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NUP62CL nucleoporin 62 C-terminal like [ Homo sapiens (human) ]

Gene ID: 54830, updated on 1-Jun-2020

Summary

Official Symbol
NUP62CLprovided by HGNC
Official Full Name
nucleoporin 62 C-terminal likeprovided by HGNC
Primary source
HGNC:HGNC:25960
See related
Ensembl:ENSG00000198088
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein containing a domain found in nucleoporins which are glycoproteins found in nuclear pore complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Expression
Broad expression in testis (RPKM 5.8), adrenal (RPKM 5.6) and 18 other tissues See more
Orthologs

Genomic context

See NUP62CL in Genome Data Viewer
Location:
Xq22.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (107123427..107206433, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (106366657..106449670, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 40 Neighboring gene RNA binding motif protein 41 Neighboring gene GTF3C6 pseudogene 2 Neighboring gene dynein axonemal assembly factor 6 Neighboring gene MYCL pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20130

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of nuclear pore IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear pore IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
nucleoporin-62 C-terminal-like protein
Names
nucleoporin 62kDa C-terminal like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021315.1 RefSeqGene

    Range
    5008..88014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017681.3NP_060151.2  nucleoporin-62 C-terminal-like protein

    See identical proteins and their annotated locations for NP_060151.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein.
    Source sequence(s)
    BC016327, BF805909, BX105515, DB448067
    Consensus CDS
    CCDS14527.1
    UniProtKB/Swiss-Prot
    Q9H1M0
    UniProtKB/TrEMBL
    A0A0S2Z5E8
    Related
    ENSP00000361544.4, ENST00000372466.8
    Conserved Domains (1) summary
    pfam05064
    Location:61173
    Nsp1_C; Nsp1-like C-terminal region

RNA

  1. NR_033676.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI702317, BC017799
    Related
    ENST00000484614.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    107123427..107206433 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024452393.1XP_024308161.1  nucleoporin-62 C-terminal-like protein isoform X1

    Conserved Domains (1) summary
    pfam05064
    Location:61173
    Nsp1_C; Nsp1-like C-terminal region
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