alox12b arachidonate 12-lipoxygenase, 12R type [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: alox12bprovided by Xenbase
Official Full Name: arachidonate 12-lipoxygenase, 12R typeprovided by Xenbase
Primary source: Xenbase:XB-GENE-5909078
See related: Ensembl:ENSXETG00000043131 AllianceGenome:Xenbase:XB-GENE-5909078
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: 12r-lox
Summary: Predicted to enable oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Predicted to be involved in arachidonate metabolic process; lipid oxidation; and lipoxygenase pathway. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1; autosomal recessive congenital ichthyosis 2; and autosomal recessive congenital ichthyosis 3. Orthologous to several human genes including ALOXE3 (arachidonate epidermal lipoxygenase 3). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	2	NC_030678.2 (179572427..179584136, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	Unplaced Scaffold	NW_016683580.1 (8093..30625, complement)

Chromosome 2 - NC_030678.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid oxidation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within lipid oxidation	IEA Inferred from Electronic Annotation more info
involved_in lipoxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arachidonate 12-lipoxygenase, 12R type

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001015741.1 → NP_001015741.1 arachidonate 12-lipoxygenase, 12R type

See identical proteins and their annotated locations for NP_001015741.1

Status: PROVISIONAL

Source sequence(s)

BC089676

UniProtKB/TrEMBL

A0A7D9NLV4, Q5FW07

Related

ENSXETP00000040476.5, ENSXETT00000040476.5

Conserved Domains (2) summary

cd01753
Location:2 → 115

PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...

cl27717
Location:226 → 653

Lipoxygenase; Lipoxygenase