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PPP1R12C protein phosphatase 1 regulatory subunit 12C [ Homo sapiens (human) ]

Gene ID: 54776, updated on 24-Nov-2020

Summary

Official Symbol
PPP1R12Cprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 12Cprovided by HGNC
Primary source
HGNC:HGNC:14947
See related
Ensembl:ENSG00000125503 MIM:613245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p84; p85; AAVS1; LENG3; MBS85
Summary
The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Expression
Ubiquitous expression in testis (RPKM 32.8), endometrium (RPKM 32.5) and 25 other tissues See more
Orthologs
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Genomic context

See PPP1R12C in Genome Data Viewer
Location:
19q13.42
Exon count:
22
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (55090913..55117637, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (55602281..55628968, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene GP6 antisense RNA 1 Neighboring gene retinol dehydrogenase 13 Neighboring gene EPS8 like 1 Neighboring gene microRNA 7975 Neighboring gene troponin T1, slow skeletal type

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein phosphatase 1, regulatory subunit 12C (PPP1R12C) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434D0412

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 12C
Names
leukocyte receptor cluster (LRC) encoded novel gene 3
leukocyte receptor cluster (LRC) member 3
myosin-binding subunit 85
protein phosphatase 1 myosin-binding subunit of 85 kDa
protein phosphatase 1 myosin-binding subunit p85
protein phosphatase 1, regulatory (inhibitor) subunit 12C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271618.2NP_001258547.1  protein phosphatase 1 regulatory subunit 12C isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site. The encoded isoform (b) is shorter compared to isoform a.
    Source sequence(s)
    AA551617, AB209452, AC010327, AF312028, BC008030, HY013088
    UniProtKB/Swiss-Prot
    Q9BZL4
    Related
    ENSP00000465957.1, ENST00000592993.1
    Conserved Domains (6) summary
    cd00204
    Location:95279
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:105257
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:246300
    Ank_5; Ankyrin repeats (many copies)
    pfam15265
    Location:423621
    FAM196; FAM196 family
    pfam15898
    Location:681779
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:100131
    ANK; ANK repeat [structural motif]
  2. NM_017607.4NP_060077.1  protein phosphatase 1 regulatory subunit 12C isoform a

    See identical proteins and their annotated locations for NP_060077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a)
    Source sequence(s)
    AC010327, AF312028, HY013088
    Consensus CDS
    CCDS12916.1
    UniProtKB/Swiss-Prot
    Q9BZL4
    Related
    ENSP00000263433.1, ENST00000263433.8
    Conserved Domains (6) summary
    cd00204
    Location:95279
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:105257
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:246300
    Ank_5; Ankyrin repeats (many copies)
    pfam15265
    Location:424624
    FAM196; FAM196 family
    pfam15898
    Location:683781
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:100131
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    55090913..55117637 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527045.2XP_011525347.1  protein phosphatase 1 regulatory subunit 12C isoform X2

    Conserved Domains (6) summary
    cd00204
    Location:95279
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:105257
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:246300
    Ank_5; Ankyrin repeats (many copies)
    pfam15265
    Location:423623
    FAM196; FAM196 family
    pfam15898
    Location:682780
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:100131
    ANK; ANK repeat [structural motif]
  2. XM_005259013.4XP_005259070.1  protein phosphatase 1 regulatory subunit 12C isoform X1

    UniProtKB/Swiss-Prot
    Q9BZL4
    Related
    ENSP00000387833.2, ENST00000435544.6
    Conserved Domains (6) summary
    cd00204
    Location:95279
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:105257
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:246300
    Ank_5; Ankyrin repeats (many copies)
    pfam15265
    Location:424622
    FAM196; FAM196 family
    pfam15898
    Location:682780
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    sd00045
    Location:100131
    ANK; ANK repeat [structural motif]
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