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KLHL28 kelch like family member 28 [ Homo sapiens (human) ]

Gene ID: 54813, updated on 15-Jun-2019

Summary

Official Symbol
KLHL28provided by HGNC
Official Full Name
kelch like family member 28provided by HGNC
Primary source
HGNC:HGNC:19741
See related
Ensembl:ENSG00000179454
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BTBD5
Expression
Ubiquitous expression in brain (RPKM 3.6), thyroid (RPKM 3.5) and 25 other tissues See more
Orthologs

Genomic context

See KLHL28 in Genome Data Viewer
Location:
14q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (44924310..44961978, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (45393527..45431179, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101927418 Neighboring gene Ras related GTP binding A pseudogene 1 Neighboring gene chromosome 14 open reading frame 28 Neighboring gene TOG array regulator of axonemal microtubules 1 Neighboring gene uncharacterized LOC105370474

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20081

General protein information

Preferred Names
kelch-like protein 28
Names
BTB (POZ) domain containing 5
BTB/POZ domain-containing protein 5
kelch-like 28

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308112.2NP_001295041.1  kelch-like protein 28 isoform 1

    See identical proteins and their annotated locations for NP_001295041.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK289855, AL049870, BC057794, HY342026
    Consensus CDS
    CCDS76675.1
    UniProtKB/TrEMBL
    A8K1E0, J3KNY7
    Related
    ENSP00000347193.2, ENST00000355081.3
    Conserved Domains (5) summary
    smart00612
    Location:495540
    Kelch; Kelch domain
    PHA03098
    Location:49567
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:437479
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:39142
    BTB; BTB/POZ domain
    pfam07707
    Location:151253
    BACK; BTB And C-terminal Kelch
  2. NM_017658.5NP_060128.2  kelch-like protein 28 isoform 2

    See identical proteins and their annotated locations for NP_060128.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5'-terminal exon, which results in a different 5' UTR and use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AL049870, BC121009, BM998529, DA247273
    Consensus CDS
    CCDS9680.1
    UniProtKB/Swiss-Prot
    Q9NXS3
    Related
    ENSP00000379434.3, ENST00000396128.8
    Conserved Domains (2) summary
    PHA03098
    Location:35553
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:423465
    Kelch; KELCH repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    44924324..44961978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449635.1XP_024305403.1  kelch-like protein 28 isoform X3

    Conserved Domains (2) summary
    sd00038
    Location:321372
    Kelch; KELCH repeat [structural motif]
    cl28614
    Location:35441
    BTB; Broad-Complex, Tramtrack and Bric a brac
  2. XM_011536849.2XP_011535151.1  kelch-like protein 28 isoform X2

    Conserved Domains (6) summary
    smart00612
    Location:402447
    Kelch; Kelch domain
    smart00225
    Location:50146
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00038
    Location:335386
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:39142
    BTB; BTB/POZ domain
    pfam01344
    Location:334387
    Kelch_1; Kelch motif
    pfam07707
    Location:151253
    BACK; BTB And C-terminal Kelch
  3. XM_011536847.3XP_011535149.1  kelch-like protein 28 isoform X1

    See identical proteins and their annotated locations for XP_011535149.1

    UniProtKB/Swiss-Prot
    Q9NXS3
    Conserved Domains (2) summary
    PHA03098
    Location:35553
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:423465
    Kelch; KELCH repeat [structural motif]
  4. XM_005267770.4XP_005267827.1  kelch-like protein 28 isoform X1

    See identical proteins and their annotated locations for XP_005267827.1

    UniProtKB/Swiss-Prot
    Q9NXS3
    Conserved Domains (2) summary
    PHA03098
    Location:35553
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:423465
    Kelch; KELCH repeat [structural motif]
  5. XM_017021378.1XP_016876867.1  kelch-like protein 28 isoform X5

  6. XM_006720174.3XP_006720237.1  kelch-like protein 28 isoform X4

    Conserved Domains (3) summary
    smart00225
    Location:50146
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00651
    Location:39142
    BTB; BTB/POZ domain
    pfam07707
    Location:151253
    BACK; BTB And C-terminal Kelch
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