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DPP8 dipeptidyl peptidase 8 [ Homo sapiens (human) ]

Gene ID: 54878, updated on 10-Oct-2020

Summary

Official Symbol
DPP8provided by HGNC
Official Full Name
dipeptidyl peptidase 8provided by HGNC
Primary source
HGNC:HGNC:16490
See related
Ensembl:ENSG00000074603 MIM:606819
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP8; DPRP1; DPRP-1; MST097; MSTP097; MSTP135; MSTP141
Summary
This gene encodes a member of the peptidase S9B family, a small family of dipeptidyl peptidases that are able to cleave peptide substrates at a prolyl bond. The encoded protein shares similarity with dipeptidyl peptidase IV in that it is ubiquitously expressed, and hydrolyzes the same substrates. These similarities suggest that, like dipeptidyl peptidase IV, this protein may play a role in T-cell activation and immune function. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 9.5), testis (RPKM 9.3) and 25 other tissues See more
Orthologs

Genomic context

See DPP8 in Genome Data Viewer
Location:
15q22.31
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (65442467..65517689, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65734805..65810040, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily DCC subclass member 3 Neighboring gene immunoglobulin superfamily DCC subclass member 4 Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene RNA, U6 small nuclear 19, pseudogene Neighboring gene integrator complex subunit 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14920, FLJ20283, MGC26191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptidyl-peptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
dipeptidyl peptidase 8
Names
DPP VIII
dipeptidyl peptidase IV-related protein 1
dipeptidyl peptidase VIII
prolyl dipeptidase DPP8
NP_001307804.1
NP_001307805.1
NP_060213.2
NP_569118.1
NP_932064.1
NP_932065.1
XP_005254562.1
XP_011520032.1
XP_011520033.1
XP_011520034.1
XP_011520035.1
XP_011520036.1
XP_016877863.1
XP_016877864.1
XP_016877865.1
XP_016877866.1
XP_016877867.1
XP_016877868.1
XP_016877869.1
XP_016877870.1
XP_016877871.1
XP_016877872.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320875.2NP_001307804.1  dipeptidyl peptidase 8 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and 5' coding region which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus compared to isoform 1. Both variants 3 and 6 encode the same isoform (3).
    Source sequence(s)
    AC011846, AC105129, AK291057, BU753778
    Consensus CDS
    CCDS10207.1
    UniProtKB/Swiss-Prot
    Q6V1X1
    UniProtKB/TrEMBL
    A0A024R5Z6, A8K4U2
    Conserved Domains (2) summary
    pfam00326
    Location:686891
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175594
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  2. NM_001320876.2NP_001307805.1  dipeptidyl peptidase 8 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Both variants 1 and 8 encode the same isoform (1).
    Source sequence(s)
    AC011846, AC105129, AK296915, BU753778
    Consensus CDS
    CCDS10210.1
    UniProtKB/Swiss-Prot
    Q6V1X1
    UniProtKB/TrEMBL
    B4DLA8
    Conserved Domains (2) summary
    pfam00326
    Location:670875
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:159578
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  3. NM_017743.6NP_060213.2  dipeptidyl peptidase 8 isoform 2

    See identical proteins and their annotated locations for NP_060213.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two exons in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC105129, AK000290, BU753778, DC412877
    Consensus CDS
    CCDS10209.1
    UniProtKB/Swiss-Prot
    Q6V1X1
    Related
    ENSP00000351817.4, ENST00000358939.8
    Conserved Domains (2) summary
    pfam00930
    Location:159579
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:657775
    Abhydrolase; alpha/beta hydrolases
  4. NM_130434.5NP_569118.1  dipeptidyl peptidase 8 isoform 1

    See identical proteins and their annotated locations for NP_569118.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Both variants 1 and 8 encode the same isoform (1).
    Source sequence(s)
    AC011846, AC105129, AF221634, BU753778
    Consensus CDS
    CCDS10210.1
    UniProtKB/Swiss-Prot
    Q6V1X1
    Related
    ENSP00000300141.6, ENST00000300141.11
    Conserved Domains (2) summary
    pfam00326
    Location:670875
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:159578
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  5. NM_197960.4NP_932064.1  dipeptidyl peptidase 8 isoform 3

    See identical proteins and their annotated locations for NP_932064.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region which results in the use of an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has a distinct N-terminus compared to isoform 1. Both variants 3 and 6 encode the same isoform (3).
    Source sequence(s)
    AC011846, AC105129, AY354202, BU753778
    Consensus CDS
    CCDS10207.1
    UniProtKB/Swiss-Prot
    Q6V1X1
    UniProtKB/TrEMBL
    A0A024R5Z6
    Related
    ENSP00000339208.5, ENST00000341861.9
    Conserved Domains (2) summary
    pfam00326
    Location:686891
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175594
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  6. NM_197961.4NP_932065.1  dipeptidyl peptidase 8 isoform 4

    See identical proteins and their annotated locations for NP_932065.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR and 5' coding region and lacks an exon in the 3' coding region compared to variant 1. These diferences result in the use of an alternate start codon compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC105129, BC030688, BU753778
    Consensus CDS
    CCDS10208.1
    UniProtKB/Swiss-Prot
    Q6V1X1
    Related
    ENSP00000318111.6, ENST00000321147.10
    Conserved Domains (2) summary
    pfam00930
    Location:175594
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:686840
    Abhydrolase; alpha/beta hydrolases

RNA

  1. NR_135485.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate exon in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011846, AC105129, BU753778, DC412877
  2. NR_135486.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate 5' exon structure and uses an alternate exon in the 3' region compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC011846, AC105129, AK302638, BU753778

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    65442467..65517689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022381.2XP_016877870.1  dipeptidyl peptidase 8 isoform X13

  2. XM_017022377.2XP_016877866.1  dipeptidyl peptidase 8 isoform X9

  3. XM_017022379.2XP_016877868.1  dipeptidyl peptidase 8 isoform X11

  4. XM_011521733.2XP_011520035.1  dipeptidyl peptidase 8 isoform X7

    Conserved Domains (3) summary
    COG1073
    Location:563814
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    pfam00326
    Location:612817
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:126521
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  5. XM_017022375.2XP_016877864.1  dipeptidyl peptidase 8 isoform X4

  6. XM_017022376.2XP_016877865.1  dipeptidyl peptidase 8 isoform X5

    Conserved Domains (2) summary
    pfam00930
    Location:159579
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:670824
    Abhydrolase; alpha/beta hydrolases
  7. XM_011521731.2XP_011520033.1  dipeptidyl peptidase 8 isoform X3

    Conserved Domains (3) summary
    COG1073
    Location:579830
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    pfam00326
    Location:628833
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:142537
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  8. XM_011521730.2XP_011520032.1  dipeptidyl peptidase 8 isoform X1

    See identical proteins and their annotated locations for XP_011520032.1

    Conserved Domains (3) summary
    COG1073
    Location:594845
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    pfam00326
    Location:643848
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175552
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  9. XM_011521734.2XP_011520036.1  dipeptidyl peptidase 8 isoform X8

    See identical proteins and their annotated locations for XP_011520036.1

    Conserved Domains (3) summary
    COG1506
    Location:549791
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00930
    Location:175595
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:673791
    Abhydrolase; alpha/beta hydrolases
  10. XM_017022378.2XP_016877867.1  dipeptidyl peptidase 8 isoform X10

    Related
    ENSP00000379013.3, ENST00000395652.7
  11. XM_017022374.2XP_016877863.1  dipeptidyl peptidase 8 isoform X2

    UniProtKB/Swiss-Prot
    Q6V1X1
    Conserved Domains (2) summary
    pfam00930
    Location:175594
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    cl21494
    Location:686840
    Abhydrolase; alpha/beta hydrolases
  12. XM_011521732.3XP_011520034.1  dipeptidyl peptidase 8 isoform X6

    Conserved Domains (3) summary
    COG1506
    Location:549807
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:686806
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:175595
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
  13. XM_017022383.1XP_016877872.1  dipeptidyl peptidase 8 isoform X14

  14. XM_017022382.1XP_016877871.1  dipeptidyl peptidase 8 isoform X14

  15. XM_005254505.1XP_005254562.1  dipeptidyl peptidase 8 isoform X15

    Conserved Domains (2) summary
    COG1073
    Location:218469
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    pfam00326
    Location:267472
    Peptidase_S9; Prolyl oligopeptidase family
  16. XM_017022380.2XP_016877869.1  dipeptidyl peptidase 8 isoform X12

RNA

  1. XR_001751337.2 RNA Sequence

  2. XR_001751335.2 RNA Sequence

  3. XR_001751338.2 RNA Sequence

  4. XR_001751334.2 RNA Sequence

  5. XR_001751333.2 RNA Sequence

  6. XR_001751336.2 RNA Sequence

  7. XR_001751339.2 RNA Sequence

  8. XR_001751340.2 RNA Sequence

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