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PPIC peptidylprolyl isomerase C [ Homo sapiens (human) ]

Gene ID: 5480, updated on 4-Jul-2021

Summary

Official Symbol
PPICprovided by HGNC
Official Full Name
peptidylprolyl isomerase Cprovided by HGNC
Primary source
HGNC:HGNC:9256
See related
Ensembl:ENSG00000168938 MIM:123842
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPC
Summary
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 32.1), placenta (RPKM 29.0) and 24 other tissues See more
Orthologs
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Genomic context

See PPIC in Genome Data Viewer
Location:
5q23.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (123023250..123036725, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (122358945..122372420, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379154 Neighboring gene sorting nexin 2 Neighboring gene sorting nexin 24 Neighboring gene RNA, 7SL, cytoplasmic 689, pseudogene Neighboring gene PPIC antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 711, pseudogene Neighboring gene PRDM6 antisense RNA 1 Neighboring gene PR/SET domain 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3673

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein peptidyl-prolyl isomerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase C
Names
PPIase C
cyclophilin C
parvulin
rotamase C
NP_000934.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000943.5NP_000934.1  peptidyl-prolyl cis-trans isomerase C precursor

    See identical proteins and their annotated locations for NP_000934.1

    Status: REVIEWED

    Source sequence(s)
    AC022116, BG721394, BU075157, BX472017, CB963241
    Consensus CDS
    CCDS4133.1
    UniProtKB/Swiss-Prot
    P45877
    Related
    ENSP00000303057.4, ENST00000306442.5
    Conserved Domains (1) summary
    cl00197
    Location:39197
    cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    123023250..123036725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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