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BTG4 BTG anti-proliferation factor 4 [ Homo sapiens (human) ]

Gene ID: 54766, updated on 1-Jun-2020

Summary

Official Symbol
BTG4provided by HGNC
Official Full Name
BTG anti-proliferation factor 4provided by HGNC
Primary source
HGNC:HGNC:13862
See related
Ensembl:ENSG00000137707 MIM:605673
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PC3B; APRO3
Summary
The protein encoded by this gene is a member of the BTG/Tob family. This family has structurally related proteins that appear to have antiproliferative properties. This encoded protein can induce G1 arrest in the cell cycle. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 4.9) See more
Orthologs

Genomic context

See BTG4 in Genome Data Viewer
Location:
11q23.1
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (111383828..111514734, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111338255..111383105, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene POU class 2 homeobox associating factor 1 Neighboring gene RNA, U2 small nuclear 60, pseudogene Neighboring gene uncharacterized LOC100132078 Neighboring gene uncharacterized LOC107984386 Neighboring gene uncharacterized LOC644277 Neighboring gene uncharacterized LOC728196 Neighboring gene microRNA 34b Neighboring gene microRNA 34c Neighboring gene HOATZ cilia and flagella associated protein Neighboring gene layilin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33003

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein BTG4
Names
B-cell translocation gene 4
BTG family member 4
protein PC3b

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367974.1NP_001354903.1  protein BTG4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP002008
  2. NM_001367975.1NP_001354904.1  protein BTG4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP002008
  3. NM_001367976.1NP_001354905.1  protein BTG4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP002008, BC031045
    Related
    ENSP00000432018.1, ENST00000525791.5
  4. NM_017589.4NP_060059.1  protein BTG4 isoform 1

    See identical proteins and their annotated locations for NP_060059.1

    Status: REVIEWED

    Source sequence(s)
    AJ271351, AP002008, BX099301
    Consensus CDS
    CCDS8346.1
    UniProtKB/Swiss-Prot
    Q9NY30
    Related
    ENSP00000348300.2, ENST00000356018.6
    Conserved Domains (1) summary
    pfam07742
    Location:1115
    BTG; BTG family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    111383828..111514734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542876.2XP_011541178.1  protein BTG4 isoform X2

    Conserved Domains (1) summary
    pfam07742
    Location:1115
    BTG; BTG family
  2. XM_024448589.1XP_024304357.1  protein BTG4 isoform X1

    Conserved Domains (1) summary
    pfam07742
    Location:1115
    BTG; BTG family
  3. XM_024448591.1XP_024304359.1  protein BTG4 isoform X1

    Conserved Domains (1) summary
    pfam07742
    Location:1115
    BTG; BTG family
  4. XM_024448592.1XP_024304360.1  protein BTG4 isoform X3

    Conserved Domains (1) summary
    pfam07742
    Location:281
    BTG; BTG family
  5. XM_024448587.1XP_024304355.1  protein BTG4 isoform X1

    Conserved Domains (1) summary
    pfam07742
    Location:1115
    BTG; BTG family
  6. XM_024448588.1XP_024304356.1  protein BTG4 isoform X1

    Conserved Domains (1) summary
    pfam07742
    Location:1115
    BTG; BTG family
  7. XM_024448590.1XP_024304358.1  protein BTG4 isoform X1

    Conserved Domains (1) summary
    pfam07742
    Location:1115
    BTG; BTG family
  8. XM_011542878.3XP_011541180.1  protein BTG4 isoform X4

    Conserved Domains (1) summary
    pfam07742
    Location:1115
    BTG; BTG family
  9. XM_011542880.2XP_011541182.1  protein BTG4 isoform X7

    Conserved Domains (1) summary
    pfam07742
    Location:1115
    BTG; BTG family
  10. XM_011542879.2XP_011541181.1  protein BTG4 isoform X5

    Conserved Domains (1) summary
    pfam07742
    Location:1115
    BTG; BTG family

RNA

  1. XR_947835.2 RNA Sequence

  2. XR_947834.2 RNA Sequence

  3. XR_947848.2 RNA Sequence

  4. XR_947851.2 RNA Sequence

  5. XR_947849.2 RNA Sequence

  6. XR_947852.2 RNA Sequence

  7. XR_002957152.1 RNA Sequence

  8. XR_001747911.2 RNA Sequence

  9. XR_947855.2 RNA Sequence

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