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TRPM4 transient receptor potential cation channel subfamily M member 4 [ Homo sapiens (human) ]

Gene ID: 54795, updated on 23-Apr-2019

Summary

Official Symbol
TRPM4provided by HGNC
Official Full Name
transient receptor potential cation channel subfamily M member 4provided by HGNC
Primary source
HGNC:HGNC:17993
See related
Ensembl:ENSG00000130529 MIM:606936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LTrpC4; PFHB1B; TRPM4B; hTRPM4
Summary
The protein encoded by this gene is a calcium-activated nonselective ion channel that mediates transport of monovalent cations across membranes, thereby depolarizing the membrane. The activity of the encoded protein increases with increasing intracellular calcium concentration, but this channel does not transport calcium. [provided by RefSeq, Mar 2016]
Expression
Broad expression in colon (RPKM 24.0), prostate (RPKM 19.3) and 19 other tissues See more
Orthologs

Genomic context

See TRPM4 in Genome Data Viewer
Location:
19q13.33
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (49157741..49211841)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49661016..49715098)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PTPRF interacting protein alpha 3 Neighboring gene histidine rich calcium binding protein Neighboring gene uncharacterized LOC107985340 Neighboring gene solute carrier family 6 member 21, pseudogene Neighboring gene SUMO1 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • TRP channels, organism-specific biosystem (from REACTOME)
    TRP channels, organism-specific biosystemTransient receptor potential (TRP) channel proteins were first discovered in Drosophila melanogaster and have many homologues in other species including humans. TRPs form cationic channels that can ...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20041

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium activated cation channel activity IDA
Inferred from Direct Assay
more info
PubMed 
calcium activated cation channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium channel activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to ATP IEA
Inferred from Electronic Annotation
more info
 
dendritic cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
inorganic cation transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
membrane depolarization during AV node cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane depolarization during Purkinje myocyte cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane depolarization during bundle of His cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of adipose tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of atrial cardiac muscle cell action potential ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of regulation of vascular smooth muscle cell membrane depolarization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vasoconstriction ISS
Inferred from Sequence or Structural Similarity
more info
 
protein homotetramerization IDA
Inferred from Direct Assay
more info
PubMed 
protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of T cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of heart rate by cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of ventricular cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion import across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
sodium channel complex IDA
Inferred from Direct Assay
more info
PubMed 
spanning component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
spanning component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transient receptor potential cation channel subfamily M member 4
Names
calcium-activated non-selective cation channel 1
long transient receptor potential channel 4
melastatin-4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027551.2 RefSeqGene

    Range
    5001..59083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195227.1NP_001182156.1  transient receptor potential cation channel subfamily M member 4 isoform 2

    See identical proteins and their annotated locations for NP_001182156.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AY297046, BM857470, DA218254
    Consensus CDS
    CCDS56098.1
    UniProtKB/Swiss-Prot
    Q8TD43
    Related
    ENSP00000407492.1, ENST00000427978.6
    Conserved Domains (1) summary
    cl23717
    Location:252307
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
  2. NM_001321281.1NP_001308210.1  transient receptor potential cation channel subfamily M member 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC008891, AK307897, BM857470
    Conserved Domains (1) summary
    cl23717
    Location:137192
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
  3. NM_001321282.1NP_001308211.1  transient receptor potential cation channel subfamily M member 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC008891, BC144122, BM857470
    Conserved Domains (1) summary
    TIGR00870
    Location:315547
    trp; transient-receptor-potential calcium channel protein
  4. NM_001321283.1NP_001308212.1  transient receptor potential cation channel subfamily M member 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC008891, AY297044, BM857470
    UniProtKB/Swiss-Prot
    Q8TD43
    Conserved Domains (1) summary
    cl23717
    Location:78133
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
  5. NM_001321285.1NP_001308214.1  transient receptor potential cation channel subfamily M member 4 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC008891, AK295820, BM857470
    UniProtKB/TrEMBL
    B4DIX5
    Conserved Domains (1) summary
    TIGR00870
    Location:497729
    trp; transient-receptor-potential calcium channel protein
  6. NM_017636.4NP_060106.2  transient receptor potential cation channel subfamily M member 4 isoform 1

    See identical proteins and their annotated locations for NP_060106.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF497623, DA218254
    Consensus CDS
    CCDS33073.1
    UniProtKB/Swiss-Prot
    Q8TD43
    Related
    ENSP00000252826.4, ENST00000252826.10
    Conserved Domains (1) summary
    cl26777
    Location:8511083
    TRP_2; Transient receptor ion channel II

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    49157741..49211841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451557.1XP_024307325.1  transient receptor potential cation channel subfamily M member 4 isoform X2

    Conserved Domains (1) summary
    cl26777
    Location:193425
    TRP_2; Transient receptor ion channel II
  2. XM_005259017.1XP_005259074.1  transient receptor potential cation channel subfamily M member 4 isoform X1

    Conserved Domains (1) summary
    TIGR00870
    Location:422654
    trp; transient-receptor-potential calcium channel protein
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