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Tfip11 tuftelin interacting protein 11 [ Mus musculus (house mouse) ]

Gene ID: 54723, updated on 5-Mar-2024

Summary

Official Symbol
Tfip11provided by MGI
Official Full Name
tuftelin interacting protein 11provided by MGI
Primary source
MGI:MGI:1930075
See related
Ensembl:ENSMUSG00000029345 AllianceGenome:MGI:1930075
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Srr1; TIP33; Tip39; 2810002G02Rik
Summary
Predicted to enable nucleic acid binding activity. Involved in spliceosomal complex disassembly. Located in extracellular matrix. Is expressed in several structures, including alimentary system; central nervous system; ganglia; nose; and retina. Orthologous to human TFIP11 (tuftelin interacting protein 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 25.3), thymus adult (RPKM 19.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
5 F; 5 54.69 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (112474235..112485939)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (112326369..112338073)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6366 Neighboring gene STARR-positive B cell enhancer ABC_E1685 Neighboring gene predicted gene, 46941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:112714594-112714795 Neighboring gene STARR-positive B cell enhancer ABC_E3600 Neighboring gene protein-tyrosine sulfotransferase 2 Neighboring gene SRR1 domain containing Neighboring gene HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 Neighboring gene coiled-coil domain containing 121, retrogene 3 Neighboring gene predicted gene 20636

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within biomineral tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in extracellular matrix organization NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in spliceosomal complex disassembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in spliceosomal complex disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spliceosomal complex disassembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of U2-type post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of U2-type post-mRNA release spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISA
Inferred from Sequence Alignment
more info
PubMed 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISA
Inferred from Sequence Alignment
more info
PubMed 
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tuftelin-interacting protein 11
Names
STIP-1
septin and tuftelin-interacting protein 1
tuftelin-interacting protein 33
tuftelin-interacting protein 39
tuftelin-interacting protein, 39 kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018783.4NP_061253.2  tuftelin-interacting protein 11

    See identical proteins and their annotated locations for NP_061253.2

    Status: PROVISIONAL

    Source sequence(s)
    AC123848
    Consensus CDS
    CCDS19539.1
    UniProtKB/Swiss-Prot
    Q8VD06, Q9ERA6
    UniProtKB/TrEMBL
    Q3TTV6, Q3UGE9
    Related
    ENSMUSP00000031288.8, ENSMUST00000031288.14
    Conserved Domains (3) summary
    pfam01585
    Location:150194
    G-patch; G-patch domain
    pfam07842
    Location:398667
    GCFC; GC-rich sequence DNA-binding factor-like protein
    pfam12457
    Location:21105
    TIP_N; Tuftelin interacting protein N terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    112474235..112485939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)