by HGNC
Official Full Name
tRNA methyltransferase 10C, mitochondrial RNase P subunitprovided by HGNC
Primary source
HGNC:HGNC:26022
See related
Ensembl:ENSG00000174173 MIM:615423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNYA; MRPP1; COXPD30; RG9MTD1
Summary
This gene encodes the precursor of a subunit of the mitochondrial ribonuclease P, which is involved in 5' processing of mitochondrial tRNAs. The encoded protein may confer RNA-binding capacity to mitochondrial ribonuclease P and may be essential for transcript processing, RNA modification, translation and mitochondrial respiration. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in adrenal (RPKM 10.2), lymph node (RPKM 9.9) and 25 other tissues See more
Orthologs
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Genomic context

See TRMT10C in Genome Data Viewer
Location:
3q12.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (101561868..101566446)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101280712..101285290)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 172 member B, pseudogene Neighboring gene CRISPRi-validated cis-regulatory element chr3.3097 Neighboring gene ribosomal protein S18 pseudogene 5 Neighboring gene PEST proteolytic signal containing nuclear protein Neighboring gene ribosomal protein L32 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20432, FLJ22879

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in mitochondrial matrix TAS
Traceable Author Statement
more info
 
located_in mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial ribonuclease P complex TAS
Traceable Author Statement
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tRNA methyltransferase 10 homolog C
Names
HBV pre-S2 trans-regulated protein 2
RNA (guanine-9-) methyltransferase domain containing 1
mRNA methyladenosine-N(1)-methyltransferase
mitochondrial RNase P subunit 1
mitochondrial ribonuclease P protein 1
renal carcinoma antigen NY-REN-49
tRNA (adenine(9)-N(1))-methyltransferase
tRNA (guanine(9)-N(1))-methyltransferase
NP_060289.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050898.1 RefSeqGene

    Range
    5033..9611
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017819.4NP_060289.2  tRNA methyltransferase 10 homolog C precursor

    See identical proteins and their annotated locations for NP_060289.2

    Status: REVIEWED

    Source sequence(s)
    BC035967, BU619586
    Consensus CDS
    CCDS43122.1
    UniProtKB/Swiss-Prot
    Q7L0Y3
    Related
    ENSP00000312356.6, ENST00000309922.7
    Conserved Domains (1) summary
    cl00407
    Location:213380
    tRNA_m1G_MT; tRNA (Guanine-1)-methyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    101561868..101566446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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