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PPP1R14D protein phosphatase 1 regulatory inhibitor subunit 14D [ Homo sapiens (human) ]

Gene ID: 54866, updated on 18-Nov-2018

Summary

Official Symbol
PPP1R14Dprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 14Dprovided by HGNC
Primary source
HGNC:HGNC:14953
See related
Ensembl:ENSG00000166143 MIM:613256; Vega:OTTHUMG00000130064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GBPI1; GBPI-1; CPI17-like
Summary
Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010]
Expression
Biased expression in duodenum (RPKM 31.1), colon (RPKM 28.0) and 3 other tissues See more
Orthologs

Genomic context

See PPP1R14D in Genome Data Viewer
Location:
15q15.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (40815445..40828793, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41107643..41121283, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C17 Neighboring gene chromosome 15 open reading frame 62 Neighboring gene zinc finger FYVE-type containing 19 Neighboring gene SPINT1 antisense RNA 1 Neighboring gene serine peptidase inhibitor, Kunitz type 1 Neighboring gene ras homolog family member V

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein phosphatase 1, regulatory subunit 14D (PPP1R14D) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20251, MGC119014, MGC119016

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 14D
Names
PKC-dependent PP1 inhibitory protein
gastrointestinal and brain-specific PP1-inhibitory protein 1
gut and brain phosphatase inhibitor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130143.1NP_001123615.1  protein phosphatase 1 regulatory subunit 14D isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AI963626, BC098150
    Consensus CDS
    CCDS45230.1
    UniProtKB/TrEMBL
    E9PAT1, Q4V755
    Related
    ENSP00000398342.2, OTTHUMP00000249669, ENST00000427255.2, OTTHUMT00000421220
    Conserved Domains (2) summary
    pfam05361
    Location:2784
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor
    pfam13900
    Location:101123
    GVQW; Putative domain of unknown function
  2. NM_017726.7NP_060196.1  protein phosphatase 1 regulatory subunit 14D isoform 1

    See identical proteins and their annotated locations for NP_060196.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) lacks an exon in the coding region, compared to variant 2, resulting in a frameshift and a protein (isoform 1) with a truncated C-terminus, compared to isoform 2.
    Source sequence(s)
    AI963626, AY050671
    Consensus CDS
    CCDS10066.1
    UniProtKB/Swiss-Prot
    Q9NXH3
    Related
    ENSP00000299174.5, OTTHUMP00000160541, ENST00000299174.9, OTTHUMT00000252355
    Conserved Domains (1) summary
    pfam05361
    Location:27139
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    40815445..40828793 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022372.1XP_016877861.1  protein phosphatase 1 regulatory subunit 14D isoform X1

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