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ZRANB1 zinc finger RANBP2-type containing 1 [ Homo sapiens (human) ]

Gene ID: 54764, updated on 6-Sep-2021

Summary

Official Symbol
ZRANB1provided by HGNC
Official Full Name
zinc finger RANBP2-type containing 1provided by HGNC
Primary source
HGNC:HGNC:18224
See related
Ensembl:ENSG00000019995 MIM:611749
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRABID
Expression
Ubiquitous expression in adrenal (RPKM 10.7), testis (RPKM 10.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZRANB1 in Genome Data Viewer
Location:
10q26.13
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (124939489..124988189)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (126630692..126676758)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene abraxas 2, BRISC complex subunit Neighboring gene uncharacterized LOC107984160 Neighboring gene nucleophosmin 1 pseudogene 31 Neighboring gene C-terminal binding protein 2 Neighboring gene microRNA 4296 Neighboring gene mitochondrial ribosomal protein S21 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp762P2216

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables K63-linked polyubiquitin modification-dependent protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thiol-dependent deubiquitinase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiol-dependent deubiquitinase IDA
Inferred from Direct Assay
more info
PubMed 
enables thiol-dependent deubiquitinase IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K29-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K29-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K33-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K33-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked deubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ubiquitin thioesterase ZRANB1
Names
TRAF-binding domain-containing protein
TRAF-binding protein domain
hTrabid
zinc finger Ran-binding domain-containing protein 1
zinc finger, RAN-binding domain containing 1
NP_060050.2
XP_006717970.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017580.3NP_060050.2  ubiquitin thioesterase ZRANB1

    See identical proteins and their annotated locations for NP_060050.2

    Status: VALIDATED

    Source sequence(s)
    AJ252060, AL731571, AL832925
    Consensus CDS
    CCDS7642.1
    UniProtKB/Swiss-Prot
    Q9UGI0
    Related
    ENSP00000352676.4, ENST00000359653.4
    Conserved Domains (4) summary
    smart00547
    Location:152175
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:88107
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam02338
    Location:438586
    OTU; OTU-like cysteine protease
    pfam18418
    Location:246341
    AnkUBD; Ankyrin ubiquitin-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    124939489..124988189
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717907.2XP_006717970.1  ubiquitin thioesterase ZRANB1 isoform X1

    See identical proteins and their annotated locations for XP_006717970.1

    Conserved Domains (3) summary
    smart00547
    Location:178201
    ZnF_RBZ; Zinc finger domain
    sd00029
    Location:114133
    zf-RanBP2; RanBP2-type Zn finger [structural motif]
    pfam02338
    Location:464612
    OTU; OTU-like cysteine protease
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