Format

Send to:

Choose Destination

TMEM214 transmembrane protein 214 [ Homo sapiens (human) ]

Gene ID: 54867, updated on 1-Jun-2020

Summary

Official Symbol
TMEM214provided by HGNC
Official Full Name
transmembrane protein 214provided by HGNC
Primary source
HGNC:HGNC:25983
See related
Ensembl:ENSG00000119777 MIM:615301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in placenta (RPKM 25.1), thyroid (RPKM 23.8) and 25 other tissues See more
Orthologs

Genomic context

See TMEM214 in Genome Data Viewer
Location:
2p23.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27032965..27041694)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27255774..27264565)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dihydropyrimidinase like 5 Neighboring gene microtubule associated protein RP/EB family member 3 Neighboring gene MAPRE3 antisense RNA 1 Neighboring gene tRNA-Tyr (anticodon GTA) 2-1 Neighboring gene AGBL5 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20254, FLJ39682

Gene Ontology Provided by GOA

Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083590.2NP_001077059.1  transmembrane protein 214 isoform 2

    See identical proteins and their annotated locations for NP_001077059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AA460659, AC013472, AK097308, CF994632
    Consensus CDS
    CCDS46242.1
    UniProtKB/Swiss-Prot
    Q6NUQ4
    Related
    ENSP00000384417.3, ENST00000404032.7
    Conserved Domains (1) summary
    pfam10151
    Location:172640
    DUF2359; uncharacterized conserved protein (DUF2359)
  2. NM_017727.5NP_060197.4  transmembrane protein 214 isoform 1

    See identical proteins and their annotated locations for NP_060197.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL833725, CF994632
    Consensus CDS
    CCDS42664.1
    UniProtKB/Swiss-Prot
    Q6NUQ4
    Related
    ENSP00000238788.9, ENST00000238788.14
    Conserved Domains (1) summary
    pfam10151
    Location:217685
    DUF2359; uncharacterized conserved protein (DUF2359)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27032965..27041694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264381.4XP_005264438.1  transmembrane protein 214 isoform X1

    Conserved Domains (1) summary
    pfam10151
    Location:217749
    DUF2359; uncharacterized conserved protein (DUF2359)
  2. XM_005264382.4XP_005264439.1  transmembrane protein 214 isoform X2

    Conserved Domains (1) summary
    pfam10151
    Location:217711
    DUF2359; uncharacterized conserved protein (DUF2359)
  3. XM_005264383.3XP_005264440.1  transmembrane protein 214 isoform X3

    Related
    ENSP00000392442.1, ENST00000444135.5
    Conserved Domains (1) summary
    pfam10151
    Location:47348
    DUF2359; uncharacterized conserved protein (DUF2359)

RNA

  1. XR_001738793.2 RNA Sequence

    Related
    ENST00000435172.6
  2. XR_426985.3 RNA Sequence

  3. XR_001738791.2 RNA Sequence

  4. XR_001738792.2 RNA Sequence

Support Center