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GPN2 GPN-loop GTPase 2 [ Homo sapiens (human) ]

Gene ID: 54707, updated on 4-Feb-2026
Official Symbol
GPN2provided by HGNC
Official Full Name
GPN-loop GTPase 2provided by HGNC
Primary source
HGNC:HGNC:25513
See related
Ensembl:ENSG00000142751 AllianceGenome:HGNC:25513
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPBD1B
Summary
Predicted to enable GTPase activity. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in spleen (RPKM 6.7), duodenum (RPKM 6.2) and 25 other tissues See more
Orthologs
all
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See GPN2 in Genome Data Viewer
Location:
1p36.11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (26876132..26890283, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (26714196..26728346, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (27202623..27216774, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27152961-27153113 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 523 Neighboring gene zDHHC palmitoyltransferase 18 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 525 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27179723-27180224 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27181471-27181643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:27189325-27190204 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 526 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 527 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:27195686-27195844 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:27198339-27199538 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27201365-27201864 Neighboring gene stratifin Neighboring gene GPN2 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:27215935-27216812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 529 Neighboring gene G-patch domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 530 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27232113-27232613 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:27232651-27233152 Neighboring gene nuclear distribution C, dynein complex regulator Neighboring gene nuclear receptor subfamily 0 group B member 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Gpn2 and Rba50 Directly Participate in the Assembly of the Rpb3 Subcomplex in the Biogenesis of RNA Polymerase II. Zeng F, et al. Mol Cell Biol, 2018 Jul 1. PMID 29661922, Free PMC Article
  2. Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis. Liu X, et al. FASEB J, 2020 Nov. PMID 32985767
  3. Affinity Purification Mass Spectrometry on the Orbitrap-Astral Mass Spectrometer Enables High-Throughput Protein-Protein Interaction Mapping. Serrano LR, et al. J Proteome Res, 2025 Apr 4. PMID 40025722, Free PMC Article
  4. Optimized Automated Workflow for BioID Improves Reproducibility and Identification of Protein-Protein Interactions. Cirri E, et al. J Proteome Res, 2024 Oct 4. PMID 39231529, Free PMC Article
  5. CRISPR-based screening identifies XPO7 as a positive regulator of senescence. Li LZ, et al. Protein Cell, 2023 Aug 1. PMID 36897256, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ10349

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
GPN-loop GTPase 2
Names
ATP-binding domain 1 family member B

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018066.4 → NP_060536.3  GPN-loop GTPase 2

    See identical proteins and their annotated locations for NP_060536.3

    Status: VALIDATED

    Source sequence(s)
    AK001211, AL034380, BC007815
    Consensus CDS
    CCDS289.1
    UniProtKB/Swiss-Prot
    Q96HG4, Q9H9Y4, Q9NUE1, Q9NW30
    Related
    ENSP00000363250.3, ENST00000374135.9
    Conserved Domains (2) summary
    COG1100
    Location:13 → 182
    Gem1; GTPase SAR1 family domain [General function prediction only]
    pfam03029
    Location:14 → 261
    ATP_bind_1; Conserved hypothetical ATP binding protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    26876132..26890283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    26714196..26728346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H9Y4.2 GenPept UniProtKB/Swiss-Prot:Q9H9Y4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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