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GON4L gon-4 like [ Homo sapiens (human) ]

Gene ID: 54856, updated on 13-Mar-2020

Summary

Official Symbol
GON4Lprovided by HGNC
Official Full Name
gon-4 likeprovided by HGNC
Primary source
HGNC:HGNC:25973
See related
Ensembl:ENSG00000116580 MIM:610393
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GON4; YARP; GON-4
Expression
Ubiquitous expression in testis (RPKM 11.0), spleen (RPKM 8.9) and 25 other tissues See more
Orthologs

Genomic context

See GON4L in Genome Data Viewer
Location:
1q22
Exon count:
35
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (155749658..155859426, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155719450..155829185, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene YY1 associated protein 1 Neighboring gene death associated protein 3 Neighboring gene uncharacterized LOC100505728 Neighboring gene misato family member 2, pseudogene Neighboring gene small Cajal body-specific RNA 26B Neighboring gene proteasome 26S subunit, non-ATPase 7 pseudogene Neighboring gene synaptotagmin 11 Neighboring gene Ras like without CAAX 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12923, FLJ20203, FLJ23040, KIAA1606, MGC138817, MGC138818, DKFZp761I241, RP11-101O6.1, RP11-243J18.4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
GON-4-like protein
Names
2610100B20Rik
YY1AP related protein
YY1AP-related protein1
gon-4 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282856.1NP_001269785.1  GON-4-like protein isoform c

    See identical proteins and their annotated locations for NP_001269785.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 3. Variants 3 and 4 encode the same, longest protein (isoform c).
    Source sequence(s)
    AL162734, AY335491, CN391065
    Consensus CDS
    CCDS60296.1
    UniProtKB/Swiss-Prot
    Q3T8J9
    Related
    ENSP00000483100.1, ENST00000615926.4
    Conserved Domains (2) summary
    cd12202
    Location:21432208
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:16481693
    PAH; Paired amphipathic helix repeat
  2. NM_001282858.2NP_001269787.1  GON-4-like protein isoform a

    See identical proteins and their annotated locations for NP_001269787.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 3' coding region, compared to variant 3. This results in a shorter protein (isoform a), compared to isoform c.
    Source sequence(s)
    AB195687, AL162734, BC064933, BC114629, CN391065
    Consensus CDS
    CCDS44242.1
    UniProtKB/Swiss-Prot
    Q3T8J9
    UniProtKB/TrEMBL
    A4PB67
    Conserved Domains (2) summary
    cd12202
    Location:21422207
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:16481693
    PAH; Paired amphipathic helix repeat
  3. NM_001282860.2NP_001269789.1  GON-4-like protein isoform c

    See identical proteins and their annotated locations for NP_001269789.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longest protein. Variants 3 and 4 encode isoform (c).
    Source sequence(s)
    AL139128, AL162734
    Consensus CDS
    CCDS60296.1
    UniProtKB/Swiss-Prot
    Q3T8J9
    UniProtKB/TrEMBL
    A4PB67
    Related
    ENSP00000357315.1, ENST00000368331.5
    Conserved Domains (2) summary
    cd12202
    Location:21432208
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:16481693
    PAH; Paired amphipathic helix repeat
  4. NM_001282861.2NP_001269790.1  GON-4-like protein isoform b

    See identical proteins and their annotated locations for NP_001269790.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains a 3' terminal exon that extends past a splice site that is used in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AB195687, AI476308, AK022985, AL139128, BC036740, BC115703
    Consensus CDS
    CCDS1121.1
    UniProtKB/Swiss-Prot
    Q3T8J9
    UniProtKB/TrEMBL
    A4PB67, Q14BN2, Q9H986
    Related
    ENSP00000478593.1, ENST00000622608.1
    Conserved Domains (1) summary
    PHA03247
    Location:10071436
    PHA03247; large tegument protein UL36; Provisional
  5. NM_032292.6NP_115668.4  GON-4-like protein isoform b

    See identical proteins and their annotated locations for NP_115668.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains a 3' terminal exon that extends past a splice site in variant 3. This results in a novel 3' coding region and 3' UTR, compared to variant 3. It encodes isoform b which is shorter and has a distinct C-terminus, compared to isoform c.
    Source sequence(s)
    AB195688, AI476308, AL139128, BC036740, BC114629
    Consensus CDS
    CCDS1121.1
    UniProtKB/Swiss-Prot
    Q3T8J9
    UniProtKB/TrEMBL
    A4PB68
    Related
    ENSP00000354322.5, ENST00000361040.9
    Conserved Domains (1) summary
    PHA03247
    Location:10071436
    PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    155749658..155859426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711394.4XP_006711457.1  GON-4-like protein isoform X1

    See identical proteins and their annotated locations for XP_006711457.1

    UniProtKB/Swiss-Prot
    Q3T8J9
    Related
    ENSP00000396117.1, ENST00000437809.5
    Conserved Domains (2) summary
    cd12202
    Location:21422207
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:16481693
    PAH; Paired amphipathic helix repeat
  2. XM_006711393.3XP_006711456.1  GON-4-like protein isoform X1

    See identical proteins and their annotated locations for XP_006711456.1

    UniProtKB/Swiss-Prot
    Q3T8J9
    Related
    ENSP00000271883.5, ENST00000271883.9
    Conserved Domains (2) summary
    cd12202
    Location:21422207
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:16481693
    PAH; Paired amphipathic helix repeat
  3. XM_011509658.2XP_011507960.1  GON-4-like protein isoform X2

    Conserved Domains (2) summary
    cd12202
    Location:21132178
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:16191664
    PAH; Paired amphipathic helix repeat
  4. XM_005245284.3XP_005245341.1  GON-4-like protein isoform X3

    See identical proteins and their annotated locations for XP_005245341.1

    Conserved Domains (2) summary
    cd12202
    Location:19702035
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:14761521
    PAH; Paired amphipathic helix repeat
  5. XM_011509659.2XP_011507961.1  GON-4-like protein isoform X3

    See identical proteins and their annotated locations for XP_011507961.1

    Conserved Domains (2) summary
    cd12202
    Location:19702035
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:14761521
    PAH; Paired amphipathic helix repeat
  6. XM_005245286.3XP_005245343.1  GON-4-like protein isoform X4

    Conserved Domains (2) summary
    cd12202
    Location:13381403
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    pfam02671
    Location:844889
    PAH; Paired amphipathic helix repeat

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001037533.1: Suppressed sequence

    Description
    NM_001037533.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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