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PLPPR1 phospholipid phosphatase related 1 [ Homo sapiens (human) ]

Gene ID: 54886, updated on 22-Sep-2022

Summary

Official Symbol
PLPPR1provided by HGNC
Official Full Name
phospholipid phosphatase related 1provided by HGNC
Primary source
HGNC:HGNC:25993
See related
Ensembl:ENSG00000148123 MIM:619590; AllianceGenome:HGNC:25993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRG3; LPPR1; PRG-3
Summary
This gene encodes a member of the plasticity-related gene (PRG) family. Members of the PRG family mediate lipid phosphate phosphatase activity in neurons and are known to be involved in neuronal plasticity. The protein encoded by this gene does not perform its function through enzymatic phospholipid degradation. This gene is strongly expressed in brain. It shows dynamic expression regulation during brain development and neuronal excitation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 18.9), kidney (RPKM 12.9) and 2 other tissues See more
Orthologs
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Genomic context

See PLPPR1 in Genome Data Viewer
Location:
9q31.1
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (101028727..101325135)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (113200691..113497101)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (103791009..104087417)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376181 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 26 Neighboring gene Sharpr-MPRA regulatory region 7573 Neighboring gene TRPC6 pseudogene 4 Neighboring gene uncharacterized LOC105376183 Neighboring gene uncharacterized LOC105376182 Neighboring gene Sharpr-MPRA regulatory region 15176 Neighboring gene uncharacterized LOC124902238 Neighboring gene acyl-CoA:amino acid N-acyltransferase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26189

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables lysophosphatidic acid phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT involved_in phospholipid dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
phospholipid phosphatase-related protein type 1
Names
inactive 2-lysophosphatidate phosphatase PLPPR1
lipid phosphate phosphatase-related protein type 1
plasticity related gene 3
plasticity-related gene 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017753.3NP_060223.2  phospholipid phosphatase-related protein type 1

    See identical proteins and their annotated locations for NP_060223.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternative exon at the 5' end compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AL161631, AL359893
    Consensus CDS
    CCDS6751.1
    UniProtKB/Swiss-Prot
    Q8TBJ4, Q9NXE2
    UniProtKB/TrEMBL
    A0A024R154
    Related
    ENSP00000378496.1, ENST00000395056.2
    Conserved Domains (1) summary
    cd03384
    Location:123272
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
  2. NM_207299.2NP_997182.1  phospholipid phosphatase-related protein type 1

    See identical proteins and their annotated locations for NP_997182.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
    Source sequence(s)
    AK000307, AL357935, BC022465, BI601921, BI914341
    Consensus CDS
    CCDS6751.1
    UniProtKB/Swiss-Prot
    Q8TBJ4, Q9NXE2
    UniProtKB/TrEMBL
    A0A024R154
    Related
    ENSP00000364008.3, ENST00000374874.8
    Conserved Domains (1) summary
    cd03384
    Location:123272
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    101028727..101325135
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187578.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    79930..376338
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    113200691..113497101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)