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DCAF16 DDB1 and CUL4 associated factor 16 [ Homo sapiens (human) ]

Gene ID: 54876, updated on 8-Jul-2021

Summary

Official Symbol
DCAF16provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 16provided by HGNC
Primary source
HGNC:HGNC:25987
See related
Ensembl:ENSG00000163257
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C4orf30
Expression
Ubiquitous expression in ovary (RPKM 5.2), endometrium (RPKM 5.1) and 25 other tissues See more
Orthologs
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Genomic context

See DCAF16 in Genome Data Viewer
Location:
4p15.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (17793446..17810757, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (17795069..17812380, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene leucine aminopeptidase 3 Neighboring gene mediator complex subunit 28 Neighboring gene family with sequence similarity 184 member B Neighboring gene non-SMC condensin I complex subunit G Neighboring gene ligand dependent nuclear receptor corepressor like Neighboring gene keratin 18 pseudogene 63

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with DDB1 and CUL4 associated factor 16 (DCAF16) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20280, MGC126765, MGC126767

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001345880.2NP_001332809.1  DDB1- and CUL4-associated factor 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-6 all encode the same protein.
    Source sequence(s)
    AC005768
    Consensus CDS
    CCDS3423.1
    UniProtKB/Swiss-Prot
    Q9NXF7
    Conserved Domains (1) summary
    pfam15349
    Location:1216
    DCA16; DDB1- and CUL4-associated factor 16
  2. NM_001345881.2NP_001332810.1  DDB1- and CUL4-associated factor 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) plus variants 1-2 and 4-6 all encode the same protein.
    Source sequence(s)
    AC005768
    Consensus CDS
    CCDS3423.1
    UniProtKB/Swiss-Prot
    Q9NXF7
    Conserved Domains (1) summary
    pfam15349
    Location:1216
    DCA16; DDB1- and CUL4-associated factor 16
  3. NM_001345882.2NP_001332811.1  DDB1- and CUL4-associated factor 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) plus variants 1-3 and 5-6 all encode the same protein.
    Source sequence(s)
    AC005768
    Consensus CDS
    CCDS3423.1
    UniProtKB/Swiss-Prot
    Q9NXF7
    Conserved Domains (1) summary
    pfam15349
    Location:1216
    DCA16; DDB1- and CUL4-associated factor 16
  4. NM_001345884.2NP_001332813.1  DDB1- and CUL4-associated factor 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) plus variants 1-4 and 6 all encode the same protein.
    Source sequence(s)
    AC005768
    Consensus CDS
    CCDS3423.1
    UniProtKB/Swiss-Prot
    Q9NXF7
    Conserved Domains (1) summary
    pfam15349
    Location:1216
    DCA16; DDB1- and CUL4-associated factor 16
  5. NM_001345885.2NP_001332814.1  DDB1- and CUL4-associated factor 16

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) plus variants 1-5 all encode the same protein.
    Source sequence(s)
    AC005768
    Consensus CDS
    CCDS3423.1
    UniProtKB/Swiss-Prot
    Q9NXF7
    Conserved Domains (1) summary
    pfam15349
    Location:1216
    DCA16; DDB1- and CUL4-associated factor 16
  6. NM_017741.4NP_060211.3  DDB1- and CUL4-associated factor 16

    See identical proteins and their annotated locations for NP_060211.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) plus variants 1 and 3-6 all encode the same protein.
    Source sequence(s)
    AC005768
    Consensus CDS
    CCDS3423.1
    UniProtKB/Swiss-Prot
    Q9NXF7
    Related
    ENSP00000371682.1, ENST00000382247.6
    Conserved Domains (1) summary
    pfam15349
    Location:1216
    DCA16; DDB1- and CUL4-associated factor 16

RNA

  1. NR_144301.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005768
  2. NR_144303.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005768
  3. NR_144305.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005768
  4. NR_144310.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC005768

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    17793446..17810757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024454104.1XP_024309872.1  DDB1- and CUL4-associated factor 16 isoform X1

    Conserved Domains (1) summary
    pfam15349
    Location:1216
    DCA16; DDB1- and CUL4-associated factor 16

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_144299.1: Suppressed sequence

    Description
    NR_144299.1: This RefSeq was removed because there is insufficient support for the transcript.
  2. NR_144300.1: Suppressed sequence

    Description
    NR_144300.1: This RefSeq was removed because there is insufficient support for the transcript.
  3. NR_144302.1: Suppressed sequence

    Description
    NR_144302.1: This RefSeq was removed because there is insufficient support for the transcript.
  4. NR_144304.1: Suppressed sequence

    Description
    NR_144304.1: This RefSeq was removed because there is insufficient support for the transcript.
  5. NR_144306.1: Suppressed sequence

    Description
    NR_144306.1: This RefSeq was removed because there is insufficient support for the transcript.
  6. NR_144307.1: Suppressed sequence

    Description
    NR_144307.1: This RefSeq was removed because there is insufficient support for the transcript.
  7. NR_144308.1: Suppressed sequence

    Description
    NR_144308.1: This RefSeq was removed because there is insufficient support for the transcript.
  8. NR_144309.1: Suppressed sequence

    Description
    NR_144309.1: This RefSeq was removed because there is insufficient support for the transcript.
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