Format

Send to:

Choose Destination

PPBP pro-platelet basic protein [ Homo sapiens (human) ]

Gene ID: 5473, updated on 10-Oct-2020

Summary

Official Symbol
PPBPprovided by HGNC
Official Full Name
pro-platelet basic proteinprovided by HGNC
Primary source
HGNC:HGNC:9240
See related
Ensembl:ENSG00000163736 MIM:121010
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PBP; TC1; TC2; TGB; LDGF; MDGF; TGB1; B-TG1; CTAP3; CXCL7; NAP-2; SCYB7; THBGB; LA-PF4; THBGB1; Beta-TG; CTAPIII; CTAP-III
Summary
The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]
Expression
Biased expression in bone marrow (RPKM 35.8), spleen (RPKM 5.3) and 2 other tissues See more
Orthologs

Genomic context

See PPBP in Genome Data Viewer
Location:
4q13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (73986439..73988190, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (74852156..74853907, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 1 pseudogene 1 Neighboring gene platelet factor 4 Neighboring gene C-X-C motif chemokine ligand 5 Neighboring gene RNA, 7SL, cytoplasmic 218, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef specifically incorporates CSF2, PPBP (NAP2), CCL5, TNF, FAS, CXCL1, IL12B, MIF and OSM into plasma extracellular vesicles from HIV-1 infected patient samples PubMed
retropepsin gag-pol Connective tissue-activating peptide (CTAPIII) and neutrophil-activating peptide 2 (NAP/2) are generated by digestion of a ubiquitin-CTAPIII conjugate with yeast ubiquitin C-terminal hydrolase (YUH1) and HIV protease, respectively PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
CXCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glucose transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to bacterium IEA
Inferred from Electronic Annotation
more info
 
glucose transmembrane transport TAS
Traceable Author Statement
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
tertiary granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
platelet basic protein
Names
C-X-C motif chemokine 7
CXC chemokine ligand 7
beta-thromboglobulin
chemokine (C-X-C motif) ligand 7
connective tissue-activating peptide III
leukocyte-derived growth factor
low-affinity platelet factor IV
macrophage-derived growth factor
neutrophil-activating peptide 2
small inducible cytokine B7
small inducible cytokine subfamily B, member 7
thrombocidin 1
thrombocidin 2
thromboglobulin, beta-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002704.3NP_002695.1  platelet basic protein preproprotein

    See identical proteins and their annotated locations for NP_002695.1

    Status: REVIEWED

    Source sequence(s)
    AC097709, DA419455
    Consensus CDS
    CCDS3563.1
    UniProtKB/Swiss-Prot
    P02775
    Related
    ENSP00000296028.3, ENST00000296028.4
    Conserved Domains (1) summary
    cd00273
    Location:60122
    Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    73986439..73988190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center