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Cadm1 cell adhesion molecule 1 [ Mus musculus (house mouse) ]

Gene ID: 54725, updated on 23-May-2018
Official Symbol
Cadm1provided by MGI
Official Full Name
cell adhesion molecule 1provided by MGI
Primary source
MGI:MGI:1889272
See related
Ensembl:ENSMUSG00000032076 Vega:OTTMUSG00000024571
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bl2; ST17; Igsf4; Necl2; RA175; Tslc1; Igsf4a; RA175A; RA175B; RA175C; RA175N; SgIGSF; SynCam; AI987920; 2900073G06Rik; 3100001I08Rik
Expression
Broad expression in CNS E18 (RPKM 13.0), CNS E14 (RPKM 8.1) and 15 other tissues See more
Orthologs
See Cadm1 in Genome Data Viewer
Location:
9; 9 A5.3
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (47530170..47862280)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (47338435..47661468)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31756 Neighboring gene predicted gene, 39332 Neighboring gene predicted gene, 31816 Neighboring gene predicted gene 10677 Neighboring gene predicted gene, 32016 Neighboring gene predicted gene, 40518

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell recognition IDA
Inferred from Direct Assay
more info
PubMed 
cell recognition ISO
Inferred from Sequence Orthology
more info
 
detection of stimulus IDA
Inferred from Direct Assay
more info
PubMed 
detection of stimulus ISO
Inferred from Sequence Orthology
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
liver development ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytokine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
susceptibility to natural killer cell mediated cytotoxicity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
susceptibility to natural killer cell mediated cytotoxicity IDA
Inferred from Direct Assay
more info
PubMed 
susceptibility to natural killer cell mediated cytotoxicity ISO
Inferred from Sequence Orthology
more info
 
synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
unidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
axon IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell body fiber IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 
synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
varicosity IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
cell adhesion molecule 1
Names
NECL-2
TSLC-1
cadm1
cell adhesion molecule 1 transcript variant 8abc
immunoglobulin superfamily member 4
immunoglobulin superfamily member 4A
immunosuperfamily protein Bl2
nectin-like 2
nectin-like protein 2
spermatogenic immunoglobulin superfamily
synaptic cell adhesion molecule
tumor suppressor in lung cancer 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025600.1NP_001020771.1  cell adhesion molecule 1 isoform d precursor

    See identical proteins and their annotated locations for NP_001020771.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons compared to variant 1. The resulting isoform (d) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK053839, AY351388, CAAA01092855
    Consensus CDS
    CCDS23147.1
    UniProtKB/Swiss-Prot
    Q8R5M8
    Related
    ENSMUSP00000034581.3, OTTMUSP00000048781, ENSMUST00000034581.3, OTTMUST00000060349
    Conserved Domains (4) summary
    cd05881
    Location:49143
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    cd05883
    Location:164245
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00408
    Location:262323
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:255333
    IG_like; Immunoglobulin like
  2. NM_001310841.1NP_001297770.1  cell adhesion molecule 1 isoform e precursor

    See identical proteins and their annotated locations for NP_001297770.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform e, which is longer than isoform a.
    Source sequence(s)
    AC121870, AC183268, AI848016, AK013911, BB343438, BC094661, JQ782219
    Consensus CDS
    CCDS80990.1
    UniProtKB/TrEMBL
    E9PYN1
    Related
    ENSMUSP00000124119.1, OTTMUSP00000048779, ENSMUST00000152459.7, OTTMUST00000060347
    Conserved Domains (3) summary
    cd05881
    Location:49143
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2
    cd05883
    Location:164245
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00410
    Location:255333
    IG_like; Immunoglobulin like
  3. NM_018770.3NP_061240.3  cell adhesion molecule 1 isoform c precursor

    See identical proteins and their annotated locations for NP_061240.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK053839, BQ043739, CAAA01092855
    Consensus CDS
    CCDS23148.1
    UniProtKB/Swiss-Prot
    Q8R5M8
    Related
    ENSMUSP00000110194.1, OTTMUSP00000048778, ENSMUST00000114547.7, OTTMUST00000060346
    Conserved Domains (4) summary
    cd05881
    Location:49143
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    cd05883
    Location:164245
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00408
    Location:262323
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:255333
    IG_like; Immunoglobulin like
  4. NM_207675.2NP_997558.2  cell adhesion molecule 1 isoform a precursor

    See identical proteins and their annotated locations for NP_997558.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AK013911, AK053839, CAAA01092855
    Consensus CDS
    CCDS23149.1
    UniProtKB/Swiss-Prot
    Q8R5M8
    Related
    ENSMUSP00000083073.2, OTTMUSP00000029433, ENSMUST00000085909.8, OTTMUST00000060345
    Conserved Domains (3) summary
    cd05881
    Location:49143
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2
    cd05883
    Location:164245
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00410
    Location:255333
    IG_like; Immunoglobulin like
  5. NM_207676.2NP_997559.1  cell adhesion molecule 1 isoform b precursor

    See identical proteins and their annotated locations for NP_997559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK053839, BC057125, CAAA01092855
    Consensus CDS
    CCDS23150.1
    UniProtKB/Swiss-Prot
    Q8R5M8
    Related
    ENSMUSP00000110195.1, OTTMUSP00000029432, ENSMUST00000114548.7, OTTMUST00000060344
    Conserved Domains (3) summary
    cd05881
    Location:49143
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2
    cd05883
    Location:164245
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00410
    Location:255333
    IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    47530170..47862280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510497.3XP_006510560.1  cell adhesion molecule 1 isoform X1

    See identical proteins and their annotated locations for XP_006510560.1

    Conserved Domains (3) summary
    cd05881
    Location:49143
    Ig1_Necl-2; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molecule 2
    cd05883
    Location:164245
    Ig2_Necl-2; Second immunoglobulin (Ig)-like domain of nectin-like molecule 2 (also known as cell adhesion molecule 1 (CADM1))
    smart00410
    Location:255333
    IG_like; Immunoglobulin like
  2. XM_017313487.1XP_017168976.1  cell adhesion molecule 1 isoform X2

  3. XM_017313488.1XP_017168977.1  cell adhesion molecule 1 isoform X2

  4. XM_017313489.1XP_017168978.1  cell adhesion molecule 1 isoform X3

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