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RPP25 ribonuclease P and MRP subunit p25 [ Homo sapiens (human) ]

Gene ID: 54913, updated on 5-Mar-2024

Summary

Official Symbol
RPP25provided by HGNC
Official Full Name
ribonuclease P and MRP subunit p25provided by HGNC
Primary source
HGNC:HGNC:30361
See related
Ensembl:ENSG00000178718 MIM:619235; AllianceGenome:HGNC:30361
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables ribonuclease P RNA binding activity. Contributes to ribonuclease P activity. Involved in tRNA 5'-leader removal. Located in centriolar satellite and nucleoplasm. Part of multimeric ribonuclease P complex and ribonuclease MRP complex. Biomarker of autistic disorder. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See RPP25 in Genome Data Viewer
Location:
15q24.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (74954418..74956772, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (72824301..72826655, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75246759..75249113, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75191053-75191552 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75197802-75198608 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75198609-75199413 Neighboring gene family with sequence similarity 219 member B Neighboring gene mannose phosphate isomerase Neighboring gene cytochrome c oxidase subunit 5A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9819 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75246929-75247862 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75247863-75248796 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75248797-75249730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75250725-75251281 Neighboring gene secretory carrier membrane protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9820 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75323765-75324265 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:75326220-75326413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75328766-75329266 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:75329616-75329854 Neighboring gene phosphopantothenoylcysteine decarboxylase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9821 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:75335422-75336621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6663

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ20374

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribonuclease P RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to ribonuclease P activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in tRNA 5'-leader removal IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
 
part_of multimeric ribonuclease P complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonuclease MRP complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ribonuclease P protein subunit p25
Names
RNase P protein subunit p25
ribonuclease P 25kDa subunit
ribonuclease P/MRP 25kDa subunit
ribonuclease P/MRP subunit p25
NP_060263.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017793.3NP_060263.2  ribonuclease P protein subunit p25

    See identical proteins and their annotated locations for NP_060263.2

    Status: VALIDATED

    Source sequence(s)
    AC015720
    Consensus CDS
    CCDS10274.1
    UniProtKB/Swiss-Prot
    D3DW70, Q9BUL9, Q9NX88
    Related
    ENSP00000317691.6, ENST00000322177.6
    Conserved Domains (1) summary
    pfam01918
    Location:37101
    Alba

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    74954418..74956772 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    72824301..72826655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)