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PPARG peroxisome proliferator activated receptor gamma [ Homo sapiens (human) ]

Gene ID: 5468, updated on 17-Oct-2021

Summary

Official Symbol
PPARGprovided by HGNC
Official Full Name
peroxisome proliferator activated receptor gammaprovided by HGNC
Primary source
HGNC:HGNC:9236
See related
Ensembl:ENSG00000132170 MIM:601487
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARG5; PPARgamma
Summary
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Biased expression in fat (RPKM 44.7), urinary bladder (RPKM 10.3) and 11 other tissues See more
Orthologs
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Genomic context

See PPARG in Genome Data Viewer
Location:
3p25.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (12287368..12434344)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12328867..12475843)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene synapsin II Neighboring gene MT-CO1 pseudogene 5 Neighboring gene glutathione S-transferase mu 5 pseudogene 1 Neighboring gene PPARG eExon liver enhancer Neighboring gene RNA, 5S ribosomal pseudogene 123 Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene RNA, U6 small nuclear 377, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
GeneReviews: Not available
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
GeneReviews: Not available
Carotid intimal medial thickness 1
MedGen: C1836302 OMIM: 609338 GeneReviews: Not available
Compare labs
Familial partial lipodystrophy 3
MedGen: C1720861 OMIM: 604367 GeneReviews: Not available
Compare labs
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
GeneReviews: Not available
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
GeneReviews: Not available
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
GeneReviews: Not available
Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs.
GeneReviews: Not available
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
GeneReviews: Not available
Obesity
MedGen: C0028754 OMIM: 601665 GeneReviews: Not available
Compare labs
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
GeneReviews: Not available
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
GeneReviews: Not available
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
GeneReviews: Not available
Type 2 diabetes mellitus
MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
Compare labs

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates PPARgamma expression in human mesenchymal stem cells PubMed
env In human osteoblast (hOB) cell lines, HIV-1 Gag and gp120 reduce RUNX-2 and PPAR-gamma mRNA expression and activity PubMed
Nef nef HIV-1 Nef suppresses PPAR-gamma expression in human T and macrophage cell lines, and the effects of PPAR-gamma on viral replication is reduced by co-expression of Nef in MT4 T cells PubMed
Pr55(Gag) gag In human osteoblast (hOB) cell lines, HIV-1 Gag and gp120 reduce RUNX-2 and PPAR-gamma mRNA expression and activity PubMed
Tat tat HIV-1 Tat-induced activation of ICAM1 and VCAM1 is inhibited by PPARG likely via AKT signalling in hCMEC/D3 cells PubMed
tat Sera from high viral load HIV-1-infected individuals induce a clear proadipogenic phenotype with increased expression of adipogenic markers including LPL and PPARgamma by HIV-1 Tat-mediated inhibition of COUP TF-1 PubMed
tat HIV-1 Tat enhances the differentiation of mesenchymal stem cells (MSC) toward adipogenesis by the transcription and activity upregulation of PPARgamma PubMed
tat The endogenous PPARgamma ligand 15d-PGJ2 inhibits HIV-1 Tat-induced MCP-1 production in human microglia-like cells PubMed
tat PPARalpha and PPARgamma over-expression prevent Tat-induced binding activity and transactivation of nuclear factor-kappaB PubMed
tat Over-expression of PPARalpha or PPARgamma attenuates Tat-induced up-regulation of inflammatory mediators, such as interleukin (IL)-1beta, tumor necrosis factor-alpha, CCL2, and E-selectin PubMed
Vif vif HIV-1 Vif downregulates the expression of peroxisome proliferator-activated receptor gamma (PPARG) in Vif-expression T cells PubMed
matrix gag HIV-1 MA downregulates PPARG gene expression in HepG2 cells PubMed
gag Treatment of human PBMCs with HIV-1 MA upregulates the expression of MCP-1, ICAM-1, CD40, CD86 and CD36 and downregulates the expression of nuclear receptors FXR and PPARgamma PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA binding domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables LBD domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables R-SMAD binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables STAT family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables alpha-actinin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables arachidonic acid binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables double-stranded DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables prostaglandin receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables protein C-terminus binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
enables retinoid X receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables retinoid X receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription cis-regulatory region binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to insulin stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to low-density lipoprotein particle stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in epithelial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid homeostasis TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in lipoprotein transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in long-chain fatty acid transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in macrophage derived foam cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of SMAD protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cellular response to transforming growth factor beta stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cholesterol storage IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cholesterol storage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of gene silencing by miRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of interferon-gamma-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of macrophage derived foam cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of pathway-restricted SMAD protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of receptor signaling pathway via STAT IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of sequestering of triglyceride IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of negative regulation of smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peroxisome proliferator activated receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in placenta development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of SMAD protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of positive regulation of low-density lipoprotein receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of pathway-restricted SMAD protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of pri-miRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of vascular associated smooth muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cholesterol transporter activity IC
Inferred by Curator
more info
PubMed 
involved_in regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to lipid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to lipid ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in response to nutrient TAS
Traceable Author Statement
more info
PubMed 
involved_in retinoic acid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in white fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in white fat cell differentiation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peroxisome proliferator-activated receptor gamma
Names
PPAR-gamma
nuclear receptor subfamily 1 group C member 3
peroxisome proliferator-activated nuclear receptor gamma variant 1
peroxisome proliferator-activated receptor-gamma 5
peroxisome proliferator-activated receptor-gamma splicing

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011749.1 RefSeqGene

    Range
    5001..151507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330615.4NP_001317544.2  peroxisome proliferator-activated receptor gamma isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and 5' coding region and lacks an alternate exon in the 3' coding region, resulting in a frameshift and different 3' UTR, compared to variant 2. It encodes isoform 3, which is shorter and contains distinct N- and C-termini, compared to isoform 2. Variants 5, 11, and 12 all encode the same isoform (3).
    Source sequence(s)
    AC090947, AC091492, AC093174
    Consensus CDS
    CCDS87046.1
    Related
    ENSP00000380196.2, ENST00000397000.6
    Conserved Domains (3) summary
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
    cl11397
    Location:207243
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  2. NM_001354666.3NP_001341595.2  peroxisome proliferator-activated receptor gamma isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 3, 4, 7, 13, and 14, encodes isoform 1.
    Source sequence(s)
    AC090947, AC091492, AC093174
    Consensus CDS
    CCDS2610.2
    Related
    ENSP00000380205.3, ENST00000397010.7
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  3. NM_001354667.3NP_001341596.2  peroxisome proliferator-activated receptor gamma isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 3, 4, 6, 13, and 14, encodes isoform 1.
    Source sequence(s)
    AC090947, AC091492, AC093174
    Consensus CDS
    CCDS2610.2
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  4. NM_001354668.2NP_001341597.1  peroxisome proliferator-activated receptor gamma isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC090947, AC093174, AJ563369
    Conserved Domains (3) summary
    cd06965
    Location:138221
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:31108
    PPARgamma_N; PPAR gamma N-terminal region
    cl11397
    Location:237274
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  5. NM_001354669.2NP_001341598.1  peroxisome proliferator-activated receptor gamma isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC090947, AC091492, AC093174
    Conserved Domains (1) summary
    cd06932
    Location:34265
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
  6. NM_001354670.2NP_001341599.1  peroxisome proliferator-activated receptor gamma isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC090947, AC091492, AJ563370
    Conserved Domains (3) summary
    cd06965
    Location:110193
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:380
    PPARgamma_N; PPAR gamma N-terminal region
    cl11397
    Location:209246
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  7. NM_001374261.3NP_001361190.2  peroxisome proliferator-activated receptor gamma isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 5 and 12, encodes isoform 3.
    Source sequence(s)
    AC090947, AC091492, AC093174
    Conserved Domains (3) summary
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
    cl11397
    Location:207243
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  8. NM_001374262.3NP_001361191.2  peroxisome proliferator-activated receptor gamma isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 5 and 11, encodes isoform 3.
    Source sequence(s)
    AC090947, AC091492, AC093174
    Conserved Domains (3) summary
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
    cl11397
    Location:207243
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  9. NM_001374263.2NP_001361192.2  peroxisome proliferator-activated receptor gamma isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 1, 3, 4, 6, 7, and 14, encodes isoform 1.
    Source sequence(s)
    AC090947, AC091492, AC093174
    Related
    ENSP00000507893.1, ENST00000683586.1
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  10. NM_001374264.2NP_001361193.2  peroxisome proliferator-activated receptor gamma isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 1, 3, 4, 6, 7, and 13, encodes isoform 1.
    Source sequence(s)
    AC090947, AC091492, AC093174
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  11. NM_001374265.1NP_001361194.1  peroxisome proliferator-activated receptor gamma isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC090947, AC093174
    Related
    ENSP00000507823.1, ENST00000683699.1
    Conserved Domains (3) summary
    cd06965
    Location:138221
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:31108
    PPARgamma_N; PPAR gamma N-terminal region
    cl11397
    Location:237273
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
  12. NM_001374266.1NP_001361195.1  peroxisome proliferator-activated receptor gamma isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC090947, AC091492, AC093174
    Conserved Domains (2) summary
    cd06965
    Location:110193
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:380
    PPARgamma_N; PPAR gamma N-terminal region
  13. NM_005037.7NP_005028.5  peroxisome proliferator-activated receptor gamma isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and 5' coding region compared to variant 2. Variants 1, 3, 4, 6, 7, 13, and 14 all encode the same isoform (1), which has a shorter, distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AC090947, AC091492, AC093174
    Consensus CDS
    CCDS2610.2
    Related
    ENSP00000380210.3, ENST00000397015.7
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  14. NM_015869.5NP_056953.2  peroxisome proliferator-activated receptor gamma isoform 2

    See identical proteins and their annotated locations for NP_056953.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AC090947, AC093174
    Consensus CDS
    CCDS2609.1
    UniProtKB/Swiss-Prot
    P37231
    Related
    ENSP00000287820.6, ENST00000287820.10
    Conserved Domains (3) summary
    cd06932
    Location:237504
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:138221
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:31108
    PPARgamma_N; PPAR gamma N-terminal region
  15. NM_138711.6NP_619725.3  peroxisome proliferator-activated receptor gamma isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region compared to variant 2. Variants 1, 3, 4, 6, 7, 13, and 14 all encode the same isoform (1), which has a shorter, distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AC090947, AC091492, AC093174
    Consensus CDS
    CCDS2610.2
    Related
    ENSP00000498313.1, ENST00000651735.1
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region
  16. NM_138712.5NP_619726.3  peroxisome proliferator-activated receptor gamma isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and 5' coding region compared to variant 2. Variants 1, 3, 4, 6, 7, 13, and 14 all encode the same isoform (1), which has a shorter, distinct N-terminus compared to isoform 2.
    Source sequence(s)
    AC090947, AC091492, AC093174
    Consensus CDS
    CCDS2610.2
    Related
    ENSP00000312472.7, ENST00000309576.11
    Conserved Domains (3) summary
    cd06932
    Location:207474
    NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors
    cd06965
    Location:108191
    NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
    pfam12577
    Location:178
    PPARgamma_N; PPAR gamma N-terminal region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    12287368..12434344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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