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CYP2W1 cytochrome P450 family 2 subfamily W member 1 [ Homo sapiens (human) ]

Gene ID: 54905, updated on 23-Nov-2021

Summary

Official Symbol
CYP2W1provided by HGNC
Official Full Name
cytochrome P450 family 2 subfamily W member 1provided by HGNC
Primary source
HGNC:HGNC:20243
See related
Ensembl:ENSG00000073067 MIM:615967
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 2.9), duodenum (RPKM 2.7) and 8 other tissues See more
Orthologs
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Genomic context

See CYP2W1 in Genome Data Viewer
Location:
7p22.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (983155..989640)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1022817..1029276)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ArfGAP with dual PH domains 1 Neighboring gene Sharpr-MPRA regulatory region 8554 Neighboring gene cytochrome c oxidase assembly factor COX19 Neighboring gene chromosome 7 open reading frame 50 Neighboring gene nonconserved acetylation island sequence 100 enhancer Neighboring gene microRNA 339

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC34287

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in aflatoxin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in organic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phospholipid metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in retinoic acid catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome P450 2W1
Names
CYPIIW1
cytochrome P450, family 2, subfamily W, polypeptide 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007934.1 RefSeqGene

    Range
    4983..11442
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017781.3NP_060251.2  cytochrome P450 2W1 precursor

    See identical proteins and their annotated locations for NP_060251.2

    Status: REVIEWED

    Source sequence(s)
    AC073957, BC025761
    Consensus CDS
    CCDS5319.2
    UniProtKB/Swiss-Prot
    Q8TAV3
    Related
    ENSP00000310149.7, ENST00000308919.12
    Conserved Domains (1) summary
    pfam00067
    Location:32479
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    983155..989640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515441.3XP_011513743.1  cytochrome P450 2W1 isoform X2

    Conserved Domains (1) summary
    pfam00067
    Location:32462
    p450; Cytochrome P450
  2. XM_011515440.3XP_011513742.1  cytochrome P450 2W1 isoform X1

    Conserved Domains (1) summary
    pfam00067
    Location:32452
    p450; Cytochrome P450
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