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Rcan1 regulator of calcineurin 1 [ Mus musculus (house mouse) ]

Gene ID: 54720, updated on 5-Mar-2019

Summary

Official Symbol
Rcan1provided by MGI
Official Full Name
regulator of calcineurin 1provided by MGI
Primary source
MGI:MGI:1890564
See related
Ensembl:ENSMUSG00000022951
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSP1; DSC1; RCN1; Dscr1; MCIP1; CALP1L; Adapt78
Expression
Ubiquitous expression in CNS E18 (RPKM 17.8), heart adult (RPKM 14.9) and 28 other tissues See more
Orthologs

Genomic context

See Rcan1 in Genome Data Viewer
Location:
16 C4; 16 53.6 cM
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (92391951..92466169, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (92392198..92466391, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, Isk-related subfamily, member 1 Neighboring gene predicted gene, 30163 Neighboring gene predicted gene, 29805 Neighboring gene predicted gene, 41498 Neighboring gene predicted gene, 46556 Neighboring gene predicted gene, 46555 Neighboring gene RIKEN cDNA 2410124H12 gene Neighboring gene chloride intracellular channel 6

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
  • Oxytocin signaling pathway, organism-specific biosystem (from KEGG)
    Oxytocin signaling pathway, organism-specific biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Oxytocin signaling pathway, conserved biosystem (from KEGG)
    Oxytocin signaling pathway, conserved biosystemOxytocin (OT) is a nonapeptide synthesized by the magno-cellular neurons located in the supraoptic (SON) and paraventricular (PVN) nuclei of the hypothalamus. It exerts a wide variety of central and ...
  • Thyroid hormone signaling pathway, organism-specific biosystem (from KEGG)
    Thyroid hormone signaling pathway, organism-specific biosystemThe thyroid hormones (THs) are important regulators of growth, development and metabolism. The action of TH is mainly mediated by T3 (3,5,3'-triiodo-L-thyronine). Thyroid hormones, L-thyroxine (T4) a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • 2410048A02Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
calcium-dependent protein serine/threonine phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
calcineurin-NFAT signaling cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
locomotion involved in locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
short-term memory IGI
Inferred from Genetic Interaction
more info
PubMed 
skeletal muscle fiber development IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calcipressin-1
Names
calcineurin inhibitor
down syndrome critical region protein 1 homolog
myocyte-enriched calcineurin-interacting protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081549.2NP_001075018.1  calcipressin-1 isoform 1

    See identical proteins and their annotated locations for NP_001075018.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK146764, BY276032, BY454038
    Consensus CDS
    CCDS37405.1
    UniProtKB/TrEMBL
    Q7TNY3
    Related
    ENSMUSP00000060394.8, ENSMUST00000060005.14
    Conserved Domains (1) summary
    pfam04847
    Location:75244
    Calcipressin; Calcipressin
  2. NM_019466.4NP_062339.2  calcipressin-1 isoform 2

    See identical proteins and their annotated locations for NP_062339.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC162305, AK077283, AK146764, BY454038
    Consensus CDS
    CCDS28337.1
    UniProtKB/Swiss-Prot
    Q9JHG6
    UniProtKB/TrEMBL
    Q542V6, Q7TNY3
    Related
    ENSMUSP00000023672.7, ENSMUST00000023672.9
    Conserved Domains (1) summary
    pfam04847
    Location:22191
    Calcipressin; Calcipressin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    92391951..92466169 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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