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YTHDF1 YTH N6-methyladenosine RNA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 54915, updated on 28-Nov-2021

Summary

Official Symbol
YTHDF1provided by HGNC
Official Full Name
YTH N6-methyladenosine RNA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:15867
See related
Ensembl:ENSG00000149658 MIM:616529
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DF1; C20orf21
Expression
Ubiquitous expression in thyroid (RPKM 18.6), bone marrow (RPKM 15.2) and 25 other tissues See more
Orthologs
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Genomic context

See YTHDF1 in Genome Data Viewer
Location:
20q13.33
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (63195429..63216131, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (61826781..61847483, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376996 Neighboring gene microRNA 124-3 Neighboring gene Sharpr-MPRA regulatory region 12386 Neighboring gene microRNA 3196 Neighboring gene baculoviral IAP repeat containing 7 Neighboring gene sodium/potassium transporting ATPase interacting 4 Neighboring gene uncharacterized LOC100192386

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20391

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N6-methyladenosine-containing RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N6-methyladenosine-containing RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in learning ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mRNA destabilization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in memory ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in organelle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in positive regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of antigen processing and presentation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mRNA stability IDA
Inferred from Direct Assay
more info
PubMed 
involved_in stress granule assembly IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
YTH domain-containing family protein 1
Names
DACA-1
YTH N(6)-methyladenosine RNA binding protein 1
YTH domain family 1
YTH domain family protein 1
YTH domain family, member 1
dermatomyositis associated with cancer putative autoantigen 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017798.4NP_060268.2  YTH domain-containing family protein 1

    See identical proteins and their annotated locations for NP_060268.2

    Status: VALIDATED

    Source sequence(s)
    BC003681, BC050284
    Consensus CDS
    CCDS13511.1
    UniProtKB/Swiss-Prot
    Q9BYJ9
    Related
    ENSP00000359364.3, ENST00000370339.8
    Conserved Domains (3) summary
    pfam04146
    Location:390523
    YTH; YT521-B-like domain
    cl09930
    Location:258311
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    cl26464
    Location:227364
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    63195429..63216131 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451914.1XP_024307682.1  YTH domain-containing family protein 1 isoform X1

    Conserved Domains (3) summary
    pfam04146
    Location:340473
    YTH; YT521-B-like domain
    cl09930
    Location:208261
    RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    cl26464
    Location:177314
    Atrophin-1; Atrophin-1 family
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