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FNBP1L formin binding protein 1 like [ Homo sapiens (human) ]

Gene ID: 54874, updated on 1-Jun-2020

Summary

Official Symbol
FNBP1Lprovided by HGNC
Official Full Name
formin binding protein 1 likeprovided by HGNC
Primary source
HGNC:HGNC:20851
See related
Ensembl:ENSG00000137942 MIM:608848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TOCA1; C1orf39
Summary
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 14.8), kidney (RPKM 13.9) and 24 other tissues See more
Orthologs

Genomic context

See FNBP1L in Genome Data Viewer
Location:
1p22.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (93448067..93569671)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (93913688..94020218)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene F-box and WD repeat domain containing 11 pseudogene Neighboring gene down-regulator of transcription 1 Neighboring gene RNA, 5S ribosomal pseudogene 53 Neighboring gene tRNA-Cys (anticodon GCA) 7-1 Neighboring gene BCAR3 adaptor protein, NSP family member Neighboring gene BCAR3 antisense RNA 1 Neighboring gene uncharacterized LOC102723480

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding HDA PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
autophagy IEA
Inferred from Electronic Annotation
more info
 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
clathrin-dependent endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
membrane invagination IDA
Inferred from Direct Assay
more info
PubMed 
membrane organization TAS
Traceable Author Statement
more info
 
plasma membrane tubulation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
vesicle budding from membrane IDA
Inferred from Direct Assay
more info
PubMed 
vesicle organization IDA
Inferred from Direct Assay
more info
PubMed 
vesicle transport along actin filament IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
cell cortex IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
formin-binding protein 1-like
Names
toca-1
transducer of Cdc42-dependent actin assembly 1
transducer of Cdc42-dependent actin assembly protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024948.2NP_001020119.1  formin-binding protein 1-like isoform 1

    See identical proteins and their annotated locations for NP_001020119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two alternate in-frame exons and differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (1) is shorter and has a distinct C-terminus compared to isoform 3.
    Source sequence(s)
    AK000282, AK025526, AY514449, BC062477, DB219295, DW423801
    Consensus CDS
    CCDS53344.1
    UniProtKB/Swiss-Prot
    Q5T0N5
    Related
    ENSP00000260506.8, ENST00000260506.12
    Conserved Domains (3) summary
    cd07675
    Location:5256
    F-BAR_FNBP1L; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
    cd11628
    Location:341421
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd12072
    Location:483539
    SH3_FNBP1L; Src Homology 3 domain of Formin Binding Protein 1-Like
  2. NM_001164473.2NP_001157945.1  formin-binding protein 1-like isoform 3

    See identical proteins and their annotated locations for NP_001157945.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (3).
    Source sequence(s)
    AK000282, AK299760, AY514449, DW423801
    Consensus CDS
    CCDS53343.1
    UniProtKB/Swiss-Prot
    Q5T0N5
    UniProtKB/TrEMBL
    B4DSI7
    Related
    ENSP00000271234.7, ENST00000271234.11
    Conserved Domains (3) summary
    cd07675
    Location:5256
    F-BAR_FNBP1L; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
    cd11628
    Location:399479
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd12072
    Location:541597
    SH3_FNBP1L; Src Homology 3 domain of Formin Binding Protein 1-Like
  3. NM_017737.5NP_060207.2  formin-binding protein 1-like isoform 2

    See identical proteins and their annotated locations for NP_060207.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 3.
    Source sequence(s)
    AC095034, AK000282, AY514449, DW423801
    Consensus CDS
    CCDS60192.1
    UniProtKB/Swiss-Prot
    Q5T0N5
    Related
    ENSP00000359275.2, ENST00000370253.6
    Conserved Domains (3) summary
    cd07675
    Location:5256
    F-BAR_FNBP1L; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
    cd11628
    Location:341421
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd12072
    Location:483539
    SH3_FNBP1L; Src Homology 3 domain of Formin Binding Protein 1-Like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    93448067..93569671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541625.2XP_011539927.1  formin-binding protein 1-like isoform X1

    Conserved Domains (3) summary
    cd07675
    Location:5256
    F-BAR_FNBP1L; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Formin Binding Protein 1-Like
    cd11628
    Location:341421
    HR1_CIP4_FNBP1L; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of vertebrate Cdc42-Interacting Protein 4 and FormiN Binding Protein 1-Like
    cd12072
    Location:483539
    SH3_FNBP1L; Src Homology 3 domain of Formin Binding Protein 1-Like
  2. XM_017001533.1XP_016857022.1  formin-binding protein 1-like isoform X2

RNA

  1. XR_001737248.1 RNA Sequence

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