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SEMA4C semaphorin 4C [ Homo sapiens (human) ]

Gene ID: 54910, updated on 23-Nov-2021

Summary

Official Symbol
SEMA4Cprovided by HGNC
Official Full Name
semaphorin 4Cprovided by HGNC
Primary source
HGNC:HGNC:10731
See related
Ensembl:ENSG00000168758 MIM:604462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEMAF; SEMAI; SEMACL1; M-SEMA-F
Expression
Ubiquitous expression in placenta (RPKM 20.2), endometrium (RPKM 13.1) and 24 other tissues See more
Orthologs
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Genomic context

See SEMA4C in Genome Data Viewer
Location:
2q11.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96859718..96870943, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97525455..97535817, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 23 Neighboring gene ankyrin repeat domain 39 Neighboring gene family with sequence similarity 178 member B Neighboring gene Sharpr-MPRA regulatory region 12522 Neighboring gene uncharacterized LOC101927053

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20369, KIAA1739, MGC126382, MGC126383

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration in hindbrain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
 
involved_in muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in semaphorin-plexin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
semaphorin-4C
Names
M-Sema F
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017789.5NP_060259.4  semaphorin-4C precursor

    See identical proteins and their annotated locations for NP_060259.4

    Status: VALIDATED

    Source sequence(s)
    AC092636, BC017476, BC109104, BI518922
    Consensus CDS
    CCDS2029.1
    UniProtKB/Swiss-Prot
    Q9C0C4
    Related
    ENSP00000306844.5, ENST00000305476.10
    Conserved Domains (3) summary
    cd11258
    Location:42498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560647
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96859718..96870943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511380.1XP_011509682.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509682.1

    UniProtKB/Swiss-Prot
    Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560647
    Ig; Immunoglobulin domain
  2. XM_011511381.1XP_011509683.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509683.1

    UniProtKB/Swiss-Prot
    Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560647
    Ig; Immunoglobulin domain
  3. XM_011511379.2XP_011509681.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509681.1

    UniProtKB/Swiss-Prot
    Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560647
    Ig; Immunoglobulin domain
  4. XM_011511378.2XP_011509680.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509680.1

    UniProtKB/Swiss-Prot
    Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560647
    Ig; Immunoglobulin domain
  5. XM_011511383.1XP_011509685.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509685.1

    UniProtKB/Swiss-Prot
    Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560647
    Ig; Immunoglobulin domain
  6. XM_011511382.3XP_011509684.1  semaphorin-4C isoform X1

    See identical proteins and their annotated locations for XP_011509684.1

    UniProtKB/Swiss-Prot
    Q9C0C4
    Conserved Domains (3) summary
    cd11258
    Location:42498
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
    smart00423
    Location:499528
    PSI; domain found in Plexins, Semaphorins and Integrins
    cl11960
    Location:560647
    Ig; Immunoglobulin domain
  7. XM_017004393.2XP_016859882.1  semaphorin-4C isoform X2

  8. XM_017004394.2XP_016859883.1  semaphorin-4C isoform X4

    Related
    ENST00000482925.5
  9. XM_006712606.3XP_006712669.2  semaphorin-4C isoform X3

    Conserved Domains (1) summary
    cd11258
    Location:42480
    Sema_4C; The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C)
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