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Parp14 poly (ADP-ribose) polymerase family, member 14 [ Mus musculus (house mouse) ]

Gene ID: 547253, updated on 15-Jul-2024

Summary

Official Symbol
Parp14provided by MGI
Official Full Name
poly (ADP-ribose) polymerase family, member 14provided by MGI
Primary source
MGI:MGI:1919489
See related
Ensembl:ENSMUSG00000034422 AllianceGenome:MGI:1919489
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARTD8; CoaSt6; mKIAA1268; 1600029O10Rik
Summary
Predicted to enable several functions, including NAD+ binding activity; pentosyltransferase activity; and transcription corepressor activity. Involved in negative regulation of interferon-gamma-mediated signaling pathway and positive regulation of interleukin-4-mediated signaling pathway. Located in cytoplasm. Is expressed in Peyer's patch; hemolymphoid system; intestine; and urogenital sinus. Orthologous to human PARP14 (poly(ADP-ribose) polymerase family member 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 6.0), bladder adult (RPKM 4.4) and 21 other tissues See more
Orthologs
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Genomic context

See Parp14 in Genome Data Viewer
Location:
16 B3; 16 25.43 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (35652262..35691904, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (35831892..35871518, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 49 member 4 Neighboring gene predicted gene, 25967 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:35747524-35747731 Neighboring gene Hspb associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_40745 Neighboring gene STARR-positive B cell enhancer mm9_chr16:35817422-35817723 Neighboring gene predicted gene, 26838 Neighboring gene STARR-seq mESC enhancer starr_40746 Neighboring gene STARR-seq mESC enhancer starr_40747 Neighboring gene STARR-seq mESC enhancer starr_40750 Neighboring gene predicted gene, 41467 Neighboring gene 60S ribosomal protein L35a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1268, MGC29390

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD+-protein ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+-protein ADP-ribosyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein mono-ADP-ribosyltransferase PARP14
Names
ADP-ribosyltransferase diphtheria toxin-like 8
PARP-14
collaborator of STAT6
poly [ADP-ribose] polymerase 14
NP_001034619.2
XP_006522455.1
XP_006522457.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039530.3NP_001034619.2  protein mono-ADP-ribosyltransferase PARP14

    See identical proteins and their annotated locations for NP_001034619.2

    Status: VALIDATED

    Source sequence(s)
    AC129574
    Consensus CDS
    CCDS28143.1
    UniProtKB/Swiss-Prot
    E9QP48, Q2EMV9, Q571C6, Q8BN35, Q8VDT6
    UniProtKB/TrEMBL
    B2RSI3
    Related
    ENSMUSP00000037657.9, ENSMUST00000042665.9
    Conserved Domains (8) summary
    COG2110
    Location:812991
    YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]
    cd01439
    Location:16951815
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd02903
    Location:10251167
    Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...
    cd02907
    Location:812987
    Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
    cd12300
    Location:687
    RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cd12543
    Location:226300
    RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    pfam00644
    Location:16441817
    PARP; Poly(ADP-ribose) polymerase catalytic domain
    cl00019
    Location:12401365
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    35652262..35691904 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522392.5XP_006522455.1  protein mono-ADP-ribosyltransferase PARP14 isoform X1

    UniProtKB/TrEMBL
    B2RSI3
    Conserved Domains (5) summary
    smart00506
    Location:12401358
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:17241844
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd12300
    Location:687
    RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cd12543
    Location:226300
    RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cl00019
    Location:812986
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
  2. XM_006522394.5XP_006522457.2  protein mono-ADP-ribosyltransferase PARP14 isoform X2

    UniProtKB/TrEMBL
    B2RSI3
    Conserved Domains (5) summary
    smart00506
    Location:12451363
    A1pp; Appr-1"-p processing enzyme
    cd01439
    Location:17001820
    TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
    cd12300
    Location:692
    RRM1_PAR14; RNA recognition motif 1 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cd12543
    Location:231305
    RRM2_PAR14; RNA recognition motif 2 in vertebrate poly [ADP-ribose] polymerase 14 (PARP-14)
    cl00019
    Location:817991
    Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...