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ST7L suppression of tumorigenicity 7 like [ Homo sapiens (human) ]

Gene ID: 54879, updated on 1-Jun-2020

Summary

Official Symbol
ST7Lprovided by HGNC
Official Full Name
suppression of tumorigenicity 7 likeprovided by HGNC
Primary source
HGNC:HGNC:18441
See related
Ensembl:ENSG00000007341 MIM:617640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST7R; STLR; FAM4B
Summary
This gene was identified by its similarity to the ST7 tumor suppressor gene found in the chromosome 7q31 region. This gene is clustered in a tail-to-tail manner with the WNT2B gene in a chromosomal region known to be deleted and rearranged in a variety of cancers. Several transcript variants encoding many different isoforms have been described, but some have not been fully characterized. [provided by RefSeq, Feb 2011]
Expression
Broad expression in testis (RPKM 6.6), skin (RPKM 3.2) and 24 other tissues See more
Orthologs

Genomic context

See ST7L in Genome Data Viewer
Location:
1p13.2
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (112517444..112619881, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (113066140..113162040, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CTTNBP2 N-terminal like Neighboring gene microRNA 4256 Neighboring gene Wnt family member 2B Neighboring gene mitochondrial ribosomal protein L53 pseudogene 1 Neighboring gene capping actin protein of muscle Z-line subunit alpha 1 Neighboring gene RNA, U7 small nuclear 70 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11657, FLJ20284

Gene Ontology Provided by GOA

Process Evidence Code Pubs
negative regulation of cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
suppressor of tumorigenicity 7 protein-like
Names
ST7-related protein
tumor suppressor ST7 like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308264.2NP_001295193.1  suppressor of tumorigenicity 7 protein-like isoform 7

    See identical proteins and their annotated locations for NP_001295193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) contains an alternate 5' terminal exon and lacks an alternate exon in its 5' UTR. This variant represents translation initiation at a downstream start codon compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream start codon to encode an isoform (7) that has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB081317, AK097837, AL109932, AL929470, BC047392, BX537988, BX538338
    Consensus CDS
    CCDS76189.1
    UniProtKB/Swiss-Prot
    Q8TDW4
    Related
    ENSP00000358683.1, ENST00000369669.5
    Conserved Domains (1) summary
    cd11557
    Location:1355
    ST7; Suppression of tumorigenicity 7
  2. NM_017744.5NP_060214.2  suppressor of tumorigenicity 7 protein-like isoform 1

    See identical proteins and their annotated locations for NP_060214.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB081317, AL109932, BX538338
    Consensus CDS
    CCDS848.1
    UniProtKB/Swiss-Prot
    Q8TDW4
    Related
    ENSP00000350734.4, ENST00000358039.9
    Conserved Domains (1) summary
    pfam04184
    Location:43552
    ST7; ST7 protein
  3. NM_138727.4NP_620055.1  suppressor of tumorigenicity 7 protein-like isoform 2

    See identical proteins and their annotated locations for NP_620055.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in an isoform (2) that is missing an internal region, as compared to isoform 1.
    Source sequence(s)
    AB081318, AL109932, BX538338
    Consensus CDS
    CCDS849.1
    UniProtKB/Swiss-Prot
    Q8TDW4
    Related
    ENSP00000417140.1, ENST00000490067.5
    Conserved Domains (1) summary
    cd11557
    Location:69521
    ST7; Suppression of tumorigenicity 7
  4. NM_138728.3NP_620056.1  suppressor of tumorigenicity 7 protein-like isoform 3

    See identical proteins and their annotated locations for NP_620056.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment, compared to variant 1, resulting in an isoform (3) that is missing an internal region, as compared to isoform 1.
    Source sequence(s)
    AB081319, AL109932, BX538338
    Consensus CDS
    CCDS850.1
    UniProtKB/Swiss-Prot
    Q8TDW4
    Related
    ENSP00000353972.4, ENST00000360743.8
    Conserved Domains (1) summary
    cd11557
    Location:72507
    ST7; Suppression of tumorigenicity 7
  5. NM_138729.3NP_620057.1  suppressor of tumorigenicity 7 protein-like isoform 4

    See identical proteins and their annotated locations for NP_620057.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR, when compared to variant 1, resulting in an isoform (4) that has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AB081320, BC027898, CD358134
    Consensus CDS
    CCDS852.1
    UniProtKB/Swiss-Prot
    Q8TDW4
    Related
    ENSP00000345312.7, ENST00000343210.11
    Conserved Domains (1) summary
    cd11557
    Location:72538
    ST7; Suppression of tumorigenicity 7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    112517444..112619881 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541628.2XP_011539930.1  suppressor of tumorigenicity 7 protein-like isoform X2

    Conserved Domains (1) summary
    cd11557
    Location:72538
    ST7; Suppression of tumorigenicity 7
  2. XM_017001536.1XP_016857025.1  suppressor of tumorigenicity 7 protein-like isoform X7

  3. XM_011541631.3XP_011539933.1  suppressor of tumorigenicity 7 protein-like isoform X5

    See identical proteins and their annotated locations for XP_011539933.1

    Conserved Domains (1) summary
    cd11557
    Location:12416
    ST7; Suppression of tumorigenicity 7
  4. XM_005270964.3XP_005271021.1  suppressor of tumorigenicity 7 protein-like isoform X5

    See identical proteins and their annotated locations for XP_005271021.1

    Conserved Domains (1) summary
    cd11557
    Location:12416
    ST7; Suppression of tumorigenicity 7
  5. XM_024447771.1XP_024303539.1  suppressor of tumorigenicity 7 protein-like isoform X8

    Conserved Domains (1) summary
    cl19051
    Location:2254
    ST7; Suppression of tumorigenicity 7
  6. XM_005270963.4XP_005271020.1  suppressor of tumorigenicity 7 protein-like isoform X5

    See identical proteins and their annotated locations for XP_005271020.1

    Conserved Domains (1) summary
    cd11557
    Location:12416
    ST7; Suppression of tumorigenicity 7
  7. XM_011541629.2XP_011539931.1  suppressor of tumorigenicity 7 protein-like isoform X4

    Conserved Domains (1) summary
    cd11557
    Location:16482
    ST7; Suppression of tumorigenicity 7
  8. XM_011541627.2XP_011539929.1  suppressor of tumorigenicity 7 protein-like isoform X1

    Conserved Domains (1) summary
    cd11557
    Location:72538
    ST7; Suppression of tumorigenicity 7
  9. XM_017001534.1XP_016857023.1  suppressor of tumorigenicity 7 protein-like isoform X3

  10. XM_017001535.1XP_016857024.1  suppressor of tumorigenicity 7 protein-like isoform X6

RNA

  1. XR_946674.2 RNA Sequence

  2. XR_001737249.1 RNA Sequence

  3. XR_001737251.1 RNA Sequence

  4. XR_001737252.1 RNA Sequence

  5. XR_246280.4 RNA Sequence

  6. XR_946675.2 RNA Sequence

  7. XR_001737250.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198327.1: Suppressed sequence

    Description
    NM_198327.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and the protein also lacks homolog support.
  2. NM_198328.1: Suppressed sequence

    Description
    NM_198328.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and the protein also lacks homolog support.
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