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FEV FEV, ETS transcription factor [ Homo sapiens (human) ]

Gene ID: 54738, updated on 12-Aug-2018

Summary

Official Symbol
FEVprovided by HGNC
Official Full Name
FEV, ETS transcription factorprovided by HGNC
Primary source
HGNC:HGNC:18562
See related
Ensembl:ENSG00000163497 MIM:607150; Vega:OTTHUMG00000133080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PET-1; HSRNAFEV
Summary
This gene belongs to the ETS transcription factor family. ETS family members have a highly conserved 85-amino acid ETS domain that binds purine-rich DNA sequences. The alanine-rich C-terminus of this gene indicates that it may act as a transcription repressor. This gene is exclusively expressed in neurons of the central serotonin (5-HT) system, a system implicated in the pathogeny of such psychiatric diseases as depression, anxiety, and eating disorders. In some types of Ewing tumors, this gene is fused to the Ewing sarcoma (EWS) gene following chromosome translocations. [provided by RefSeq, Jul 2008]
Expression
Biased expression in duodenum (RPKM 1.5), stomach (RPKM 1.5) and 5 other tissues See more
Orthologs

Genomic context

See FEV in Genome Data Viewer
Location:
2q35
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (218981087..218985657, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219845809..219850379, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 5 regulatory subunit 2 Neighboring gene long intergenic non-protein coding RNA 608 Neighboring gene crystallin beta A2 Neighboring gene microRNA 375

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of antibody response to smallpox vaccine.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
neuron fate specification IEA
Inferred from Electronic Annotation
more info
 
neuron maturation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription by RNA polymerase II TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein FEV
Names
FEV (ETS oncogene family)
PC12 ETS domain-containing transcription factor 1
fifth Ewing variant protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023323.1 RefSeqGene

    Range
    5001..9571
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017521.2NP_059991.1  protein FEV

    See identical proteins and their annotated locations for NP_059991.1

    Status: REVIEWED

    Source sequence(s)
    BC023511, Y08976
    Consensus CDS
    CCDS2428.1
    UniProtKB/Swiss-Prot
    Q99581
    Related
    ENSP00000295727.1, OTTHUMP00000164098, ENST00000295727.1, OTTHUMT00000256725
    Conserved Domains (1) summary
    smart00413
    Location:46131
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    218981087..218985657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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