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NCAPG2 non-SMC condensin II complex subunit G2 [ Homo sapiens (human) ]

Gene ID: 54892, updated on 8-Jul-2021

Summary

Official Symbol
NCAPG2provided by HGNC
Official Full Name
non-SMC condensin II complex subunit G2provided by HGNC
Primary source
HGNC:HGNC:21904
See related
Ensembl:ENSG00000146918 MIM:608532
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
3KS; MTB; CAPG2; LUZP5; CAP-G2; hCAP-G2
Summary
This gene encodes a protein that belongs to the Condensin2nSMC family of proteins. The encoded protein is a regulatory subunit of the condensin II complex which, along with the condensin I complex, plays a role in chromosome assembly and segregation during mitosis. A similar protein in mouse is required for early development of the embryo. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Broad expression in testis (RPKM 7.7), bone marrow (RPKM 6.8) and 24 other tissues See more
Orthologs
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Genomic context

See NCAPG2 in Genome Data Viewer
Location:
7q36.3
Exon count:
33
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (158631169..158704816, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (158423861..158497495, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1022 Neighboring gene microRNA 5707 Neighboring gene THAP domain containing 5 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 76 Neighboring gene extended synaptotagmin 2 Neighboring gene putative uncharacterized protein FLJ46204

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ20311

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables bHLH transcription factor binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme activator activity IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase regulator activity IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription regulator inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in chromosome condensation IEA
Inferred from Electronic Annotation
more info
 
involved_in erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in inner cell mass cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic sister chromatid segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of histone deacetylation IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of condensin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane HDA PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
condensin-2 complex subunit G2
Names
chromosome-associated protein G2
leucine zipper protein 5
more than blood homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047159.1 RefSeqGene

    Range
    5028..78663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001281932.2NP_001268861.1  condensin-2 complex subunit G2 isoform a

    See identical proteins and their annotated locations for NP_001268861.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform a).
    Source sequence(s)
    AC019084, AC093662, AK092008, DB069860, DW419642
    Consensus CDS
    CCDS43686.1
    UniProtKB/Swiss-Prot
    Q86XI2
    UniProtKB/TrEMBL
    B3KRQ2
    Related
    ENSP00000386569.1, ENST00000409423.5
    Conserved Domains (2) summary
    pfam12422
    Location:213361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368405
    HEAT; HEAT repeat [structural motif]
  2. NM_001281933.2NP_001268862.1  condensin-2 complex subunit G2 isoform b

    See identical proteins and their annotated locations for NP_001268862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 3' terminal exon which results in a frameshift. The encoded isoform (b) has a distinct C-terminus and is longer than isoform a.
    Source sequence(s)
    AC019084, BX537845, DB069860
    Consensus CDS
    CCDS64816.1
    UniProtKB/Swiss-Prot
    Q86XI2
    Related
    ENSP00000387007.3, ENST00000409339.3
    Conserved Domains (2) summary
    pfam12422
    Location:213361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368405
    HEAT; HEAT repeat [structural motif]
  3. NM_017760.7NP_060230.5  condensin-2 complex subunit G2 isoform a

    See identical proteins and their annotated locations for NP_060230.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a). Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC093662, BC043404, DB069860, DW419642
    Consensus CDS
    CCDS43686.1
    UniProtKB/Swiss-Prot
    Q86XI2
    Related
    ENSP00000348657.3, ENST00000356309.8
    Conserved Domains (2) summary
    pfam12422
    Location:213361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368405
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_104054.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains three alternate exons and uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC093662, BC028618, DB069860, DW419642
    Related
    ENST00000432615.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    158631169..158704816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249547.3XP_005249604.1  condensin-2 complex subunit G2 isoform X4

    See identical proteins and their annotated locations for XP_005249604.1

    Related
    ENSP00000408080.1, ENST00000441982.5
    Conserved Domains (2) summary
    pfam12422
    Location:213361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368405
    HEAT; HEAT repeat [structural motif]
  2. XM_017012374.2XP_016867863.1  condensin-2 complex subunit G2 isoform X2

    Conserved Domains (2) summary
    pfam12422
    Location:213361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368405
    HEAT; HEAT repeat [structural motif]
  3. XM_011516362.1XP_011514664.1  condensin-2 complex subunit G2 isoform X9

  4. XM_017012376.2XP_016867865.1  condensin-2 complex subunit G2 isoform X5

  5. XM_017012375.2XP_016867864.1  condensin-2 complex subunit G2 isoform X3

  6. XM_011516356.3XP_011514658.1  condensin-2 complex subunit G2 isoform X1

    See identical proteins and their annotated locations for XP_011514658.1

    UniProtKB/Swiss-Prot
    Q86XI2
    Conserved Domains (2) summary
    pfam12422
    Location:213361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368405
    HEAT; HEAT repeat [structural motif]
  7. XM_011516357.2XP_011514659.1  condensin-2 complex subunit G2 isoform X1

    See identical proteins and their annotated locations for XP_011514659.1

    UniProtKB/Swiss-Prot
    Q86XI2
    Conserved Domains (2) summary
    pfam12422
    Location:213361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368405
    HEAT; HEAT repeat [structural motif]
  8. XM_017012377.1XP_016867866.1  condensin-2 complex subunit G2 isoform X7

  9. XM_017012378.1XP_016867867.1  condensin-2 complex subunit G2 isoform X8

    Related
    ENST00000467785.5
  10. XM_011516358.3XP_011514660.1  condensin-2 complex subunit G2 isoform X6

    Conserved Domains (2) summary
    pfam12422
    Location:213361
    Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
    sd00044
    Location:368405
    HEAT; HEAT repeat [structural motif]
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