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GTPBP2 GTP binding protein 2 [ Homo sapiens (human) ]

Gene ID: 54676, updated on 10-Oct-2020

Summary

Official Symbol
GTPBP2provided by HGNC
Official Full Name
GTP binding protein 2provided by HGNC
Primary source
HGNC:HGNC:4670
See related
Ensembl:ENSG00000172432 MIM:607434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JABELS
Summary
GTP-binding proteins, or G proteins, constitute a superfamily capable of binding GTP or GDP. G proteins are activated by binding GTP and are inactivated by hydrolyzing GTP to GDP. This general mechanism enables G proteins to perform a wide range of biologic activities.[supplied by OMIM, Jan 2003]
Expression
Ubiquitous expression in thyroid (RPKM 18.8), esophagus (RPKM 18.0) and 25 other tissues See more
Orthologs

Genomic context

See GTPBP2 in Genome Data Viewer
Location:
6p21.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (43620492..43631309, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43588218..43596977, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene Yip1 domain family member 3 Neighboring gene RNA polymerase I and III subunit C Neighboring gene exportin 5 Neighboring gene ribosomal protein S2 pseudogene 29 Neighboring gene DNA polymerase eta Neighboring gene MAD2L1 binding protein Neighboring gene radial spoke head component 9 Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene exosome component 8 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC74725

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
nuclear-transcribed mRNA catabolic process, no-go decay IEA
Inferred from Electronic Annotation
more info
 
platelet degranulation TAS
Traceable Author Statement
more info
 
rescue of stalled ribosome IEA
Inferred from Electronic Annotation
more info
 
translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286216.2NP_001273145.1  GTP-binding protein 2 isoform b

    See identical proteins and their annotated locations for NP_001273145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK290267, BC020980
    Consensus CDS
    CCDS69124.1
    UniProtKB/Swiss-Prot
    Q9BX10
    UniProtKB/TrEMBL
    A8K2K2
    Related
    ENSP00000304893.7, ENST00000307114.11
    Conserved Domains (1) summary
    COG5258
    Location:1500
    GTPBP1; GTPase [General function prediction only]
  2. NM_019096.5NP_061969.3  GTP-binding protein 2 isoform a

    See identical proteins and their annotated locations for NP_061969.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL353602, BC064968, CN263880
    Consensus CDS
    CCDS4903.1
    UniProtKB/Swiss-Prot
    Q9BX10
    UniProtKB/TrEMBL
    A0A024RD30
    Related
    ENSP00000303997.5, ENST00000307126.10
    Conserved Domains (1) summary
    COG5258
    Location:59588
    GTPBP1; GTPase [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    43620492..43631309 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446476.1XP_024302244.1  GTP-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cl27768
    Location:7540
    SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]
  2. XM_024446478.1XP_024302246.1  GTP-binding protein 2 isoform X3

    Conserved Domains (1) summary
    COG5258
    Location:1500
    GTPBP1; GTPase [General function prediction only]
  3. XM_024446477.1XP_024302245.1  GTP-binding protein 2 isoform X3

    Conserved Domains (1) summary
    COG5258
    Location:1500
    GTPBP1; GTPase [General function prediction only]
  4. XM_024446475.1XP_024302243.1  GTP-binding protein 2 isoform X1

    Conserved Domains (1) summary
    cl27768
    Location:16540
    SelB; Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]
  5. XM_017010976.1XP_016866465.1  GTP-binding protein 2 isoform X4

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