Format

Send to:

Choose Destination

ZCCHC10 zinc finger CCHC-type containing 10 [ Homo sapiens (human) ]

Gene ID: 54819, updated on 24-Nov-2020

Summary

Official Symbol
ZCCHC10provided by HGNC
Official Full Name
zinc finger CCHC-type containing 10provided by HGNC
Primary source
HGNC:HGNC:25954
See related
Ensembl:ENSG00000155329
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in lymph node (RPKM 8.3), testis (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See ZCCHC10 in Genome Data Viewer
Location:
5q31.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (132996985..133026621, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (132332677..132362275, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene AF4/FMR2 family member 4 Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 1 Neighboring gene small nuclear ribonucleoprotein U4/U6.U5 subunit 27 pseudogene Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene Neighboring gene heat shock protein family A (Hsp70) member 4 Neighboring gene uncharacterized LOC105379178

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20094

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger CCHC domain-containing protein 10
Names
zinc finger, CCHC domain containing 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300816.3NP_001287745.1  zinc finger CCHC domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_001287745.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK000101, AK300543, BC022443
    Consensus CDS
    CCDS75301.1
    UniProtKB/Swiss-Prot
    Q8TBK6
    UniProtKB/TrEMBL
    B4DU89
    Related
    ENSP00000423276.1, ENST00000509437.6
    Conserved Domains (1) summary
    pfam13917
    Location:3976
    zf-CCHC_3; Zinc knuckle
  2. NM_001300817.3NP_001287746.1  zinc finger CCHC domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001287746.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AK000101, AK122970, AK300543, BC022443
    Consensus CDS
    CCDS78060.1
    UniProtKB/Swiss-Prot
    Q8TBK6
    UniProtKB/TrEMBL
    B3KVL5, B4DU89
    Related
    ENSP00000347533.2, ENST00000355372.6
    Conserved Domains (1) summary
    pfam13917
    Location:3976
    zf-CCHC_3; Zinc knuckle
  3. NM_001300818.3NP_001287747.1  zinc finger CCHC domain-containing protein 10 isoform 3

    See identical proteins and their annotated locations for NP_001287747.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AK000101, AK300543, BC022443, BU165290
    UniProtKB/Swiss-Prot
    Q8TBK6
    UniProtKB/TrEMBL
    B4DU89
    Conserved Domains (1) summary
    pfam13917
    Location:3976
    zf-CCHC_3; Zinc knuckle
  4. NM_001300819.3NP_001287748.1  zinc finger CCHC domain-containing protein 10 isoform 5

    See identical proteins and their annotated locations for NP_001287748.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon in both the 5' and 3' coding regions, compared to variant 1, resulting in an isoform (5) that is shorter than isoform 1.
    Source sequence(s)
    AK000101, AK300543, BC022443
    Consensus CDS
    CCDS75300.1
    UniProtKB/Swiss-Prot
    Q8TBK6
    UniProtKB/TrEMBL
    B4DU89, G3XAM1
    Related
    ENSP00000427430.1, ENST00000513848.5
    Conserved Domains (1) summary
    pfam13917
    Location:1754
    zf-CCHC_3; Zinc knuckle
  5. NM_001300822.3NP_001287751.1  zinc finger CCHC domain-containing protein 10 isoform 6

    See identical proteins and their annotated locations for NP_001287751.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1, resulting in an isoform (6) that has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK000101, AK300543, BC022443, CB112418
    Consensus CDS
    CCDS75302.1
    UniProtKB/Swiss-Prot
    Q8TBK6
    UniProtKB/TrEMBL
    B4DU89, D6R9G7
    Related
    ENSP00000422111.1, ENST00000513541.5
    Conserved Domains (1) summary
    pfam13917
    Location:3976
    zf-CCHC_3; Zinc knuckle
  6. NM_001308127.2NP_001295056.1  zinc finger CCHC domain-containing protein 10 isoform 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (9) that is longer than isoform 1.
    Source sequence(s)
    AK000101, DA905071
    UniProtKB/Swiss-Prot
    Q8TBK6
    UniProtKB/TrEMBL
    B4DU89
    Conserved Domains (1) summary
    pfam13917
    Location:4988
    zf-CCHC_3; Zinc knuckle
  7. NM_001308128.2NP_001295057.1  zinc finger CCHC domain-containing protein 10 isoform 10

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) lacks two alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (10) that is shorter than isoform 1.
    Source sequence(s)
    AK000101, DA345717
    UniProtKB/Swiss-Prot
    Q8TBK6
  8. NM_001308129.2NP_001295058.1  zinc finger CCHC domain-containing protein 10 isoform 11

    See identical proteins and their annotated locations for NP_001295058.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) lacks three alternate in-frame exons in the central coding region, compared to variant 1, resulting in an isoform (11) that is shorter than isoform 1.
    Source sequence(s)
    AK000101, AK300543, BI766652
    UniProtKB/Swiss-Prot
    Q8TBK6
    UniProtKB/TrEMBL
    B4DU89
  9. NM_001308130.2NP_001295059.1  zinc finger CCHC domain-containing protein 10 isoform 12

    See identical proteins and their annotated locations for NP_001295059.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) lacks an alternate in-frame exon in the 5' coding region, and uses an alternate splice site that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (12) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK000101, AK300543, DA528172
    Consensus CDS
    CCDS78059.1
    UniProtKB/Swiss-Prot
    Q8TBK6
    UniProtKB/TrEMBL
    B4DU89, D6RHC2
    Related
    ENSP00000421071.1, ENST00000509008.1
    Conserved Domains (1) summary
    pfam13917
    Location:1754
    zf-CCHC_3; Zinc knuckle
  10. NM_017665.4NP_060135.1  zinc finger CCHC domain-containing protein 10 isoform 4

    See identical proteins and their annotated locations for NP_060135.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
    Source sequence(s)
    AK000101, AK300543
    Consensus CDS
    CCDS4165.1
    UniProtKB/Swiss-Prot
    Q8TBK6
    UniProtKB/TrEMBL
    B4DU89
    Related
    ENSP00000324274.3, ENST00000324170.7
    Conserved Domains (1) summary
    pfam13917
    Location:1754
    zf-CCHC_3; Zinc knuckle

RNA

  1. NR_125337.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the 5' terminal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK000101, AK300543, BM470321
  2. NR_131766.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 5' terminal exon, lacks an internal exon but contains a different internal exon, and uses an alternate splice site in another internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK000101, AK300543, DA466245
  3. NR_131767.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) uses an alternate splice site in the 5' terminal exon, lacks an internal exon and uses an alternate splice site in another internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK000101, AK300543, BF983215

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    132996985..133026621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011543503.2XP_011541805.1  zinc finger CCHC domain-containing protein 10 isoform X2

    Conserved Domains (1) summary
    pfam13917
    Location:4988
    zf-CCHC_3; Zinc knuckle
  2. XM_011543502.1XP_011541804.1  zinc finger CCHC domain-containing protein 10 isoform X1

    Conserved Domains (1) summary
    pfam13917
    Location:4988
    zf-CCHC_3; Zinc knuckle
Support Center