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TMEM104 transmembrane protein 104 [ Homo sapiens (human) ]

Gene ID: 54868, updated on 22-Sep-2022

Summary

Official Symbol
TMEM104provided by HGNC
Official Full Name
transmembrane protein 104provided by HGNC
Primary source
HGNC:HGNC:25984
See related
Ensembl:ENSG00000109066 AllianceGenome:HGNC:25984
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 2.7), thyroid (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See TMEM104 in Genome Data Viewer
Location:
17q25.1
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74776499..74839753)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75668389..75731527)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72772638..72835892)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene microRNA 3615 Neighboring gene NHERF family PDZ scaffold protein 1 Neighboring gene N-acetyltransferase 9 (putative) Neighboring gene glutamate ionotropic receptor NMDA type subunit 2C Neighboring gene ferredoxin reductase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00021, FLJ20255

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321264.3NP_001308193.1  transmembrane protein 104 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK000262, CN479614, DN999695
    Consensus CDS
    CCDS82201.1
    UniProtKB/Swiss-Prot
    Q8NE00
    Related
    ENSP00000463205.1, ENST00000582773.5
  2. NM_017728.4NP_060198.3  transmembrane protein 104 isoform 1

    See identical proteins and their annotated locations for NP_060198.3

    Status: VALIDATED

    Source sequence(s)
    AC068874, AK074029, CN479614, DN999695
    Consensus CDS
    CCDS32723.1
    UniProtKB/Swiss-Prot
    Q8NE00, Q9NXH1
    UniProtKB/TrEMBL
    A0A024R8L3
    Related
    ENSP00000334849.5, ENST00000335464.10
    Conserved Domains (1) summary
    cl00456
    Location:209443
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74776499..74839753
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721963.3XP_006722026.1  transmembrane protein 104 isoform X1

    Conserved Domains (1) summary
    cl00456
    Location:208442
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_047436329.1XP_047292285.1  transmembrane protein 104 isoform X4

  3. XM_017024799.3XP_016880288.1  transmembrane protein 104 isoform X5

  4. XM_017024798.3XP_016880287.1  transmembrane protein 104 isoform X3

  5. XM_017024797.2XP_016880286.1  transmembrane protein 104 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75668389..75731527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)