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HAUS4 HAUS augmin like complex subunit 4 [ Homo sapiens (human) ]

Gene ID: 54930, updated on 21-Dec-2019

Summary

Official Symbol
HAUS4provided by HGNC
Official Full Name
HAUS augmin like complex subunit 4provided by HGNC
Primary source
HGNC:HGNC:20163
See related
Ensembl:ENSG00000092036 MIM:613431
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C14orf94
Summary
This gene encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in ovary (RPKM 23.6), bone marrow (RPKM 22.4) and 25 other tissues See more
Orthologs

Genomic context

See HAUS4 in Genome Data Viewer
Location:
14q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (22946228..22957142, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23415437..23426352, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene PRMT5 antisense RNA 1 Neighboring gene protein arginine methyltransferase 5 Neighboring gene uncharacterized LOC101926933 Neighboring gene tRNA-Arg (anticodon ACG) 1-3 Neighboring gene microRNA 4707 Neighboring gene Sharpr-MPRA regulatory region 809 Neighboring gene ajuba LIM protein Neighboring gene uncharacterized LOC107984660 Neighboring gene chromosome 14 open reading frame 93

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20424, FLJ40661

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule minus-end binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
ciliary basal body-plasma membrane docking TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
HAUS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
HAUS complex IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
spindle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
HAUS augmin-like complex subunit 4
Names
homologous to Augmin subunits

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166269.1NP_001159741.1  HAUS augmin-like complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_001159741.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK000431, BC001916, BQ066232
    Consensus CDS
    CCDS9580.1
    UniProtKB/Swiss-Prot
    Q9H6D7
    Related
    ENSP00000441026.1, ENST00000541587.5
    Conserved Domains (1) summary
    pfam14735
    Location:127360
    HAUS4; HAUS augmin-like complex subunit 4
  2. NM_001166270.2NP_001159742.1  HAUS augmin-like complex subunit 4 isoform 2

    See identical proteins and their annotated locations for NP_001159742.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK000431, BX248256
    Consensus CDS
    CCDS53886.1
    UniProtKB/Swiss-Prot
    Q9H6D7
    Related
    ENSP00000342776.8, ENST00000342454.12
    Conserved Domains (1) summary
    pfam14735
    Location:109315
    HAUS4; HAUS augmin-like complex subunit 4
  3. NM_017815.3NP_060285.2  HAUS augmin-like complex subunit 4 isoform 1

    See identical proteins and their annotated locations for NP_060285.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK000431, AL132780
    Consensus CDS
    CCDS9580.1
    UniProtKB/Swiss-Prot
    Q9H6D7
    Related
    ENSP00000206474.7, ENST00000206474.11
    Conserved Domains (1) summary
    pfam14735
    Location:127360
    HAUS4; HAUS augmin-like complex subunit 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    22946228..22957142 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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