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MPHOSPH8 M-phase phosphoprotein 8 [ Homo sapiens (human) ]

Gene ID: 54737, updated on 17-Jun-2019

Summary

Official Symbol
MPHOSPH8provided by HGNC
Official Full Name
M-phase phosphoprotein 8provided by HGNC
Primary source
HGNC:HGNC:29810
See related
Ensembl:ENSG00000196199 MIM:611626
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TWA3; mpp8; HSMPP8
Expression
Ubiquitous expression in ovary (RPKM 20.0), spleen (RPKM 15.8) and 25 other tissues See more
Orthologs

Genomic context

See MPHOSPH8 in Genome Data Viewer
Location:
13q12.11
Exon count:
16
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (19633648..19673441)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (20207787..20247599)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 Neighboring gene mitochondrial ribosomal protein S31 pseudogene 2 Neighboring gene cancer susceptibility 4 pseudogene 1 Neighboring gene estrogen-related receptor alpha pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 350 Neighboring gene paraspeckle component 1 Neighboring gene RNA, 7SL, cytoplasmic 166, pseudogene Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35237

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
M-phase phosphoprotein 8
Names
M-phase phosphoprotein, mpp
M-phase phosphoprotein, mpp8
two hybrid-associated protein 3 with RanBPM
NP_059990.2
XP_011533426.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017520.4NP_059990.2  M-phase phosphoprotein 8

    See identical proteins and their annotated locations for NP_059990.2

    Status: VALIDATED

    Source sequence(s)
    AL354808, BC003542, DA672302, R60056
    Consensus CDS
    CCDS9287.1
    UniProtKB/Swiss-Prot
    Q99549
    Related
    ENSP00000355388.4, ENST00000361479.10
    Conserved Domains (4) summary
    cd00024
    Location:57109
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00204
    Location:595719
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:606695
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:600631
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    19633648..19673441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535124.3XP_011533426.1  M-phase phosphoprotein 8 isoform X1

    Conserved Domains (4) summary
    cd00024
    Location:57109
    CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
    cd00204
    Location:595719
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:606695
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:600631
    ANK; ANK repeat [structural motif]

RNA

  1. XR_001749586.2 RNA Sequence

  2. XR_001749585.2 RNA Sequence

  3. XR_001749584.2 RNA Sequence

  4. XR_002957453.1 RNA Sequence

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