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ROPN1 rhophilin associated tail protein 1 [ Homo sapiens (human) ]

Gene ID: 54763, updated on 7-Jun-2020

Summary

Official Symbol
ROPN1provided by HGNC
Official Full Name
rhophilin associated tail protein 1provided by HGNC
Primary source
HGNC:HGNC:17692
See related
Ensembl:ENSG00000065371 MIM:611757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT91; ODF6; ROPN1A; RHPNAP1; ropporin
Summary
The protein encoded by this gene is found in the fibrous sheath of spermatazoa, where it interacts with rhophilin, a Rho GTPase binding protein. The encoded protein also can bind an A-kinase anchoring protein (AKAP110) and a calcium-binding tyrosine phosphorylation-regulated protein (CABYR). This protein may be involved in sperm motility and has been shown to be a cancer-testis antigen in hematologic malignancies. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Expression
Restricted expression toward testis (RPKM 42.1) See more
Orthologs

Genomic context

See ROPN1 in Genome Data Viewer
Location:
3q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (123968521..123992170, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (123687862..123711017, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myosin light chain kinase Neighboring gene Sharpr-MPRA regulatory region 10510 Neighboring gene coiled-coil domain containing 14 Neighboring gene kalirin RhoGEF kinase Neighboring gene microRNA 5002 Neighboring gene ribosomal protein L7 pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434B1222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cilium organization ISS
Inferred from Sequence or Structural Similarity
more info
 
flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to cilium ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
sperm capacitation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sperm capacitation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
motile cilium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
ropporin-1A
Names
cancer/testis antigen 91
outer dense fiber of sperm tails 6
rhophilin-associated protein 1A
ropporin, rhophilin associated protein 1
testis secretory sperm-binding protein Li 239w

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317774.1NP_001304703.1  ropporin-1A isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    BG219480, BG724071, HY055534
    Consensus CDS
    CCDS3026.1
    UniProtKB/Swiss-Prot
    Q9HAT0
    UniProtKB/TrEMBL
    A0A140VKB2
    Related
    ENSP00000385919.3, ENST00000405845.7
    Conserved Domains (1) summary
    cl02594
    Location:1046
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
  2. NM_001317775.1NP_001304704.1  ropporin-1A isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    BG219480, BG722939, HY055534
  3. NM_017578.4NP_060048.2  ropporin-1A isoform a

    See identical proteins and their annotated locations for NP_060048.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC117381, AF303889, BG219480
    Consensus CDS
    CCDS3026.1
    UniProtKB/Swiss-Prot
    Q9HAT0
    UniProtKB/TrEMBL
    A0A140VKB2
    Related
    ENSP00000184183.4, ENST00000184183.8
    Conserved Domains (1) summary
    cl02594
    Location:1046
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains

RNA

  1. NR_133916.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AC117381, BC067767, HY055534
    Related
    ENST00000479867.1
  2. NR_133917.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC111005, HY055534
    Related
    ENST00000459660.5
  3. NR_133918.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AL133624, DB042884, HY055534
  4. NR_133919.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK310283, AL133624, HY055534

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    123968521..123992170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512933.2XP_011511235.1  ropporin-1A isoform X1

    See identical proteins and their annotated locations for XP_011511235.1

    UniProtKB/Swiss-Prot
    Q9HAT0
    UniProtKB/TrEMBL
    A0A140VKB2
    Conserved Domains (1) summary
    cl02594
    Location:1046
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
  2. XM_011512934.2XP_011511236.1  ropporin-1A isoform X1

    See identical proteins and their annotated locations for XP_011511236.1

    UniProtKB/Swiss-Prot
    Q9HAT0
    UniProtKB/TrEMBL
    A0A140VKB2
    Conserved Domains (1) summary
    cl02594
    Location:1046
    DD_R_PKA; Dimerization/Docking domain of the Regulatory subunit of cAMP-dependent protein kinase and similar domains
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