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ZCCHC2 zinc finger CCHC-type containing 2 [ Homo sapiens (human) ]

Gene ID: 54877, updated on 5-Sep-2021

Summary

Official Symbol
ZCCHC2provided by HGNC
Official Full Name
zinc finger CCHC-type containing 2provided by HGNC
Primary source
HGNC:HGNC:22916
See related
Ensembl:ENSG00000141664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C18orf49
Expression
Ubiquitous expression in testis (RPKM 5.7), salivary gland (RPKM 5.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZCCHC2 in Genome Data Viewer
Location:
18q21.33
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (62523025..62587709)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (60190258..60253962)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L17 pseudogene 44 Neighboring gene ACTB pseudogene 9 Neighboring gene RNA, 7SL, cytoplasmic 705, pseudogene Neighboring gene RNA, U6 small nuclear 142, pseudogene Neighboring gene PH domain and leucine rich repeat protein phosphatase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20222, FLJ20281, KIAA1744, MGC13269, DKFZp451A185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger CCHC domain-containing protein 2
Names
zinc finger, CCHC domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017742.6NP_060212.4  zinc finger CCHC domain-containing protein 2

    See identical proteins and their annotated locations for NP_060212.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AA903206, AB051531, AC064801, AK000288, BC006340, BQ001246, BU675299, DN997998, FN169762
    Consensus CDS
    CCDS45880.1
    UniProtKB/Swiss-Prot
    Q9C0B9
    UniProtKB/TrEMBL
    Q9BRD4
    Related
    ENSP00000269499.4, ENST00000269499.10
    Conserved Domains (2) summary
    pfam00098
    Location:11331148
    zf-CCHC; Zinc knuckle
    cl02563
    Location:363461
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RNA

  1. NR_126534.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' exon structure, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA406111, AC064801, AL832323, BC137435, DN997998

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    62523025..62587709
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025802.2XP_016881291.1  zinc finger CCHC domain-containing protein 2 isoform X2

  2. XM_006722493.3XP_006722556.1  zinc finger CCHC domain-containing protein 2 isoform X1

    Conserved Domains (2) summary
    pfam00098
    Location:10551070
    zf-CCHC; Zinc knuckle
    cl02563
    Location:283381
    PX_domain; The Phox Homology domain, a phosphoinositide binding module
  3. XM_011526044.1XP_011524346.1  zinc finger CCHC domain-containing protein 2 isoform X3

    Related
    ENSP00000464791.1, ENST00000586834.1
    Conserved Domains (2) summary
    pfam00098
    Location:839854
    zf-CCHC; Zinc knuckle
    cl02563
    Location:67165
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RNA

  1. XR_001753205.1 RNA Sequence

  2. XR_245462.2 RNA Sequence

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